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Factor H and disease: a complement regulator affects vital body functions   [0032] 
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Methods In Enzymology   [0041] 
Guide To Molecular Cloning Techniques   [0041] 
Molecular Cloning: A Laboratory Manual   [0041] 
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In: Current Protocols in Molecular Biology 15.5   [0041] 
Quantitative Filter Hybridization in Nucleic Acid Hybridization   [0041] 
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Proc. Natl. Acad. Sci. U.S.A.   [0053] 
Mol Immunol   [0104] 
Immunopharmocology   [0104] 
Factor H family proteins: on complement, microbes and human diseases   [0104] 
A radiation hybrid map of complement factor H and factor H-related genes   [0104] 
A novel short consensus repeat-containing molecule is related to human complement factor H   [0104] 
The human factor H-related gene 2 (FHR2): structure and linkage to the coagulation factor XIIIb gene   [0104] 
Complement factor H: sequence analysis of 221 kb of human genomic DNA containing the entire fH, fHR-1 and fHR-3 genes   [0104] 
Biochemical and functional characterization of the factor-H-related protein 4 (FHR-4)   [0104] 
The human factor H-related protein 4 (FHR-4). A novel short consensus repeat-containing protein is associated with human triglyceride-rich lipoproteins   [0104] 
Functional properties of complement factor H-related proteins FHR-3 and FHR-4: binding to the C3d region of C3b and differential regulation by heparin   [0104] 
FHR-4A: a new factor H-related protein is encoded by the human FHR-4 gene   [0104] 
Location and structure of the human FHR-5 gene   [0104] 
Human factor H-related protein 5 has cofactor activity, inhibits C3 convertase activity, binds heparin and C-reactive protein, and associates with lipoprotein   [0104] 
Factor H-related protein-5: a novel component of human glomerular immune deposits   [0104] 
Nat. Biotechnol.   [0107] 
Nat. Biotechnology   [0107] 
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Advances in Nucleic Acid and Protein Analysis   [0107] 
Nuc. Acids Res   [0107] 
Duplex Scorpion primers in SNP analysis and FRET applications   [0107] 
PCR Technology, Principles and Applications for DNA Amplification   [0114] 
Molecular Cloning, A Laboratory Manual   [0117] 
Recombinant DNA Laboratory Manual   [0117] 
Technologies for individual genotyping: detection of genetic polymorphisms in drug targets and disease genes   [0118] 
Detection of single nucleotide polymorphisms   [0118] 
Antibodies: a laboratory manual   [0124] 
Current Protocols in Molecular Biology   [0124] 
Preclinical pharmacokinetics of Ranibizumab (rhuFabV2) after a single intravitreal administration   [0130]  [0172] 
Intravitreal VEGF and bFGF produce florid retinal neovascularization and hemorrhage in the rabbit   [0130] 
Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome   [0139] 
Am J. Hum. Genet.   [0142] 
Localization of the heparin-binding site on complement Factor H   [0143] 
Remington's Pharmaceutical Sciences   [0149] 
Handbook of Pharmaceutical Excipients   [0149] 
Genetic and environmental factors influencing the human factor H plasma levels   [0150] 
Nature Medicine   [0152] 
Development and evaluation of the specificity of a cathepsin D proximal promoter in the eye   [0154] 
Concurrent enhancement of transcriptional activity and specificity of a retinal pigment epithelial cell-preferential promoter   [0154] 
Analysis of the VMD2 promoter and implication of E-box binding factors in its regulation   [0154] 
The Fugu rubripes tyrosinase gene promoter targets transgene expression to pigment cells in the mouse   [0154] 
Adeno-associated viral vectors for retinal gene transfer and treatment of retinal diseases   [0155] 
Gene therapy for optic nerve disease   [0155] 
Prospects for gene therapy   [0155] 
AAV-mediated intravitreal gene therapy reduces lysosomal storage in the retinal pigmented epithelium and improves retinal function in adult MPS VII mice   [0155] 
AAV-Mediated gene transfer slows photoreceptor loss in the RCS rat model of retinitis pigmentosa   [0155] 
Local administration of an adeno-associated viral vector expressing IL-10 reduces monocyte infiltration and subsequent photoreceptor damage during experimental autoimmune uveitis   [0155] 
Efficient gene transfer to retinal pigment epithelium cells with long-term expression   [0155] 
Adenovirus-mediated delivery of catalase to retinal pigment epithelial cells protects neighboring photoreceptors from photo-oxidative stress   [0155] 
An academic centre for gene therapy research and clinical grade manufacturing capability   [0156] 
Adeno-associated virus-vectored gene therapy for retinal disease   [0157] 
Adenovirus-mediated delivery of catalase to retinal pigment epithelial cells protects neighboring photoreceptors from photo-oxidative stress   [0157] 
Gene therapy for Leber congenital amaurosis   [0157] 
Range of retinal diseases potentially treatable by AAV-vectored gene therapy   [0157] 
Nanoparticles for gene delivery to retinal pigment epithelial cells   [0159] 
Long-lasting secretion of transgene product from differentiated and filter-grown retinal pigment epithelial cells after nonviral gene transfer   [0159] 
Targeted gene modification using triplex-forming oligonucleotides   [0160]  [0169] 
Hepatocyte transplantation: clinical and experimental application   [0161]  [0161] 
Large-scale isolation of human hepatocytes for therapeutic application   [0161] 
Attempted treatment of factor H deficiency by liver transplantation   [0161] 
Influence of preservation solution on the isolation and culture of human hepatocytes from liver grafts   [0161] 
In vivo engineering of metabolically active hepatic tissues in a neovascularized subcutaneous cavity   [0161] 
Hepatocyte transplantation for metabolic disorders, experience at King's College hospital and review of literature   [0161] 
Injectable liver: a novel approach using fibrin gel as a matrix for culture and intrahepatic transplantation of hepatocytes   [0161] 
Successful (?) therapy of hemolytic-uremic syndrome with factor H abnormality   [0162] 
Intraocular delivery of oligonucleotides   [0166] 
Setting sights on the treatment of ocular angiogenesis using antisense oligonucleotides   [0166] 
A DNA vector-based RNAi technology to suppress gene expression in mammalian cells   [0167] 
Gene silencing using adenoviral RNAi vector in vascular smooth muscle cells and cardiomyocytes   [0167] 
Hammerhead ribozymes selectively suppress mutant type I collagen mRNA in osteogenesis imperfecta fibroblasts   [0168] 
Hammerhead ribozyme targeting connective tissue growth factor mRNA blocks transforming growth factor-beta mediated cell proliferation   [0168] 
Current Protocols In Molecular Biology   [0181] 
Biologically active recombinant human complement factor H: synthesis and secretion by the baculovirus system   [0183] 
Complement factor H as a marker for detection of bladder cancer   [0183] 
Factor H binds to washed human platelets   [0183] 
Identification of complement regulatory domains in human factor H   [0183] 
Human Factor H-related Protein 5 (FHR-5)   [0183] 
Methods in Enzymology   [0184] 
Protein Purification, Principles and Practice   [0185] 
Guide to Protein Purification   [0185] 
Nature   [0192] 
Nature Biotechnology   [0192] 
Antibodies, A Laboratory Manual   [0192] 
Current Protocols in Immunology   [0192] 
Monoclonal Antibodies, Principles and Practice   [0192] 
A new subtraction technique for molecular cloning of rare antiviral antibody specificities from phage display libraries   [0192] 
Isolation of neutralizing anti-C5a monoclonal antibodies from a filamentous phage monovalent Fab display library   [0192] 
Isolation of monoclonal antibodies recognizing rare and dominant epitopes in plant vascular cell walls by phage display subtraction   [0192] 
Advances in monoclonal antibody technology: genetic engineering of mice, cells, and immunoglobulins   [0196] 
SDR grafting - a new approach to antibody humanization   [0196] 
Proc. Natl: Acad. Sci. USA   [0196] 
Age-related macular degeneration: a high-resolution genome scan for susceptibility loci in a population enriched for late-stage disease   [0266] 
Inflammation and Alzheimer's disease   [0266] 
Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration   [0266] 
Further evidence for an association of ABCR alleles with age-related macular degeneration. The International ABCR Screening Consortium   [0266] 
Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies   [0266] 
A role for local inflammation in the formation of drusen in the aging eye   [0266] 
Characterization of βeta-amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration   [0266] 
Complement regulatory proteins in glomerular diseases   [0266] 
Membranoproliferative glomerulonephritis type II (Dense Deposit Disease): an update   [0266] 
Human factor H deficiency. Mutations in framework cysteine residues and block in H protein secretion and intracellular catabolism   [0266] 
Decay-accelerating factor expression in the rat kidney is restricted to the apical surface of podocytes   [0266] 
The prognostic value of some clinical and histological parameters in membranoproliferative glomerulonephritis   [0266] 
Haploview: analysis and visualization of LD and haplotype maps   [0266] 
Mesangiocapillary glomerulonephritis type 2 (dense deposit disease): Clinical features of progressive disease   [0266] 
An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group   [0266] 
Encapsulated cell-based intraocular delivery of ciliary neurotrophic factor in normal rabbit: dose-dependent effects on ERG and retinal histology   [0266] 
The Effect of Long Term High Dose Heparin Treatment on the Course of Chronic Proliferative Glomerulonephritis   [0266] 
Idiopathic mesangiocapillary glomerulonephritis. Comparison of types I and II in children and adults and long-term prognosis   [0266] 
Science   [0266] 
Complement factor H mutations and gene polymorphisms in haemolytic uraemic syndrome: the C-257T, the A2089G and the G2881T polymorphisms are strongly associated with the disease   [0266] 
Decreased thickness and integrity of the macular elastic layer of Bruch's membrane correspond to the distribution of lesions associated with age-related macular degeneration   [0266] 
Visual impairment caused by retinal abnormalities in mesangiocapillary (membranoprolifeative) glomerulonephritis type II (''dense deposit disease)   [0266] 
Nature   [0266] 
Monocyte activation in patients with age-related macular degeneration: a biomarker of risk for choroidal neovascularization   [0266] 
Drusen proteome analysis: An approach to the etiology of age-related macular degeneration   [0266] 
Risk profiles for ageing macular disease   [0266] 
Nonanticoagulant Protective Effect of Heparin in Chronic Aminonucleoside Nephrosis   [0266] 
Heterozygous and homozygous factor H deficiencies associated with hemolytic uremic syndrome or membranoproliferative glomerulonephritis: report and genetic analysis of 16 cases   [0266] 
Evolution a long terme des glomérulonéphrites membranoproliferative de l'adulte: remissionspontanée durable chez 13 malades avec étude de biopsies rénales itératives dans 5 cas   [0266] 
Fundus changes in (type II) mesangiocapillary glomerulonephritis stimulating drusen: a histopathologiocal report   [0266] 
Fundus changes in mesangiocapillary glomerulonephritis type II: clinical and fluorescein angiographic findings   [0266] 
Complement factor H Polymorphism and age-related macular degeneration   [0266] 
Predisposition to atypical hemolytic uremic syndrome involves the concurrence of different susceptibility alleles in the regulators of complement activation gene cluster in 1q32   [0266] 
Macrophage depletion diminishes lesion size and severity in experimental choroidal neovascularization   [0266] 
Cloning of the 1.4-kb mRNA species of human complement factor H reveals a novel member of the short consensus repeat family related to the carboxy terminal of the classical 150-kDa molecule   [0266] 
Heparin suppresses mesangial cell proliferation and matrix expansion in experimental mesangioproliferative glomerulonephritis   [0266] 
Clin Chem Lab Med   [0266] 
Nucl Acids Res   [0266] 
Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation   [0266] 
Heparin treatment in pregnancy loss: Potential therapeutic benefits beyond anticoagulation   [0266] 
Estrogen receptor genotypes and haplotypes associated with breast cancer risk   [0266] 
Dense deposit disease. A variant of membranoproliferative glomerulonephritis   [0266] 
Glomerular lesions in the transplanted kidney in children   [0266] 
An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration   [0266] 
Common haplotype in the complement regulatory gene, factor H (HF1/CFH), predisposes individuals to age-related macular degeneration   [0266] 
Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cells   [0266] 
Complement factor H variant increases the risk of age-related macular degeneration   [0266] 
Evaluation of the ARMD1 locus on 1q25-31 in patients with age-related maculopathy: genetic variation in laminin genes and in exon 104 of HEMICENTIN-1.   [0266] 
Transgenic animal bioreactors   [0266] 
The complement system as a therapeutic target in autoimmunity   [0266] 
Pathogenesis of lesions in late age-related macular disease   [0266] 
Peripheral drusen in membranoproliferative glomerulonephritis   [0266] 
Model Free Linkage Analysis in Extended Families Confirms a Susceptibility Locus for Age Related Macular Degeneration (ARMD) on 1q31 [ARVO Abstract   [0266] 
In situ complement activation in porcine membranoproliferative glomerulonephritis type II   [0266] 
A potential role for immune complex pathogenesis in drusen formation   [0266] 
Complement activation and inflammatory processes in drusen formation and age-related macular degeneration   [0266] 
The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration   [0266] 
Biology of complement: the overture   [0266] 
Genetic risk of age-related maculopathy. Population-based familial aggregation study   [0266] 
Genetic association of apolipoprotein E with age-related macular degeneration   [0266] 
Age-related macular degeneration. Clinical features in a large family and linkage to chromosome 1q   [0266] 
Complement factor H polymorphism in age-related macular degeneration   [0266] 
Genetics of age-related macular degeneration   [0266] 
Prevalence of age-related maculopathy   [0266] 
The epidemiology of age-related macular degeneration   [0266] 
Subretinal neovascular membranes associated with chronic membranoproliferative glomerulonephritis type II   [0266] 
Transgenic chickens as bioreactors for protein-based drugs   [0266] 
The role of complement in autoimmunity   [0266] 
Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome   [0266] 
Retinal changes associated with type 2 glomerulonephritis   [0266] 
Membranoproliferative glomerulonephritis: The Cincinnati experience cumulative renal survival from 1957 to 1989.   [0266] 
Human factor H-related protein 5 (FHR-5). A new complement-associated protein   [0266] 
Regulation of alternative pathway complement activation by glycosaminoglycans: specificity of the polyanion binding site on factor H   [0266] 
The association of prior cytomegalovirus infection with neovascular age-related macular degeneration   [0266] 
Complement deficiency and disease   [0266] 
Regulation of the complement membrane attack pathway   [0266] 
Characterization of drusen-associated glycoconjugates   [0266] 
Drusen associated with aging and age-related macular degeneration contain molecular constituents common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis and dense deposit disease   [0266] 
Structure and composition of drusen associated with glomerulonephritis: Implications for the role of complement activation in drusen biogenesis   [0266] 
Factor H-related protein-5: a novel component of human glomerular immune deposits   [0266] 
Linkage of a gene causing familial membranoproliferative glomerulonephritis type III to chromosome 1   [0266] 
Adv. Nucl Acid Prot Analysis   [0266] 
Complement activation and atherosclerosis   [0266] 
Science   [0266] 
Electrophysiology of type II mesangiocapillary glomerulonephritis with associated fundus abnormalities   [0266] 
Proc Natl Acad Sci   [0266] 
The nephrotic syndrome   [0266] 
Identification of membrane-bound CR1 (CD35) in human urine: evidence for its release by glomerular podocytes   [0266] 
Immunological and aetiological aspects of macular degeneration   [0266] 
Clustering of Missense Mutations in the C-Terminal Region of Factor H in Atypical Hemolytic Uremic Syndrome   [0266] 
Nat Biotechnol   [0266] 
Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H   [0266] 
Pendred syndrome and DFNB4 - Mutation screening of SLC26A4 by denaturing high-performance liquid chromatography and the identification of seven novel mutations   [0266] 
Fundus changes in mesangiocapillary glomerulonephritis type II: vitreous fluorophotometry   [0266] 
Factor H Mutations in Hemolytic Uremic Syndrome Cluster in Exons 18-20, a Domain Important for Host Cell Recognition   [0266] 
The complete amino acid sequence of human complement factor H   [0266] 
The human complement factor H: functional roles, genetic variations and disease associations   [0266] 
Heparan sulfate proteoglycans in glomerular inflammation   [0266] 
Location, substructure and composition of basal laminar drusen compared with drusen associated with aging and age-related macular degeneration   [0266] 
Nature   [0266] 
Structural and Functional Characterization of Factor H Mutations Associated with Atypical Hemolytic Uremic Syndrome   [0266] 
An Interactive Web Database of Factor H-Associated Hemolytic Uremic Syndrome Mutations: Insights Into the Structural Consequences of Disease-Associated Mutations   [0266] 
Analysis of the ARMD1 locus: evidence that a mutation in HEMICENTIN-1 is associated with age-related macular degeneration in a large family   [0266] 
Complement analysis in children with idiopathic membranoproliferative glomerulonephritis: A long-term follow-up   [0266] 
Association between C-reactive protein and age-related macular degeneration   [0266] 
The epidemiology of age-related macular degeneration   [0266] 
Biologically active recombinant human complement factor H: synthesis and secretion by the baculovirus system   [0266] 
Identification of three physically and functionally distinct binding sites in human complement factor H by deletion mutagenesis   [0266] 
Ying and Yang: complement activation and regulation of Alzheimer's disease   [0266] 
intravitreal implant of encapsulated cell technology (ECT) device in patients with retinitis pigmentosa   [0266] 
The human factor H-related protein 4 (FHR-4). A novel short consensus repeat-containing protein is associated with human triglyceride-rich lipoproteins   [0266] 
Photoreceptor protection by cardiotrophin-1 in transgenic rats with the rhodopsin mutation s334ter   [0266] 
The epsilon4 allele of the apolipoprotein E gene as a potential protective factor for exudative age-related macular degeneration   [0266] 
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences   [0266] 
Therapeutic uses of heparinoids in renal disease patients   [0266] 
Mesangiocapillary glomerulonephritis: A long-term study of 40 cases   [0266] 
Encapsulated Cell-Based Delivery of CNTF Reduces Photoreceptor Degeneration in Animal Models of Retinitis Pigmentosa   [0266] 
Nucleic Acids Res   [0266] 
Differential expression of complement components in human fetal and adult kidneys   [0266] 
Processes in atherogenesis complement activation   [0266] 
Genetic factors in age-related macular degeneration   [0266] 
Regulation of C3 and factor H synthesis of human glomerular mesangial cells by IL-1 and interferon-gamma   [0266] 
Epidemiology of age-related macular degeneration   [0266] 
Epidemiology of age-related maculopathy   [0266] 
The prevalence of age-related maculopathy in the Rotterdam Study   [0266] 
Complement. First of two parts   [0266] 
Systematic identification and analysis of exonic splicing silencers   [0266] 
Age-related maculopathy: a genomewide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regions.   [0266] 
Age-related maculopathy: an expanded genome-wide scan with evidence of susceptibility loci within the 1q31 and 17q25 regions   [0266] 
Control of the amplification convertase of complement by the plasma protein β1H   [0266] 
Age Related Macular Degeneration: a review of pathogenesis   [0266] 
Current concepts in the pathogenesis of age-related macular degeneration   [0266] 
Complement factor H and hemolytic uremic syndrome   [0266] 
Factor H family proteins: on complement, microbes and human diseases   [0266] 
The role of complement in membranoproliferative glomerulonephritis   [0266] 
Complement factor H: physiology and pathophysiology   [0266] 
Hemolytic uremic syndrome: how do factor H mutants mediate endothelial damage   [0266]