Description  Claims  Drawing  Cited references 

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Bioorg. Med. Lett.   [0001] 
Bone   [0001] 
Clinical Pharmacology & Therapeutics   [0004] 
Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate   [0017] 
Peptide aldehyde inhibitors of cathepsin K inhibit bone resorption both in vivo and in vitro   [0017] 
Impaired osteoclast bone resorption leads to osteopetrosis in cathepsin K-deficient mice   [0018] 
Expression of cathepsin K mRNA and protein in odontoclasts after experimental tooth movement in the mouse maxilla by in situ hybridization and immunoelectron microscopy   [0019] 
Pathogenesis of bone erosions in rheumatoid arthritis   [0020] 
Comparison of Cathepsin K and S expression within the Rheumatoid and Osteoarthritic Synovium   [0020]  [0022] 
Osteoclastic activation is the principal mechanism leading to secondary osteoporosis in rheumatoid arthritis   [0020] 
Osteoarthritis and bone: osteologic types of osteoarthritis of the hip   [0021] 
Role of subchondral bone in the initiation and progression of cartilage damage   [0021] 
Expression of Cathepsin K messenger RNA in giant cells and their precursors in human osteoarthritic synovial tissues   [0022] 
Acidic cysteine endoproteinase cathepsin K in the degeneration of the superficial articular hyaline cartilage in osteoarthritis   [0022] 
The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma   [0023] 
Cathepsin K mRNA and protein expression in prostate cancer progression   [0023] 
Expression of cathepsin K in chordoma   [0023] 
Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells   [0024] 
Disruption of the Cathepsin K Gene Reduces Atherosclerosis Progression and Induces Plaque Fibrosis but Accelerates Macrophage Foam Cell Formation   [0024] 
Identification of cathepsin K as a novel marker of adiposity in white adipose tissue   [0025] 
Gene Expression of Proteases and Protease Inhibitors in the Human Ciliary Epithelium and ODM-2 cells   [0026] 
Pivotal role of cathepsin K in lung fibrosis   [0027] 
Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design   [0028] 
Differentiation and function of osteoclasts   [0030] 
Bisphosphonates Inhibit Breast and Prostate Carcinoma Cell Invasion, an Early Event in the Formation of Bone Metastases   [0031] 
Multiple myeloma cells and cells of the human osteoclast lineage share morphological and cell surface markers   [0032] 
New therapeutic agents for the treatment of bone diseases   [0032] 
Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S   [0033] 
Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice   [0033] 
Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema   [0033] 
Deficiency of the cysteine protease cathepsin S impairs microvessel growth   [0033] 
Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice   [0033] 
J. Org. Chem   [0046] 
Selective inhibitors of the osteoclast vacuolar proton ATPase as novel bone antiresorptive agents   [0054] 
Cholesterol Lowering Drugs   [0056] 
PNAS USA   [0059] 
Anabolic actions of parathyroid hormone on bone   [0060] 
New Eng J Med   [0060] 
Parathyroid hormone-related protein-(1-36) stimulates renal tubular calcium reabsorption in normal human volunteers: implications for the pathogenesis of humoral hypercalcemia of malignancy   [0061] 
Vitamin D photobiology, metabolism, and clinical applications   [0063] 
Design of Prodrugs   [0070] 
Stereochemistry of Carbon Compounds   [0081] 
Pharmaceutical Salts   [0082]