Description     Claims     Drawing  

US5360720A   [0119] 

The Protein Kinase Facts Book   [0002] 
FASEB J.   [0002] 
Science   [0002] 
Cell   [0002] 
Cell   [0002] 
EMBO J.   [0002] 
Nat Rev Immunol   [0004] 
Trends Immunol.   [0005] 
DDT   [0008] 
J Allergy Clin Immunol.   [0008] 
Blood   [0008] 
Blood   [0008] 
Immunol. Rev.   [0009] 
Blood   [0009] 
Nat Rev Immunol   [0009] 
Blood   [0009] 
EMBO J.   [0009] 
J. Exp. Med.   [0014] 
J. E. Med.   [0015] 
J. Biol. Chem.   [0016] 
EMBO J.   [0016] 
Proc. Natl. Acad. Sci. USA   [0017] 
Mol. Cell. Biol.   [0017] 
Mol Cell Biol.   [0017] 
Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings (Post-Meeting Edition)   [0018] 
Br. J. Haematol   [0018] 
Blood   [0018] 
Blood   [0019]  [0021] 
Constitutive activation of the protein tyrosine kinase Syk in Chronic Lymphocytic Leukemia B-cells   [0019] 
Blood   [0019]  [0024] 
Br. J. Haematol.   [0020] 
Blood   [0020] 
JEM   [0020]  [0020] 
Cell   [0021] 
Cell   [0021] 
Nat Rev Cancer   [0021] 
Annu Rev Immunol   [0022] 
Mol Cell   [0022] 
Nature   [0022] 
Cell   [0022] 
Cell   [0022] 
Blood   [0022] 
J Immunol   [0022] 
Br J Haematol   [0023] 
Blood   [0023] 
J Exp Med   [0023] 
Blood   [0023] 
J Immunol   [0023] 
J Pharmacol Exp Ther   [0024] 
Hematology Am Soc Hematol Educ Program   [0024] 
Blood   [0024] 
Blood   [0024] 
Blood   [0025] 
Blood   [0025] 
Brit J. Haematology   [0025] 
J. Immunol   [0025] 
Blood   [0025] 
Z Rheumatol   [0026] 
Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis   [0027] 
C-type lectin receptor-induced NF-κB activation in innate immune and inflammatory responses   [0028] 
The role of Syk/CARD9 coupled C-type lectins in antifungal immunity   [0028] 
Mycobacterium abscessus activates the NLRP3 inflammasome via Dectin-1-Syk and p62/SQSTM1   [0028] 
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease   [0030] 
LRRK2 in Parkinson's disease: protein domains and functional insights   [0030] 
LRRK2: a common pathway for parkinsonism, pathogenesis and prevention?   [0030] 
LRRK2 mutations in Parkinson disease   [0030] 
A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations   [0030] 
The LRRK2 G2019S mutation is associated with Parkinson disease and concomitant non-skin cancers   [0030] 
LRRK2 variant associated with Alzheimer's disease   [0030] 
LRRK2 and Human Disease: A Complicated Question or a Question of Complexes?   [0030] 
The role of LRRK2 in inflammatory bowel disease'', Cell research; ''LRRK2 as a negative regulator of NFAT: implications for the pathogenesis of inflammatory bowel disease'' Puja Vora, Dermot PB McGovern   [0031] 
Development of a novel bioavailable inhibitor of the calmodulin-regulated protein kinase MLCK: a lead compound that attenuates vascular leak   [0033] 
unpublished observations; Bratcher J M and Korelitz B I (2006) Toxicity of infliximab in the course of Crohn's disease   [0033] 
A porous defense: the leaky epithelial barrier in intestinal disease   [0033] 
Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo   [0033] 
The burn edema process: current concepts   [0033] 
Ventilator-induced lung injury: lessons from experimental studies   [0033] 
Ethanol-induced activation of myosin light chain kinase leads to dysfunction of tight junctions and blood-brain barrier compromise   [0033] 
Myosin light chain kinase-dependent microvascular hyperpermeability in thermal injury   [0033] 
Myosin light chain kinase inhibitors can block invasion and adhesion of human pancreatic cancer cell lines   [0033] 
Mechanism of TNFalpha modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression   [0033] 
Increased expression of myosin light chain kinase mRNA is related to metastasis in non-small cell lung cancer   [0033] 
Protection against endotoxic shock as a consequence of reduced nitrosative stress in MLCK210-null mice   [0033] 
A role for long chain myosin light chain kinase (MLCK-210) in microvascular hyperpermeability during severe burns   [0033] 
Improvement in hyponatremia during hospitalization for worsening heart failure is associated with improved outcomes: insights from the Acute and Chronic Therapeutic Impact of a Vasopressin Antagonist in Chronic Heart Failure (ACTIV in CHF) trial.   [0033] 
Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase-dependent fashion   [0033] 
Dependence of metastatic cancer cell invasion on MLCK-catalyzed phosphorylation of myosin regulatory light chain   [0033] 
Protein kinase signaling in the modulation of microvascular permeability   [0033] 
Myosin light chain phosphorylation in neutrophil-stimulated coronary microvascular leakage   [0033] 
A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease   [0033] 
Role of myosin light chain kinase in regulation of basal blood pressure and maintenance of salt-induced hypertension   [0033] 
Protecting Groups   [0097] 
Protective Groups in Organic Synthesis   [0097] 
Biochem. Pharmacol.   [0113] 
A Simple Kinetic Method for Rapid Mechanistic Analysis of Reversible Enzyme Inhibitors   [0114] 
Leuk Res.   [0119]