Description  Claims  Drawing  Cited references 

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Hyperosmotic BBB disruption   [0009] 
Chemical barrier modification   [0009] 
PRINCIPLES AND PRACTICE OF NEURO-ONCOLOGY   [0047] 
PRINCIPLES OF NEURO-ONCOLOGY   [0047] 
Proc Nat'l Acad. USA   [0075] 
Nature Biotech.   [0076] 
Advanced Drug Delivery Rev.   [0076] 
Cell   [0080] 
Molec. Ther.   [0080] 
PLoS Biology   [0083] 
Methods in Molecular Biology   [0083] 
Cancer Cell   [0196] 
Cancer Cell   [0196]  [0197]  [0198] 
Cell Cycle   [0199] 
Nature Biotechnology   [0202] 
Convection-enhanced delivery of nanoparticles for the treatment for brain tumors   [0208] 
Primary brain tumours in adults   [0208] 
How to Measure Drug Transport across the Blood-Brain Barrier   [0208] 
Modulation of brain tumor capillaries for enhanced drug delivery selectively to brain tumor   [0208] 
Convection-enhanced delivery of macromolecules in the brain   [0208] 
A family of drug transporters: the multidrug resistance-associated proteins   [0208] 
Design of next-generation protein therapeutics   [0208] 
Characterization of a prokaryotic SMC protein involved in chromosome partitioning   [0208] 
RNAi as a gene therapy approach   [0208] 
Short interfering RNA (siRNA)-mediated RNA interference (RNAi) in human cells   [0208] 
Modelling of the blood-brain barrier in drug discovery and development   [0208] 
Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54   [0208] 
Analysis of recombinant DNA using Escherichia coli minicells   [0208] 
HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer   [0208] 
Molecular expression analysis of restrictive receptor for interleukin 13, a brain tumor-associated cancer/testis antigen   [0208] 
Expression of a restrictive receptor for interleukin 13 is associated with glial transformation   [0208] 
Roles of MinC and MinD in the site-specific septation block mediated by the MinCDE system of Escherichia coli   [0208] 
Upregulation of the low-density lipoprotein receptor at the blood-brain barrier: intercommunications between brain capillary endothelial cells and astrocytes   [0208] 
Inhibition of ABCB1 (MDR1) and ABCB4 (MDR3) expression by small interfering RNA and reversal of paclitaxel resistance in human ovarian cancer cells   [0208] 
Systemic siRNA-mediated gene silencing : A new approach to targeted therapy of cancer   [0208] 
Multidisciplinary management of brain metastases   [0208] 
Epidemiology of metastatic brain tumors   [0208] 
Radiolabeling oligosaccharides after mild periodate oxidation   [0208] 
MicroRNA biogenesis: isolation and characterization of the microprocessor complex   [0208] 
The blood-brain and blood tumor barriers: a review of strategies for increasing drug delivery   [0208] 
Therapeutic efficacy of a herpes simplex virus in combination with radiation or temozolomide for intracranial glioblastoma after convection enhanced delivery   [0208] 
EGFRvIII antibody-conjugated iron oxide nanoparticles for magnetic resonance imaging-guided convection-enhanced delivery and targeted therapy of glioblastoma   [0208] 
Intrathecal clonidine in the treatment of intractable pain: a phase I/II study   [0208] 
Effect of guanidino modification and proline substitution on the in vitro stability and blood-brain barrier permeability of endomorphin II   [0208] 
The blood-brain barrier/neurovascular unit in health and disease   [0208] 
IL-13 receptors and signaling pathways: An evolving web   [0208] 
Spontaneous canine gliomas: overexpression of EGFR, PDGFR alpha and IGFBP2 demonstrated by tissue microarray immunophenotyping   [0208] 
Chromosome partitioning in Escherichia coli: novel mutants producing anucleate cells   [0208] 
Topological regulation of cell division in Escherichia coli involves rapid pole to pole oscillation of the division inhibitor MinC under the control of MinD and MinE   [0208] 
4th., Grossman, A.D. spo0J is required for normal chromosome segregation as well as the initiation of sporulation in Bacillus subtilis   [0208] 
Expression of interleukin-13 receptor α2 in glioblastoma multiforme: Implications for targeted therapies   [0208] 
Cancer statistics, 2009. CA Cancer J. Clin.   [0208] 
The targeted delivery of cancer drugs across the blood-brain barrier: chemical modifications of drugs or drug-nanoparticles   [0208] 
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression   [0208] 
Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model   [0208] 
Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles)   [0208] 
Influence of the type of surfactant on the analgesic effects induced by the peptide dalargin after its delivery across the blood-brain barrier using surfactant-coated nanoparticles   [0208] 
Nanoparticulate systems for brain delivery of drugs   [0208] 
Apolipoprotein-mediated transport of nanoparticle- bound drugs across the blood-brain barrier   [0208] 
Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles   [0208] 
Use of nanoparticles for cerebral cancer   [0208] 
Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means   [0208] 
Active efflux across the blood-brain barrier: role of the solute carrier family   [0208] 
Progression-free survival: an important end point in evaluating therapy for recurrent high-grade gliomas   [0208] 
New strategies to deliver anticancer drugs to brain tumors   [0208] 
Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases   [0208] 
The 2007 WHO classification of tumours of the central nervous system   [0208] 
Bacterially derived 400 nm particles for encapsulation and cancer cell targeting of chemotherapeutics   [0208] 
Bacterially-derived nanocells for tumor-targeted delivery of chemotherapeutics and cell cycle inhibitors   [0208] 
Sequential treatment of drug-resistant tumors with targeted minicells containing siRNA or a cytotoxic drug   [0208] 
Nanomedicine: current status and future prospects   [0208] 
High-flow microinfusion: tissue penetration and pharmacodynamics   [0208] 
Drug transport across the blood-brain barrier and the impact of breast cancer resistance protein (ABCG2)   [0208] 
Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi)   [0208] 
siRNA delivery systems for cancer treatment   [0208] 
Cytoplasmic axial filaments in Escherichia coli cells: possible function in the mechanism of chromosome segregation and cell division   [0208] 
Expression of glioma-associated antigens in pediatric brain stem and non-brain stem gliomas   [0208] 
Key contribution of CPEB4-mediated translational control to cancer progression   [0208] 
Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain   [0208] 
Molecular biology of the blood-brain barrier   [0208] 
Drug targeting to the brain   [0208] 
Blood-brain barrier delivery   [0208] 
Biopharmaceutical drug targeting to the brain   [0208] 
Drug transport in brain via the cerebrospinal fluid   [0208] 
Chemotherapy of brain tumour using doxorubicin bound to surfactant-coated poly(butyl cyanoacrylate) nanoparticles: revisiting the role of surfactants   [0208] 
Characterization of a canine glioma cell line as related to established experimental brain tumor models   [0208] 
MinDE-dependent pole-to-pole oscillation of division inhibitor MinC in Escherichia coli   [0208] 
Phase II trial of murine (131)I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection cavities of patients with newly diagnosed malignant gliomas   [0208] 
Functionalization of liposomes with ApoE-derived peptides at different density affects cellular uptake and drug transport across a blood-brain barrier model   [0208] 
Bacteriophage SPO1-induced macromolecular synthesis in minicells of Bacillus subtilis   [0208] 
The next generation of positron emission tomography radiopharmaceuticals in oncology   [0208] 
Biology of interleukin-10   [0208] 
Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells   [0208] 
P-glycoprotein, a gatekeeper in the blood-brain barrier   [0208] 
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview   [0208] 
Therapeutic siRNAs   [0208] 
PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme   [0208] 
Chemotherapy of glioblastoma in rats using doxorubicin-loaded nanoparticles   [0208] 
Ratio of trastuzumab levels in serum and cerebrospinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood-brain barrier   [0208] 
Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials   [0208] 
Genetic and morphological characterization of an Escherichia coli chromosome segregation mutant   [0208] 
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma   [0208] 
Drug efflux transporters in the CNS   [0208] 
Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes   [0208] 
Local convection enhanced delivery of IL4-Pseudomonas exotoxin (NBI-3001) for treatment of patients with recurrent malignant glioma   [0208] 
The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer   [0208] 
Outcomes and prognostic factors in recurrent glioma patients enrolled onto phase II clinical trials   [0208] 
Epidemiology of primary brain tumors: current concepts and review of the literature   [0208] 
Interleukin-13 receptor α2, EphA2, and Fos-related antigen 1 as molecular denominators of high-grade astrocytomas and specific targets for combinatorial therapy   [0208] 
Angiopep-conjugated poly(-ethylene glycol)-co-poly(epsilon-caprolactone) nanoparticles as dual targeting drug delivery system for brain glioma   [0208] 
Complete reversal of multidrug resistance by stable expression of small interfering RNAs targeting MDR1   [0208] 
Increased expression of integrin alpha3betal in highly brain metastatic subclone of a human non-small cell lung cancer cell line   [0208] 
Albumin nanoparticles targeted with Apo E enter the CNS by transcytosis and are delivered to neurones   [0208] 
Conjugation of brain-derived neurotrophic factor to a blood-brain barrier drug targeting system enables neuroprotection in regional brain ischemia following intravenous injection of the neurotrophin   [0208]