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WO2005094322A2   [0003] 
WO2011128701A2   [0003] 
US5223409A   [0089] 

Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition   [0003] 
Gene Expression Technology: Methods in Enzymology   [0047] 
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The epidemiology of UV induced skin cancer   [0112] 
The dark side of light: the damaging effects of UV rays and the protective efforts of MAP kinase signaling in the epidermis   [0112] 
Molecular mechanisms of UV-induced apoptosis   [0112] 
The basal layer in human squamous tumors harbors more UVA than UVB fingerprint mutations: a role for UVA in human skin carcinogenesis   [0112] 
Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern   [0112] 
Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi   [0112] 
Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors   [0112] 
A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans   [0112] 
Benign nodal nevi frequently harbor the activating V600E BRAF mutation   [0112] 
Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity   [0112] 
PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond   [0112] 
AKT/PKB signaling: navigating downstream   [0112] 
Disease mechanism and biomarkers of oral squamous cell carcinoma   [0112] 
p63 expression profiles in human normal and tumor tissues   [0112] 
Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans   [0112] 
EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer   [0112] 
Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases   [0112] 
Opposing roles for calcineurin and ATF3 in squamous skin cancer   [0112] 
Common benign skin tumors   [0112] 
Role of the nude gene in epithelial terminal differentiation   [0112] 
Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt   [0112] 
Foxn1 promotes keratinocyte differentiation by regulating the activity of protein kinase C   [0112] 
Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes   [0112] 
Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells   [0112] 
Apoptosis in seborrheic keratoses: an open door to a new dermoscopic score   [0112] 
Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo   [0112] 
Inhibitor hijacking of Akt activation   [0112] 
mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling   [0112] 
Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity   [0112] 
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor   [0112] 
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells   [0112] 
Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis   [0112] 
High frequency of FGFR3 mutations in adenoid seborrheic keratoses   [0112] 
Easier tissue macroarray (''microchop'') production   [0112] 
Spectrum of FGFR3 mutations in multiple intraindividual seborrheic keratoses   [0112] 
The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response   [0112] 
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex   [0112] 
Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa   [0112] 
The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2   [0112] 
Fos cooperation with PTEN loss elicits keratoacanthoma not carcinoma, owing to p53/p21 WAF-induced differentiation triggered by GSK3beta inactivation and reduced AKT activity   [0112] 
Reoxygenation after severe hypoxia induces cardiomyocyte hypertrophy in vitro: activation of CREB downstream of GSK3beta   [0112] 
The translational landscape of mTOR signalling steers cancer initiation and metastasis   [0112] 
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2   [0112] 
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest   [0112] 
Identification of a proline-rich Akt substrate as a 14-3-3 binding partner   [0112] 
eIF4E--from translation to transformation   [0112] 
UVA induces lesions resembling seborrheic keratoses in mice with keratinocyte-specific PTEN downregulation   [0112] 
PTEN loss in the continuum of common cancers, rare syndromes and mouse models   [0112] 
Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation   [0112]