Description  Claims  Drawing  Cited references 

US61763444   [0001] 
US61845529   [0001] 
EP2511283A   [0005] 
US4911920A   [0070] 
US5403841A   [0070] 
US5212162A   [0070] 
US4861760A   [0070] 

Journal of Pharmaceutical Science   [0037] 
J. Med Chem.   [0040]  [0083]  [0132] 
J. Med Chem.   [0040]  [0083]  [0132] 
ACC   [0040]  [0083]  [0132] 
ACS Med Chem Lett.   [0040]  [0083] 
Antiviral Res   [0040]  [0132] 
ACC   [0040]  [0083]  [0132] 
AAC   [0040]  [0083]  [0132] 
BMCL   [0040]  [0083]  [0130]  [0132] 
J. Virol.   [0040]  [0083]  [0130]  [0132] 
J. Med. Chem.   [0040]  [0083]  [0130]  [0132]  [0132] 
J. Med. Chem.   [0040]  [0083]  [0132] 
Nature Rev. Drug. Discov.   [0040]  [0083]  [0132] 
Pharmaceutical Dosage Forms   [0054] 
The Art, Science and Technology ofPharmaceutical Compounding   [0054] 
Dosage Calculations   [0054] 
Remington: The Science and Practice of Pharmacy   [0054] 
J. Biomater Sci. Polym. Ed.   [0070] 
Pharm. Res.   [0070] 
J. Pharm. Pharmacol.   [0070] 
J. Microencapsul.   [0070] 
Curr. Opin. Biotechnol.   [0070] 
Am. J. Hosp. Pharm.   [0070] 
Antiviral Res.   [0083] 
ACS Med Chem Lett   [0132] 
J. Med. Chem.   [0132]  [0133] 
IDRUGS   [0132] 
J. Med. Chem.   [0132] 
PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage   [0275] 
PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function   [0275] 
PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria   [0275] 
Mitochondrial fusion is essential for organelle function and cardiac homeostasis   [0275] 
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin   [0275] 
HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte   [0275] 
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila   [0275] 
Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y   [0275] 
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations   [0275] 
Therapeutic potential and mechanism of kinetin as a treatment for the human splicing disease familial dysautonomia   [0275] 
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65   [0275] 
Regulation of autophagy by metabolic and stress signaling pathways in the heart   [0275] 
Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes   [0275] 
Mitotracker probes and mitochondrial membrane potential   [0275] 
Isolated mitochondria infusion mitigates ischemia-reperfusion injury of the liver in rats   [0275] 
Ablation of ALCAT1 mitigates hypertrophic cardiomyopathy through effects on oxidative stress and mitophagy   [0275] 
A molecular gate which controls unnatural ATP analogue recognition by the tyrosine kinase v-Src   [0275] 
The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking   [0275] 
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy   [0275] 
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin   [0275] 
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations   [0275] 
PINK1 Protects against Oxidative Stress by Phosphorylating Mitochondrial Chaperone TRAP1   [0275] 
A zebrafish model of PINK1 deficiency reveals key pathway dysfunction including HIF signaling   [0275] 
Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates   [0275] 
Specific correction of a splice defect in brain by nutritional supplementation   [0275] 
PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson's disease   [0275] 
Mitochondrial PINK1--a novel cardioprotective kinase   [0275] 
Loss of PINK1 Increases the Heart's Vulnerability to Ischemia-Reperfusion Injury   [0275] 
A simple and fast experimental model of myocardial infarction in the mouse   [0275] 
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility   [0275] 
Mechanisms of mitophagy   [0275] 
Mitochondrial disease   [0276] 
PINK1-Phosphorylated Mitofusin-2 Is a Parkin Receptor for Culling Damaged Mitochondria   [0276] 
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin   [0276] 
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility   [0276] 
Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of cardiomyopathies   [0276] 
Harrison's Internal Medicine   [0276] 
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations   [0276] 
PINK1 as a molecular checkpoint in the maintenance of mitochondrial function and integrity   [0276] 
Ubiquitin proteasome system in Parkinson's disease: a keeper or a witness   [0276] 
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations   [0276] 
PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson's disease   [0276] 
Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis   [0276] 
PINK1 Protects against Oxidative Stress by Phosphorylating Mitochondrial Chaperone TRAP1   [0276] 
Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP   [0276] 
Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress   [0276] 
PINK1-linked parkinsonism is associated with Lewy body pathology   [0276] 
Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation   [0276] 
Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)   [0276] 
Chemical Genetic Approach for Kinase-Substrate Mapping by Covalent Capture of Thiophosphopeptides and Analysis by Mass Spectrometry   [0276] 
Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates   [0276] 
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65   [0276] 
Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability   [0276] 
Cytokinin-induced differentiation of human myeloid leukemia HL-60 cells is associated with the formation of nucleotides, but not with incorporation into DNA or RNA   [0276] 
Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes   [0276] 
DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene   [0276] 
LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor   [0276] 
Recent advances in the genetics of Parkinson's disease   [0276] 
Too many roads not taken   [0276] 
Turning a protein kinase on or off from a single allosteric site via disulfide trapping   [0276] 
Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase   [0276] 
Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma   [0276]