Description     Claims     Drawing  

US61799647   [0001] 
US61838178B   [0001] 
US61838148B   [0001]  [0021]  [0068] 
US61921007B   [0001] 
US61799647B   [0021]  [0068] 
US1427335W   [0021]  [0068] 

Nature   [0004] 
Science   [0004] 
Curr Opin Microbiol   [0004] 
Cell   [0004] 
Cell Res   [0004]  [0004] 
Nucleic Acids Res   [0004]  [0004] 
Nat Biotechnol   [0004]  [0004]  [0004]  [0027]  [0028]  [0028]  [0101] 
Elife   [0004]  [0004]  [0036]  [0043] 
Nat Biotechnol   [0004]  [0004]  [0091] 
Science   [0004]  [0004]  [0004]  [0028]  [0101] 
Science   [0004]  [0004]  [0091] 
Nat Biotechnol   [0004]  [0004] 
Genetics   [0004] 
Science   [0004]  [0004]  [0028]  [0036]  [0036]  [0101] 
Nat Biotechnol.   [0026] 
Nat Methods   [0028]  [0029] 
Nat Biotechnol   [0029] 
Nat Biotechnol   [0029] 
Nat Biotechnol   [0029] 
Biochemistry   [0031] 
Science   [0036]  [0043] 
Science   [0036] 
Nat Biotechnol.   [0036] 
PLoS One   [0039] 
Cell   [0039] 
Science   [0043] 
BMC Genomics   [0055] 
Biochemistry   [0055] 
RNA Biology   [0061] 
Nat Methods   [0061]  [0063]  [0065] 
Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems   [0061] 
Science   [0063] 
Proc Natl Acad Sci U S A.   [0063] 
Cell   [0064] 
RNA Biology   [0065] 
Nucl. Acids Res.   [0065] 
J. Mol. Biol.   [0067] 
PNAS USA   [0070] 
Cell Cycle   [0072] 
Biol. Cell   [0074] 
Molecular Cloning, A Laboratory Manual   [0077] 
Gene Transfer and Expression: A Laboratory Manual   [0077] 
Current Protocols in Molecular Biology   [0077] 
Gene   [0077] 
Proc. Natl. Acad. Sci. USA   [0078] 
Gene Ther.   [0078] 
Gene Ther.   [0078] 
Blood   [0078] 
Nat. Biotechnol.   [0078] 
J. Biol. Chem.   [0085] 
Guide to Protein Purification, in Methods in Enzymology   [0085] 
J. Bacteriol.   [0085] 
Methods in Enzymology   [0085] 
Nat Biotech   [0093] 
Mol Cell   [0109] 
Nat Biotech   [0109] 
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system   [0141] 
Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease   [0141] 
Multiplex genome engineering using CRISPR/Cas systems   [0141] 
CRISPR/Cas9 systems targeting beta-globin and CCR5 genes have substantial off-target activity   [0141] 
Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems   [0141] 
Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs   [0141] 
A scalable, fully automated process for construction of sequence-ready human exome targeted capture libraries   [0141] 
Heritable genome editing in C. elegans via a CRISPR-Cas9 system   [0141] 
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells   [0141] 
An unbiased genome-wide analysis of zinc-finger nuclease specificity   [0141] 
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes   [0141] 
Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease   [0141] 
Genetic engineering of human pluripotent cells using TALE nucleases   [0141] 
CRISPR/Cas, the immune system of bacteria and archaea   [0141] 
DNA targeting specificity of RNA-guided Cas9 nucleases   [0141] 
Efficient genome editing in zebrafish using a CRISPR-Cas system   [0141] 
Heritable and Precise Zebrafish Genome Editing Using a CRISPR-Cas System   [0141] 
RNA-guided editing of bacterial genomes using CRISPR-Cas systems   [0141] 
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity   [0141] 
RNA-programmed genome editing in human cells   [0141] 
Heritable gene targeting in the mouse and rat using a CRISPR-Cas system   [0141] 
Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems   [0141] 
CRISPR RNA-guided activation of endogenous human genes   [0141] 
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering   [0141] 
Cas9 as a versatile tool for engineering biology   [0141] 
RNA-guided human genome engineering via Cas9   [0141] 
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity   [0141] 
Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection   [0141] 
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases   [0141] 
RNA-guided gene activation by CRISPR-Cas9-based transcription factors   [0141] 
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression   [0141] 
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity   [0141] 
FLASH assembly of TALENs for high-throughput genome editing   [0141] 
ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool   [0141] 
In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites   [0141] 
Zinc Finger Targeter (ZiFiT): an engineered zinc finger/target site design tool   [0141] 
Generation of gene-modified mice via Cas9/RNA-mediated gene targeting   [0141] 
Thermodynamic parameters to predict stability of RNA/DNA hybrid duplexes   [0141] 
CRISPR-based adaptive immune systems   [0141] 
One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering   [0141] 
RNA-guided genetic silencing systems in bacteria and archaea   [0141] 
Optimization of scarless human stem cell genome editing   [0141]