Description     Claims     Drawing  

US61865468   [0001] 
WO2012122368A   [0003] 
US4911920A   [0071]  [0220] 
US5403841A   [0071]  [0220] 
US5212162A   [0071]  [0220] 
US4861760A   [0071]  [0220] 
WO9605309A   [0230] 
US234478   [0267]  [0275] 
US20100292253A1   [0432] 

Pharmaceutical Salts   [0048] 
Pharmaceutical Dosage Forms   [0055] 
The Art, Science and Technology of Pharmaceutical Compounding   [0055] 
Dosage Calculations   [0055] 
Remington: The Science and Practice of Pharmacy   [0055] 
J. Biomater Sci. Polym. Ed.   [0071] 
Pharm. Res.   [0071] 
J. Pharm. Pharmacol.   [0071] 
J. Microencapsul.   [0071] 
Curr. Opin. Biotechnol.   [0071] 
Am. J. Hosp. Pharm.   [0071] 
THE PHARMACOLOGICAL BASIS OF THERAPEUTICS   [0229] 
Pharmaceutical Sciences   [0230] 
Remington's Pharmaceutical Sciences   [0242] 
Nat. Med.   [0268] 
JNM   [0268] 
Structure and function of cellular deoxyribonucleoside kinases   [0342] 
Structure of human dCK suggests strategies to improve anticancer and antiviral therapy   [0342] 
Requirement for deoxycytidine kinase in T and B lymphocyte development   [0342] 
Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress   [0342] 
A deficiency in nucleoside salvage impairs murine lymphocyte development, homeostasis, and survival   [0342] 
Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage   [0342] 
Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication   [0342] 
Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography   [0342] 
Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules   [0342] 
Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: illuminating the role of main-chain reorganization   [0342] 
Structural basis for substrate promiscuity of dCK   [0342] 
Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery   [0342] 
Rearrangement of Acetylenic Keto Alcohols under Meyer-Schuster Reaction Conditions   [0342] 
Solution-phase parallel synthesis with oligoethylene glycol sorting tags. Preparation of all four stereoisomers of the hydroxybutenolide fragment of murisolin and related acetogenins   [0342] 
Highly enantioselective borane reduction of ketones catalyzed by chiral oxazaborolidines. Mechanism and synthetic implications   [0342] 
Comparison of Simple Potential Functions for Simulating Liquid Water   [0342] 
Development and testing of the OPLS all-atom force field on conformational energetics and properties of organic liquids   [0342] 
Molecular modeling of organic and biomolecular systems using BOSS and MCPRO   [0342] 
Free energies of hydration from a generalized Born model and an ALL-atom force field   [0342] 
PDDG/PM3 and PDDG/MNDO: improved semiempirical methods   [0342] 
Semianalytical Treatment of Solvation for Molecular Mechanics and Dynamics   [0342] 
Nonenantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with L- and D-nucleosides   [0342] 
Guanylate kinases from human erythrocytes, hog brain, and rat liver   [0342] 
MULTI-FORTE, a microcomputer program for modelling and simulation of pharmacokinetic data   [0342] 
a simulation and modeling program for pharmacokinetic and pharmacodynamic data analysis   [0342] 
Acta Crystallogr D Biol Crystallogr   [0342] 
Teplyakov, A. Molecular replacement with MOLREP   [0342] 
REFMAC5 for the refinement of macromolecular crystal structures   [0342] 
Features and development of Coot   [0342] 
a tool for high-throughput crystallography of protein-ligand complexes   [0342] 
Molecular modeling of organic and biomolecular systems using BOSS and MCPRO   [0342] 
Improved semiempirical heats of formation through the use of bond and group equivalents   [0342] 
Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress   [0390] 
Thresholds of replication stress signaling in cancer development and treatment   [0390] 
Chemotherapeutic agents circumvent emergence of dasatinib-resistant BCR-ABL kinase mutations in a precise mouse model of Philadelphia chromosome-positive acute lymphoblastic leukemia   [0390] 
Clinical phase I-II and pharmacokinetic study of high-dose thymidine given by continuous intravenous infusion   [0390] 
Simultaneous analysis of eight nucleoside triphosphates in cell lines by liquid chromatography coupled with tandem mass spectrometry   [0390] 
Activation of deoxycytidine kinase by gamma-irradiation and inactivation by hyperosmotic shock in human lymphocytes   [0390] 
Kinetic properties and inhibition of human T lymphoblast deoxycytidine kinase   [0390] 
Translating cancer research into targeted therapeutics   [0390] 
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers   [0390] 
Hallmarks of cancer: the next generation   [0390] 
DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation   [0390] 
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation   [0390] 
Characterization of a gemcitabine-resistant murine leukemic cell line: reversion of in vitro resistance by a mononucleotide prodrug   [0390] 
Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolism   [0390] 
High-dose thymidine infusions in patients with leukemia and lymphoma   [0390] 
Effect of high-dose thymidine infusions in patients with mycosis fungoides   [0390] 
Principles of cancer therapy: oncogene and non-oncogene addiction   [0390] 
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells   [0390] 
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage   [0390] 
Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography   [0390] 
Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules   [0390] 
Role of thymidine in biochemical modulation: a review   [0390] 
Increased deoxycytidine kinase activity by etoposide in L1210 murine leukemic cells   [0390] 
Molecular imaging of lymphoid organs and immune activation by positron emission tomography with a new [18F]-labeled 2'-deoxycytidine analog   [0390] 
Interactions between deoxyribonucleotide and DNA synthesis   [0390]  [0432] 
Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR   [0390] 
Human biodistribution and radiation dosimetry of novel PET probes targeting the deoxyribonucleoside salvage pathway   [0390] 
Imaging proliferation in vivo with [F-18]FLT and positron emission tomography   [0390] 
Novel PET probes specific for deoxycytidine kinase   [0390] 
Cyclodextrins. Toxicologic pathology   [0390] 
Gaussia luciferase reporter assay for monitoring biological processes in culture and in vivo   [0390] 
Requirement for deoxycytidine kinase in T and B lymphocyte development   [0390] 
Targeting cancer metabolism: a therapeutic window opens   [0390] 
The Metabolism of Tumors in the Body   [0390] 
Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia   [0390] 
Functional compartmentation of dCTP pools. Preferential utilization of salvaged deoxycytidine for DNA repair in human lymphoblasts   [0390] 
Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage   [0390] 
Novel Potent Inhibitors of Deoxycytidine Kinase Identified and Compared by Multiple Assays   [0390] 
Mammalian Deoxyribonucleoside Kinases   [0432] 
Structural Basis for Substrate Promiscuity of dCK   [0432] 
Reaction of Human UMP-CMP Kinase with Natural and Analog Substrates   [0432] 
Novel Role of 3-Phosphoglycerate Kinase, a Glycolytic Enzyme, in the Activation of L-Nucleoside Analogs, a new class of Anticancer and Antiviral Agents   [0432] 
Requirement for Deoxycytidine Kinase in T and B Lymphocyte Development   [0432] 
Nucleoside Salvage Pathway Kinases Regulate Hematopoiesis by Linking Nucleotide Metabolism with Replication Stress   [0432] 
Substrate Specificity and Phosphorylation of Antiviral and Anticancer Nucleoside Analogs by Human Deoxyribonucleoside Kinases and Ribonucleoside Kinases   [0432] 
Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage   [0432] 
5-Fluorocytosine Derivatives as Inhibitors of Deoxycytidine Kinase   [0432] 
Novel Potent Inhibitors of Deoxycytidine Kinase Identified and Compared by Multiple Assays   [0432] 
Irreversible Enzyme Inhibitors: Active-Site-Directed Inhibitors of Deoxycytidine Kinase   [0432] 
Lead Optimization and Structure-based Design of Potent and Bioavailable Deoxycytidine Kinase Inhibitors   [0432] 
Technology Insight: Advances in Molecular Imaging and an Appraisal of PET/CT Scanning   [0432] 
PET/CT Imaging: The Incremental Value of Assessing the Glucose Metabolic Phenotype and the Structure of Cancers in a Single Examination   [0432] 
Molecular Imaging of Cancer with Positron Emission Tomography   [0432] 
Oncological Application of Positron Emission Tomography with Fluorine-18   [0432] 
Positron Emission Tomography in Oncology: A Review   [0432] 
Positron Emission Tomography as an Imaging Biomarker   [0432] 
Present Role and Future Prospects of Positron Emission Tomography in Clinical Oncology   [0432] 
18F-FDG Uptake in Lung, Breast, and Colon Cancers: Molecular Biology Correlates and Disease Characterization   [0432] 
The Role of Molecular Imaging in Drug Discovery and Development   [0432] 
Positron Emission Tomography: Applications in Drug Discovery and Drug Development   [0432] 
Positron Emission Tomography for Use in Microdosing Studies   [0432] 
Noninvasive Prediction of Tumor Responses to Gemcitabine using Positron Emission Tomography   [0432] 
Molecular Imaging of Lymphoid Organs and Immune Activation by Positron Emission Tomography with a new [18F]-labeled 2'-deoxycytidine Analog   [0432] 
Novel PET Probes Specific for Deoxycytidine Kinase   [0432] 
Bioluminescent assays for high-throughput screening   [0432] 
Fluorine in Pharmaceuticals: Looking Beyond Intuition   [0432] 
Metabolsim of Fluorine-containing   [0432] 
Reactions of Some Ortho and Para Halogenated Aromatic Nitriles with Ethylenediamine: Selective Synthesis of Imidazolines   [0432] 
Synthesis of 2-Oxazolone-4-Carboxylates from 3-Nosyloxy- and 3-Bromo-2-ketoesters   [0432] 
Synthesis of Benzyl Bromides with Hexabromoacetone: an Alternative Path to Drug Intermediates   [0432] 
15N5)-Labeled Adenine Derivatives: Synthesis and Studies of Tautomerism by 15N NMR Spectroscopy and Theoretical Calculations   [0432] 
Cloning and Expression of Human Deoxycytidine Kinase cDNA   [0432] 
Nucleotide Specificity of Human Deoxycytidine Kinase   [0432] 
The Monte Carlo Method   [0432] 
High-Temperature Equation of State by a Perturbation Method   [0432] 
Perspective on Free-Energy Perturbation Calculations for Chemical Equilibria   [0432] 
Molecular Modeling of Organic and Biomolecular Systems Using BOSS and MCPRO   [0432] 
Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery   [0432] 
Application of Positron Emission Tomography in Drug Development   [0432] 
Comparison of Simple Potential Functions for Simulating Liquid Water   [0432] 
Development and Testing of the OPLS All-Atom Force Field on Conformational Energetics and Properties of Organic Liquids   [0432]