Description  Claims  Drawing  Cited references 

US61867397   [0001] 
US2008076804W   [0010]  [0041]  [0052] 
US4011322A   [0010]  [0041]  [0052] 
US20120232062A   [0010] 
US2009038248W   [0010] 
US2010107739PCT   [0010] 
US2010107742PCT   [0010] 
WO2002089731PCT   [0010] 
WO2005032329PCT   [0010] 
WO2009039248PCT   [0010] 
WO2010039195A   [0010] 
WO2010107739PCT   [0010] 
WO2010107742PCT   [0010] 
US4911920A   [0037]  [0083] 
US5403841A   [0037]  [0083] 
US5212162A   [0037]  [0083] 
US4861760A   [0037]  [0083] 
WO10107739A   [0041]  [0052] 
WO2009039248A   [0041]  [0052] 
WO9605309A   [0075]  [0099] 

Neuroscience   [0006] 
Pharmaceutical Salts   [0011] 
Pharmaceutical Dosage Forms   [0016] 
The Art, Science and Technology of Pharmaceutical Compounding   [0016] 
Dosage Calculations   [0016] 
Remington: The Science and Practice of Pharmacy   [0016] 
Jasper's Basic Mechanisms of the Epilepsies   [0032] 
J. Biomater Sci. Polym. Ed.   [0037] 
Pharm. Res.   [0037] 
J. Pharm. Pharmacol.   [0037] 
J. Microencapsul.   [0037]  [0088] 
Curr. Opin. Biotechnol.   [0037]  [0088] 
Am. J. Hosp. Pharm.   [0037]  [0088] 
Pharmaceutical Sciences   [0075]  [0099] 
J. Pharmacol. Exp. Ther.   [0078] 
The spectrum of SCN1A-related infantile epileptic encephalopathies   [0100] 
SCN1A mutations and epilepsy   [0100] 
Clinical correlations of mutations in the SCN1A gene: from febrile seizures to severe myoclonic epilepsy in infancy   [0100] 
SCN1A mutations in Dravet syndrome: Impact of interneuron dysfunction on neural networks and cognitive outcome   [0100] 
Nav1.1 channels and epilepsy   [0101] 
Reduced sodium channel Na(v)1.1 levels in BACE1-null mice   [0101] 
Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture   [0101] 
Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy   [0101]  [0101] 
Temperature- and age-dependent seizures in a mouse model of severe myoclonic epilepsy in infancy   [0101] 
Specific deletion of Nav1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome   [0101] 
Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scnla gene mutation   [0101] 
The developing zebrafish (Danio rerio): a vertebrate model for high-throughput screening of chemical libraries   [0102] 
The zebrafish: a powerful platform for in vivo, HTS drug discovery   [0102] 
Zebrafish: an integrative system for neurogenomics and neurosciences   [0102] 
Embryonic and larval expression of zebrafish voltage-gated sodium channel alpha-subunit genes   [0103]  [0104]  [0108] 
Optogenetic localization and genetic perturbation of saccade-generating neurons in zebrafish   [0103]  [0104] 
The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy   [0104] 
Cerebellar gene expression profiles of mouse models for Rett syndrome reveal novel MeCP2 targets   [0105] 
Expression of the somatolactin β gene during zebrafish embryonic development   [0106] 
Cloning, mapping, and developmental expression of a sixth zebrafish Na, K-ATPase alpha1 subunit gene (atplala.5)   [0106] 
Towards an integrated view of HCN channel role in epilepsy   [0107] 
Hippocampal gene expression analysis using the ORESTES methodology shows that homer 1a mRNA is upregulated in the acute period of the pilocarpine epilepsy model   [0107] 
Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis   [0107] 
A large-scale mutagenesis screen to identify seizure-resistant zebrafish   [0108]  [0112]  [0118]  [0120]  [0126] 
Spontaneous seizures and altered gene expression in GABA signaling pathways in a mind bomb mutant zebrafish   [0108]  [0112]  [0129] 
A novel zebrafish model of hyperthermia-induced seizures reveals a role for TRPV4 channels and NMDA-type glutamate receptors   [0108]  [0109]  [0118] 
Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression   [0108]  [0109]  [0112]  [0118]  [0126]  [0126]  [0127] 
Expression and function of KCNQ channels in larval zebrafish   [0108]  [0112]  [0118] 
Distinct modes of induced hyperactivity in zebrafish larvae   [0109] 
Severe myoclonic epilepsy in infancy: Dravet syndrome   [0111] 
Zebrafish offer the potential for a primary screen to identify a wide variety of potential anticonvulsants   [0112]  [0119]  [0120]  [0121]  [0127] 
Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures   [0112]  [0119]  [0120]  [0121] 
Automated measurement of zebrafish larval movement   [0112] 
Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs   [0112]  [0113]  [0119] 
Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models   [0112]  [0113] 
Quantitative assessment of motor function in cerebral palsy: evaluation of zoxazolamine (flexin), a new muscular relaxant agent   [0115] 
The effects of centrally acting muscle relaxants on the intrathecal noradrenaline-induced facilitation of the flexor reflex mediated by group II afferent fibers in rats   [0115] 
Some aspects of the pharmacology of clemizole hydrochloride   [0116] 
Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis   [0116] 
Validation of the zebrafish pentylenetetrazol seizure model: locomotor versus electrographic responses to antiepileptic drugs   [0120]  [0121]  [0127] 
ESPERA study: Applicability of the new ILAE criteria for antiepileptic drug resistance of focal epilepsies in current clinical practice   [0120]  [0122] 
Modern antiepileptic drug development has failed to deliver: Ways out of the current dilemma   [0121] 
Key factors in the discovery and development of new antiepileptic drugs   [0121] 
Efficacy of stiripentol in hyperthermia-induced seizures in a mouse model of Dravet syndrome   [0122] 
Autistic-like behaviour in Scnla+/- mice and rescue by enhanced GABA- mediated neurotransmission   [0123] 
The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats   [0124] 
Seizure-modifying potential of histamine H1 antagonists: a clinical observation   [0124]