Description  Claims  Cited references 

WO2004108139A   [0004]  [0011] 
US2011319611A   [0012] 
WO9948878A   [0013] 

Purification and preliminary characterization of stratum corneum chymotryptic enzyme: a proteinase that may be involved in desquamation   [0002] 
Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme   [0002] 
The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family - genomic characterization, mapping, tissue expression and hormonal regulation   [0002] 
Refined characterization of comeodesmosin proteolysis during terminal differentiation of human epidermis and its relationship to desquamation   [0003] 
Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7   [0003] 
A proteolytic cascade of kallikreins in the stratum corneum   [0003] 
Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity   [0003] 
Formation of active IL-1β from pro-IL-1β catalyzed by stratum corneum chymotryptic enzyme in vitro   [0003] 
Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis   [0005] 
Inhibition of human kallikreins 5 and 7 by the serine protease inhibitor lympho-epithelial Kazal-type inhibitor (LEKTI)   [0005] 
Antileukoprotease inhibits stratum corneum chymotryptic enzyme - Evidence for a regulative function in desquamation   [0005] 
Spink5- deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity   [0006] 
Gene polymorphism in Netherton and common atopic disease   [0006] 
Association between polymorphisms in the SPINK5 gene and atopic dermatitis in the Japanese   [0006] 
Corneodesmosomal cadherins are preferential targets of stratum corneum trypsin- and chymotrypsin-like hyperactivity in Netherton syndrome   [0007] 
Serine protease activity and residual LEKTI expression determine phenotype in Netherton syndrome   [0007] 
Epidermal Overexpression of Stratum Corneum Chymotryptic Enzyme in Mice: A Model for Chronic Itchy Dermatitis   [0007] 
Transgenic mice over-expressing a serine protease in the skin: evidence of interferon gamma-independent MHC Il expression by epidermal keratinocytes   [0007] 
Epidermal hyperproliferation and decreased skin barrier function in mice overexpressing stratum corneum chymotryptic enzyme   [0007] 
Stratum corneum chymotryptic enzyme in psoriasis   [0007] 
A proteolytic cascade of kallikreins in the stratum corneum   [0009] 
Bioorganic & Medicinal Chemistry Letters   [0014]