Description  Claims  Drawing  Cited references 

US20130273051A   [0006] 
WO2012148003A   [0006] 
WO2006063415A   [0007] 

J Cancer Res Clin Oncol   [0003] 
J Cell Sci   [0005] 
Nature   [0032] 
Protein Engineering, Design & Selection   [0032] 
Nature Rev Cancer   [0054] 
Cancer Sci   [0054] 
Semin Cell Dev Biol   [0054] 
Remington's Pharmaceutical Sciences   [0074] 
The ADAMs: signalling scissors in the tumour microenvironment   [0123] 
ADAMs in cancer cell proliferation and progression   [0123] 
Who decides when to cleave an ectodomain?   [0123] 
The ''A Disintegrin And Metalloproteases'' ADAM10 and ADAM17: novel drug targets with therapeutic potential?   [0123] 
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts   [0123] 
Adam Meets Eph: An ADAM Substrate Recognition Module Acts as a Molecular Switch for Ephrin Cleavage In trans   [0123]  [0123] 
Regulated cleavage of a contact-mediated axon repellent   [0123] 
Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands   [0123] 
ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling   [0123] 
The Notch Ligands, Jagged and Delta, Are Sequentially Processed by α-Secretase and Presenilin/γ-Secretase and Release Signaling Fragments   [0123] 
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism   [0123] 
Notch signalling in solid tumours: a little bit of everything but not all the time   [0123] 
Regulation of vascular morphogenesis by Notch signaling   [0123] 
Therapeutic approaches to modulating Notch signaling: Current challenges and future prospects   [0123] 
Notch: Implications of endogenous inhibitors for therapy   [0123] 
Current perspective of TACE inhibitors: A review   [0123] 
The cysteine-rich domain regulates ADAM protease function in vivo   [0123] 
Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10   [0123] 
Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C-shaped scaffold   [0123] 
Structures of two elapid snake venom metalloproteases with distinct activities highlight the disulfide patterns in the D domain of ADAMalysin family proteins   [0123] 
Three-dimensional domain architecture of the ADAM family proteinases   [0123] 
The protein disulfide isomerase family: key players in health and disease   [0123] 
Regulation of mature ADAM17 by redox agents for L-selectin shedding   [0123] 
Thiol isomerases negatively regulate the cellular shedding activity of ADAM17   [0123] 
EGFR signal transactivation in cancer cells   [0123] 
The ADAMs family of metalloproteases: multidomain proteins with multiple functions   [0123] 
Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function   [0123] 
NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer   [0123] 
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells   [0123] 
Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1   [0123] 
Heterogeneity of Jagged1 expression in human and mouse intestinal tumors: implications for targeting Notch signaling   [0123] 
An A13 Repeat within the 3'-Untranslated Region of Epidermal Growth Factor Receptor (EGFR) Is Frequently Mutated in Microsatellite Instability Colon Cancers and Is Associated with Increased EGFR Expression   [0123] 
Notch targets and their regulation   [0123] 
ADAM17 Regulates Epidermal Growth Factor Receptor Expression through the Activation of Notch1 in Non-Small Cell Lung Cancer   [0123] 
The Role of the Vascular Endothelial Growth Factor-Delta-like 4 Ligand/Notch4-Ephrin B2 Cascade in Tumor Vessel Remodeling and Endothelial Cell Functions   [0123] 
Gridlock signalling pathway fashions the first embryonic artery   [0123] 
Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells   [0123] 
STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice   [0123] 
Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice   [0123] 
The ADAM metalloproteinases   [0123] 
Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases   [0123] 
ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site   [0123] 
EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt   [0123] 
ADAMs and protein disulfide isomerase: the key to regulated cell-surface protein ectodomain shedding?   [0123] 
From sulfenylation to sulfhydration: what a thiolate needs to tolerate   [0123] 
Labile disulfide bonds are common at the leucocyte cell surface   [0123] 
Membrane-proximal domain of a disintegrin and metalloprotease-17 represents the putative molecular switch of its shedding activity operated by protein-disulfide isomerase   [0123] 
ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function   [0123] 
Ageing, oxidative stress and cancer: paradigms in parallax   [0123] 
Eph receptors and ephrins in cancer: bidirectional signalling and beyond   [0123] 
PTP1B regulates Eph receptor function and trafficking   [0123] 
Therapeutic targeting of EPH receptors and their ligands   [0123] 
Oxidative Stress, Tumor Microenvironment, and Metabolic Reprogramming: A Diabolic Liaison   [0123] 
ROS Function in Redox Signaling and Oxidative Stress   [0123] 
The cancer stem cell marker aldehyde dehydrogenase is required to maintain a drug-tolerant tumor cell subpopulation   [0123] 
Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition   [0123] 
Mechanisms Governing Metastatic Dormancy and Reactivation   [0123] 
Molecular Mechanisms of Cell Segregation and Boundary Formation in Development and Tumorigenesis   [0123] 
Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function   [0123]