Description  Claims  Drawing  Cited references 

US61951294   [0001] 

Biochemistry   [0082] 
Anti-VEGF treatment in neovascular age-related macular degeneration: a treat-and-extend protocol over 2 years   [0136] 
Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies.   [0137] 
A2E induces IL-Iβ production in retinal pigment epithelial cells via the NLRP3 inflammasome   [0137] 
Regression of atherosclerosis   [0137] 
rAAV2/5 gene-targeting to rods: dose-dependent efficiency and complications associated with different promoters   [0137] 
A survey of host range genes in poxvirus genomes   [0137] 
Aβ-induced senescent retinal pigment epithelial cells create a proinflammatory microenvironment in AMD   [0137] 
Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice   [0137] 
Serum cytokine profile in adalimumab-treated refractory uveitis patients: decreased IL-22 correlates with clinical responses   [0137] 
Diagnosis and Treatment of Uveitis   [0137] 
Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS   [0137] 
Treatment of Leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial   [0137] 
A hapten generated from an oxidation fragment of docosahexaenoic acid is sufficient to initiate age-related macular degeneration   [0137] 
Mechanisms of immune privilege in the anterior segment of the eye: what we learn from corneal transplantation   [0137] 
Safety of recombinant adeno-associated virus type 2-RPE65 vector delivered by ocular subretinal injection   [0137] 
A poxvirus-encoded pyrin domain protein interacts with ASC-1 to inhibit host inflammatory and apoptotic responses to infection   [0137] 
Dynamic regulation of Ero1α and peroxiredoxin 4 localization in the secretory pathway   [0137] 
Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells-implications for age-related macular degeneration (AMD)   [0137] 
Targeting photoreceptors via intravitreal delivery using novel, capsid-mutated AAV vectors   [0137] 
Myxomatosis in Australia and Europe: a model for emerging infectious diseases   [0137] 
TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy   [0137] 
Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal   [0137] 
Cleavage of structural proteins during the assembly of the head of bacteriophage T4   [0137] 
The immunoregulatory properties of oncolytic myxoma virus and their implications in therapeutics   [0137] 
The role of inflammasome in Alzheimer's disease   [0137] 
Inflammatory mediators induced by amyloid-β in the retina and RPE in vivo: implications for inflammasome activation in age-related macular degeneration   [0137] 
Secreted immunomodulatory viral proteins as novel biotherapeutics   [0137] 
Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial   [0137] 
Safety and efficacy of gene transfer for Leber's congenital amaurosis   [0137] 
Immunological homeostasis of the eye   [0137] 
Differential roles of AMPKα1 and AMPKα2 in regulating 4-HNE-induced RPE cell death and permeability   [0137] 
Myxoma virus lacking the pyrin-like protein M013 is sensed in human myeloid cells by both NLRP3 and multiple Toll-like receptors, which independently activate the inflammasome and NF-κB innate response pathways   [0137] 
Co-regulation of NF-κB and inflammasome-mediated inflammatory responses by myxoma virus pyrin domain-containing protein M013   [0137] 
Myxoma virus protein M029 is a dual-function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded host tropism and viral replication   [0137] 
The Ca2+/H+ antiporter TMEM165 expression, localization in the developing, lactating and involuting mammary gland parallels the secretory pathway Ca2+ ATPase (SPCA1)   [0137] 
Innate immune signals in autoimmune and autoinflammatory uveitis   [0137] 
Endotoxin-induced uveitis in rats as a model for human disease   [0137] 
Pathological consequences of long-term mitochondrial oxidative stress in the mouse retinal pigment epithelium   [0137] 
Cytokine gene expression in different strains of mice with endotoxin-induced uveitis (EIU)   [0137] 
A filtrable virus causing a tumor-like condition in rabbits and its relationship to virus myxomatosum   [0137] 
Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration   [0137] 
J. Vis. Exp.   [0137] 
Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity   [0137] 
Intracellular trafficking and secretion of inflammatory cytokines   [0137] 
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88   [0137] 
Three-year follow-up after unilateral subretinal delivery of adeno-associated virus in patients with Leber congenital amaurosis type 2   [0137] 
NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration   [0137] 
Intraocular and serum cytokine profiles in patients with intermediate uveitis   [0137] 
ACE2 and Ang-(1-7) confer protection against development of diabetic retinopathy   [0137] 
Injury-induced upregulation of bFGF and CNTF mRNAS in the rat retina   [0137] 
Current concepts in the pathogenesis of age-related macular degeneration   [0137] 
Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors   [0137]