Description  Claims  Drawing  Cited references 

US20030181439A1   [0121] 
US7232814B2   [0121] 
WO2006117212A2   [0121] 
WO2009010298A2   [0121] 
US20060030837A   [0540] 
US7206639B   [0540] 
US20070093878A   [0541] 

Hear. Res.   [0001]  [0002]  [0006] 
Expert Opin. Drug Discov.   [0002] 
Anat. Rec. (Hoboken)   [0002] 
PLoS One   [0002] 
Otolaryngol Head Neck Surg   [0003] 
Am. J. Med. Sci.   [0003] 
Trans. R. Soc. Trop. Med. Hyg.   [0003] 
Trop. Med. Int. Health   [0003] 
Ann. Otol. Rhinol. Laryngol.   [0003] 
Am. J. Gastroenterol.   [0003] 
Otolaryngology   [0006] 
Nat. Rev. Drug Discov.   [0006]  [0579] 
Expert Opin. Emerg. Drugs   [0006]  [0557] 
Sound Pharmaceuticals Inc. successfully completes its first Phase 2 clinical trial with SPI-1005   [0006] 
Drug Discov. Today   [0006] 
Merck Index   [0042] 
Physicians' Desk Reference   [0042] 
The Pharmacological Basis of Therapeutics   [0042] 
The Merck Index   [0047] 
Acta Otolaryngol   [0048] 
Aromaticity   [0063] 
Protective Groups in Organic Synthesis   [0097] 
Crystal Engineering of the Composition of Pharmaceutical Phases. Do Pharmaceutical Co-crystals Represent a New Path to Improved Medicines?   [0107] 
Reagents for Organic Synthesis   [0112] 
Chemistry of Carbon Compounds   [0112] 
Organic Reactions   [0112] 
Advanced Organic Chemistry   [0112] 
Comprehensive Organic Transformations   [0112] 
Indian J. of Biochem. & Biophysics   [0120]  [0121] 
Eur. J. Biochem.   [0120]  [0121] 
ChemBioChem   [0121] 
Cancer Res.   [0121] 
Dissertation   [0121] 
Remington's Pharmaceutical Sciences   [0423] 
Remington's Pharmaceutical Sciences   [0535] 
Goodman & Gilman's The Pharmacological Basis of Therapeutics   [0535] 
Drug Discovery Today   [0539] 
Neuroreport   [0548]  [0554]  [0578] 
Neuroscience   [0548]  [0548]  [0557]  [0578] 
Adiol. Neurootol.   [0549]  [0551] 
J. Neurosci.   [0549] 
Development of cell-based high throughput chemical screens for protection against cisplatin-induced ototoxicity   [0550] 
Auditory and Vestibular Research, Methods and Protocols   [0554] 
Neuroscience   [0554]  [0578] 
Curr. Protoc. Neurosci.   [0557] 
Hear. Res.   [0561]  [0565] 
Apoptosis   [0561] 
Hear. Res.   [0561]  [0561]  [0562]  [0565] 
Hear. Res.   [0564] 
Drug Discov. Today   [0565] 
Cancer cell   [0575] 
Curr. Protoc. Neurosci.   [0576] 
Otol. Neurotol.   [0579] 
Ear Nose Throat J.   [0579] 
Ear Hear.   [0579] 
Otolaryngol. Clin. North Am.   [0579] 
Curr. Opin. Otolaryngol. Head Neck Surg.   [0579] 
Neuron   [0579] 
Adv. Drug Deliv. Rev.   [0579] 
Laryngoscope   [0579] 
Hear Res.   [0581] 
J. Neurosci.   [0581]  [0581] 
J. Neurophysiol.   [0581]  [0581] 
Hearing Research   [0581] 
J. Assoc. Res. Otolaryngol.   [0581] 
Free Radic. Biol. Med.   [0582]  [0582]  [0582] 
J. Acoust. Soc. Am.   [0582] 
Hear. Res.   [0582]  [0582] 
Acta Otolaryngol.   [0582]  [0582] 
Ann. Otol. Rhinol. Laryngol.   [0582] 
Hear. Res.   [0582]  [0582] 
J. Acoust. Soc. Am.   [0582] 
PLoS One   [0583]  [0585] 
Neuron   [0585] 
Mol. Cell Biol.   [0585] 
Nature   [0585] 
Brain Res. Mol. Brain Res.   [0585] 
PLoS One   [0585] 
Long-term administration of magnesium after acoustic trauma caused by gunshot noise in guinea pigs   [0588] 
Intracochlear perfusion of leupeptin and z- VAD-FMK: influence of antiapoptotic agents on gunshot-induced hearing loss   [0588] 
Anti-apoptotic factor z-Val-Ala-Asp-fluoromethylketone promotes the survival of cochlear hair cells in a mouse model for human deafness   [0588] 
Oral magnesium intake reduces permanent hearing loss induced by noise exposure   [0588] 
Intratympanic corticosteroids for sudden idiopathic sensorineural hearing loss   [0588] 
State-of-the-art mechanisms of intracochlear drug delivery   [0588] 
D-methionine (D-met) significantly rescues noise-induced hearing loss: timing studies   [0588] 
Prevention of noise- and drug-induced hearing loss with D-methionine   [0588] 
A new oral otoprotective agent. Part 1: Electrophysiology data from protection against noise-induced hearing loss   [0588] 
Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea   [0588] 
Protection from noise-induced temporary threshold shift by D-methionine is associated with preservation of ATPase activities   [0588] 
Effectiveness of 4-hydroxy phenyl N-tert-butylnitrone (4-OHPBN) alone and in combination with other antioxidant drugs in the treatment of acute acoustic trauma in chinchilla   [0588] 
Profiling drug-induced cell death pathways in the zebrafish lateral line   [0588] 
Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification   [0588] 
Intratympanic steroid perfusion for the treatment of Meniere's disease: a retrospective study   [0588] 
Transfection of mouse cochlear explants by electroporation   [0588] 
Effects of antioxidant treatment on blast-induced brain injury   [0588] 
Antioxidant treatment reduces blast- induced cochlear damage and hearing loss   [0588] 
Outer hair cell-specific prestin- CreERT2 knockin mouse lines   [0588] 
Protection and repair of inner ear sensory cells   [0588] 
Orphan glutamate receptor delta1 subunit required for high- frequency hearing   [0588] 
Mdm2 is required for inhibition of Cdk2 activity by p21, thereby contributing to p53-dependent cell cycle arrest   [0588] 
The effect of impulse intensity and the number of impulses on hearing and cochlear pathology in the chinchilla   [0588] 
The effect of 'conditioning' exposures on hearing loss from impulse noise   [0588] 
CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage   [0588] 
Increased noise trauma in guinea pigs through magnesium deficiency   [0588] 
Dependence of noise-induced hearing loss upon perilymph magnesium concentration   [0588] 
Oral magnesium supplementation as prophylaxis for noise-induced hearing loss: results of a double blind field study   [0588] 
A cochlear cell line as an in vitro system for drug ototoxicity screening   [0588] 
Identification of 17 hearing impaired mouse strains in the TMGC ENU-mutagenesis screen   [0588] 
Roles of NADPH oxidases in cisplatin-induced reactive oxygen species generation and ototoxicity   [0588] 
Activation of beta-catenin by inhibitors of glycogen synthase kinase-3 ameliorates cisplatin-induced cytotoxicity and pro-inflammatory cytokine expression in HEI-OC1 cells   [0588] 
Prevention of impulse noise-induced hearing loss with antioxidants   [0588] 
NAC for noise: from the bench top to the clinic   [0588] 
Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury   [0588] 
Nutrient plasma levels achieved during treatment that reduces noise-induced hearing loss   [0588] 
Nutrient-enhanced diet reduces noise-induced damage to the inner ear and hearing loss   [0588] 
Free radical scavenger vitamins A, C, and E plus magnesium reduce noise trauma   [0588] 
Mechanisms of noise- induced hearing loss indicate multiple methods of prevention   [0588] 
Leflunomide in the treatment of rheumatoid arthritis   [0588] 
Structure-activity relationship study of oxindole- based inhibitors of cyclin-dependent kinases based on least squares support vector machines   [0588] 
Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier   [0588] 
Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs   [0588] 
Caspase inhibitors prevent cisplatin-induced apoptosis of auditory sensory cells   [0588] 
In vivo generation of immature inner hair cells in neonatal mouse cochleae by ectopic Atoh1 expression   [0588] 
A new series of potent oxindole inhibitors of CDK2   [0588] 
Ebselen-mediated protection from single and repeated noise exposure in rat   [0588] 
Compounds for the prevention and treatment of noise-induced hearing loss   [0588] 
Efferent protection from acoustic injury is mediated via alpha9 nicotinic acetylcholine receptors on outer hair cells   [0588] 
Overexpression of SK2 channels enhances efferent suppression of cochlear responses without enhancing noise resistance   [0588] 
CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response   [0588] 
Drug delivery for treatment of inner ear disease: current state of knowledge   [0588] 
Conditioning-induced protection from impulse noise in female and male chinchillas   [0588] 
Differential activation of mitogen-activated protein kinases and brain-derived neurotrophic factor after temporary or permanent damage to a sensory system   [0588] 
Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma   [0588] 
The design and screening of drugs to prevent acquired sensorineural hearing loss   [0588] 
New treatment options for hearing loss   [0588] 
Emerging treatments for noise-induced hearing loss   [0588] 
Cisplatin-induced hair cell loss in zebrafish (Danio rerio) lateral line   [0588] 
Drug screening for hearing loss: using the zebrafish lateral line to screen for drugs that prevent and cause hearing loss   [0588] 
Response of mechanosensory hair cells of the zebrafish lateral line to aminoglycosides reveals distinct cell death pathways   [0588] 
Ebselen attenuates cochlear damage caused by acoustic trauma   [0588] 
Dependence of cisplatin-induced cell death in vitro and in vivo on cyclin-dependent kinase 2   [0588] 
Intratympanic steroids for sensorineural hearing loss   [0588] 
Damage of the auditory system associated with acute blast trauma   [0588] 
Sudden sensorineural hearing loss: systemic steroid therapy and the risk of glucocorticoid-induced hyperglycemia   [0588] 
Ototoxicity   [0588] 
Noise-induced time-dependent changes in oxidative stress in the mouse cochlea and attenuation by D-methionine   [0588] 
A dual role of Cdk2 in DNA damage response   [0588] 
Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention   [0588] 
Scaffold composition and biological relevance of screening libraries   [0588] 
Retinoic acid applied after noise exposure can recover the noise-induced hearing loss in mice   [0588] 
Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases   [0588] 
Intratympanic treatment of acute acoustic trauma with a cell-permeable JNK ligand: a prospective randomized phase I/II study   [0588] 
Inner ear drug delivery for auditory applications   [0588] 
Drug delivery to the cochlea using PLGA nanoparticles   [0588] 
Protection against cisplatin- induced ototoxicity by N-acetylcysteine in a rat model   [0588] 
GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors   [0588] 
Current pharmacologic otoprotective agents in or approaching clinical trials: how they elucidate mechanisms of noise-induced hearing loss   [0588] 
Protective effect of calcineurin inhibitors on acoustic injury of the cochlea   [0588] 
Screen of FDA-approved drug library reveals compounds that protect hair cells from aminoglycosides and cisplatin   [0588] 
Integrity and regeneration of mechanotransduction machinery regulate aminoglycoside entry and sensory cell death   [0588] 
Dexamethasone suppresses cochlear Hes1 expression after noise exposure   [0588] 
Dynamics of noise-induced cellular injury and repair in the mouse cochlea   [0588] 
Hearing threshold elevation precedes hair-cell loss in prestin knockout mice   [0588] 
Normal hearing sensitivity at low- to-middle frequencies with 34% prestin-charge density   [0588] 
Ebselen prevents noise-induced excitotoxicity and temporary threshold shift   [0588] 
Gfi1-Cre knock-in mouse line: A tool for inner ear hair cell-specific gene deletion   [0588] 
A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS   [0588] 
Discovery and initial characterization of the paullones, a novel class of small- molecule inhibitors of cyclin-dependent kinases   [0588] 
Pifithrin-alpha suppresses p53 and protects cochlear and vestibular hair cells from cisplatin-induced apoptosis   [0588] 
Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses   [0588]