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WO2015069192A   [0003] 
EP2496687A   [0003] 
EP2496687B1   [0013]  [0013] 
EP15198421   [0049] 

Computational Molecular Biology   [0024] 
Biocomputing: Informatics and Genome Projects   [0024] 
Computer Analysis of Sequence Data   [0024] 
Sequence Analysis in Molecular Biology   [0024] 
Sequence Analysis Primer   [0024] 
SIAM J. Applied Math.   [0024] 
Nucleic Acids Research   [0024] 
J. Mol. Biol.   [0024] 
J. Mol. Biol.   [0024] 
J. Mol. Biol.   [0024]  [0024] 
Proc. Natl. Acad. Sci. USA.   [0024] 
Molecular Cloning, A Laboratory Manual   [0029] 
Molecular Cloning: A Laboratory Manual   [0029] 
Current Protocols in Molecular Biology, Current Protocols   [0029] 
Molecular Biology LabFax   [0029] 
Oligonucleotide Synthesis   [0029] 
Nucleic Acid Hybridization   [0029] 
Drug-induced nephrotoxicity: clinical impact and preclinical in vitro models   [0048] 
Impact and frequency of different toxicities throughout the pharmaceutical life cycle   [0048] 
Mechanisms of drug toxicity and relevance to pharmaceutical development   [0048] 
Extrahepatic metabolism at the body's internal-external interfaces   [0048] 
Renal organic anion transporters (SLC22 family): expression, regulation, roles in toxicity, and impact on injury and disease   [0048] 
In vitro and in vivo evidence of the importance of organic anion transporters (OATs) in drug therapy   [0048] 
Therapeutic implications of renal anionic drug transporters   [0048] 
Organic cation transporter OCTs (SLC22) and MATEs (SLC47) in the human kidney   [0048] 
Transporters and drug-drug interactions: important determinants of drug disposition and effects   [0048] 
The nephrotoxic effects of HAART   [0048] 
Mitochondrial toxicity of NRTI antiviral drugs: an integrated cellular perspective   [0048] 
Antiviral drugs in current clinical use   [0048] 
Tenofovir effect on the kidneys of HIV-infected patients: a double-edged sword?   [0048] 
Tenofovir renal proximal tubular toxicity is regulated by OAT1 and MRP4 transporters   [0048] 
Human organic anion transporters and human organic cation transporters mediate renal antiviral transport   [0048] 
The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1   [0048] 
Effect of oral probenecid coadministration on the chronic toxicity and pharmacokinetics of intravenous cidofovir in cynomolgus monkeys   [0048] 
Tenofovir disoproxil fumarate: clinical pharmacology and pharmacokinetics   [0048] 
Emerging clinical issues related to management of multiorgan comorbidities and polypharmacy   [0048] 
Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters   [0048] 
Cationic uremic toxins affect human renal proximal tubule cell functioning through interaction with the organic cation transporter   [0048] 
Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration   [0048] 
A morphological and functional comparison of proximal tubule cell lines established from human urine and kidney tissue   [0048] 
A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression   [0048] 
Mesenchymal stem cell-conditioned medium accelerates regeneration of human renal proximal tubule epithelial cells after gentamicin toxicity   [0048] 
Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1   [0048] 
Guidance for Industry   [0048] 
Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1   [0048] 
Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates   [0048] 
Membrane transport function in primary cultures of human proximal tubular cells   [0048] 
Characterisation of human tubular cell monolayers as a model of proximal tubular xenobiotic handling   [0048] 
hTERT alone immortalizes epithelial cells of renal proximal tubules without changing their functional characteristics   [0048] 
Expression of xenobiotic transporters in the human renal proximal tubule cell line RPTEC/TERT1   [0048] 
Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine   [0048] 
Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation   [0048] 
Potential for food-drug interactions by dietary phenolic acids on human organic anion transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11)   [0048] 
Intracellular concentrations determine the cytotoxicity of adefovir, cidofovir and tenofovir   [0048] 
Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir   [0048] 
Physicochemical determinants of human renal clearance   [0048] 
Pharmacokinetics and bioavailability of zidovudine in humans   [0048] 
What do drug transporters really do?   [0048] 
EMA   [0048] 
Membrane transporters in drug development   [0048] 
CRACK IT Challenge winners awarded £4.9 million to further their research   [0048] 
Species differences in drug transporters and implications for translating preclinical findings to humans   [0048] 
Microfluidic organs-on-chips   [0048] 
Characterization of ochratoxin A transport by human organic anion transporters   [0048] 
Characterization of uremic toxin transport by organic anion transporters in the kidney   [0048] 
Interactions of stevioside and steviol with renal organic anion transporters in S2 cells and mouse renal cortical slices   [0048] 
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney   [0048] 
Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein   [0048] 
Interactions of human organic anion transporters with diuretics   [0048] 
Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A)   [0048] 
Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs   [0048] 
Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1   [0048] 
Anti-human immunodeficiency virus (HIV) activity, safety, and pharmacokinetics of adefovir dipivoxil (9-[2-(bis-pivaloyloxymethyl)-phosphonylmethoxyethyl]adenine) in HIV-infected patients   [0048] 
Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients   [0048] 
Pharmacokinetics, safety and bioavailability of HPMPC (cidofovir) in human immunodeficiency virus-infected subjects   [0048] 
Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients   [0048] 
Systemic and renal pharmacokinetics of adefovir and tenofovir upon coadministration   [0048] 
Pharmacokinetics and safety of single-dose tenofovir disoproxil fumarate and emtricitabine in HIV-1-infected pregnant women and their infants   [0048] 
Pharmacokinetics and bioavailability of zidovudine and its glucuronidated metabolite in patients with human immunodeficiency virus infection and hepatic disease (AIDS Clinical Trials Group protocol 062)   [0048] 
Endogenous gene and protein expression of drug-transporting proteins in cell lines routinely used in drug discovery programs   [0048] 
Sodium-sensitive, probenecid-insensitive p-amino-hippuric acid uptake in cultured renal proximal tubule cells of the rabbit   [0048]