Description  Claims  Drawing  Cited references 

US8039429B   [0014]  [0015] 
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US61836516B   [0167] 

Immune Evasion by Staphylococci   [0003] 
Staphylococcus aureus Hemolysins, Bi-Component Leukocidins, and Cytolytic Peptides: A Redundant Arsenal of Membrane-Damaging Virulence Factors?   [0003]  [0004]  [0011]  [0147]  [0147]  [0152] 
Neutrophils in Innate Host Defense Against Staphylococcus aureus Infections   [0003]  [0008] 
Crystal Structure of the Octameric Pore of Staphylococcal Gamma-Hemolysin Reveals the Beta-Barrel Pore Formation Mechanism by Two Components   [0004] 
Bacterial Survival Amidst an Immune Onslaught: The Contribution of the Staphylococcus aureus Leukotoxins   [0004]  [0004]  [0011]  [0011]  [0152] 
Characterization of a Novel Structural Member, LukE-LukD, of the Bi-Component Staphylococcal Leucotoxins Family   [0004]  [0011] 
Purification, Cloning and Characterization of Variant LukE-LukD With Strong Leukocidal Activity of Staphylococcal Bi-Component Leukotoxin Family   [0004]  [0004]  [0011]  [0011]  [0147] 
Cross-Talk Between Staphylococcus aureus Leukocidins-Intoxicated Macrophages and Lung Epithelial Cells Triggers Chemokine Secretion in an Inflammasome-Dependent Manner   [0004]  [0011] 
Staphylococcus aureus Fur Regulates the Expression of Virulence Factors That Contribute to the Pathogenesis of Pneumonia   [0004]  [0011] 
Methicillin-Resistant S. aureus Infections Among Patients in the Emergency Department   [0011] 
Invasive Methicillin-Resistant Staphylococcus aureus Infections in the United States   [0011] 
Changes in the Epidemiology of Methicillin-Resistant Staphylococcus aureus in Intensive Care Units in US Hospitals, 1992-2003   [0011] 
Community-Associated Methicillin-Resistant Staphylococcus aureus   [0011] 
Insights into Mechanisms Used by Staphylococcus aureus to Avoid Destruction by Human Neutrophils   [0011] 
Identification of Novel Cytolytic Peptides as Key Virulence Determinants for Community-Associated MRSA   [0011]  [0011] 
Evolution of Virulence in Epidemic Community-Associated Methicillin-Resistant Staphylococcus aureus   [0011] 
Characterization of a New Cytotoxin That Contributes to Staphylococcus aureus Pathogenesis   [0011] 
Staphylococcus aureus Leucocidin ED Contributes to Systemic Infection by Targeting Neutrophils and Promoting Bacterial Growth in Vivo   [0011]  [0011] 
Characterization of a New Cytotoxin That Contributes to Staphylococcus aureus Pathogenesis   [0011]  [0128]  [0147] 
Staphylococcus aureus Panton-Valentine Leukocidin is a Very Potent Cytotoxic Factor for Human Neutrophils   [0011]  [0147]  [0147] 
Identification of a Novel Staphylococcus aureus Two-Component Leukotoxin Using Cell Surface Proteomics   [0011]  [0147] 
CXCL8(3-74)K11R/G31P Antagonizes Ligand Binding to the Neutrophil CXCR1 and CXCR2 Receptors and Cellular Responses to CXCL8/IL-8   [0014] 
Noncompetitive Allosteric Inhibitors of the Inflammatory Chemokine Receptors CXCR1 and CXCR2: Prevention of Reperfusion Injury   [0025] 
ELR+ CXC Chemokines and Their Receptors (CXC Chemokine Receptor 1 and CXC Chemokine Receptor 2) as New Therapeutic Targets   [0025] 
Repertaxin, A Novel Inhibitor of Rat CXCR2 Function, Inhibits Inflammatory Responses that Follow Intestinal Ischaemia and Reperfusion Injury   [0025] 
Small-Molecule Antagonists for CXCR2 and CXCR1 Inhibit Human Melanoma Growth by Decreasing Tumor Cell Proliferation, Survival, and Angiogenesis   [0027] 
Identification of a Potent, Selective Non-Peptide CXCR2 Antagonists That Inhibits Interleukin-8-Induced Neutrophil Migration   [0028] 
A Potent and Selective Nonpeptide Antagonist of CXCR2 Inhibits Acute and Chronic Models of Arthritis in the Rabbit   [0028] 
CXCR1 Blockade Selectively Targets Human Breast Cancer Stem Cells In Vitro and In Xenografts   [0029] 
Functional Contribution of CXCR2 to Lung Injury After Aspiration of Acid and Gastric Particulates   [0029] 
Expression of the Duffy Antigen/Receptor for Chemokines (DARC) by the Inflamed Synovial Endothelium   [0031] 
MERCK MANUAL OF DIAGNOSIS AND THERAPY   [0037] 
REMINGTON'S PHARMACEUTICAL SCIENCES   [0040]  [0086] 
Selection and Identification of Single Domain Antibody Fragments from Camel Heavy-Chain Antibodies   [0063] 
Properties, Production, and Applications of Camelid Single-Domain Antibody Fragments   [0063] 
Domain Antibodies: Proteins for Therapy   [0063] 
Maraviroc, a CCR5 Antagonist, Prevents Development of Hepatocellular Carcinoma in a Mouse Model   [0113] 
The CCL5/CCR5 Axis Promotes Metastasis in Basal Breast Cancer   [0113] 
CCR5 Antagonist Blocks Metastasis of Basal Breast Cancer Cells   [0113] 
Deficiency of C-C Chemokine Receptor 5 Suppresses Tumor Development Via Inactivation of NF-κB and Inhibition of Monocyte Chemoattractant Protein-1 in Urethane-Induced Lung Tumor Model   [0113] 
Structure Activity Relationship Studies of Natural Product Chemokine Receptor CCR5 Antagonist Anibamine Toward the Development of Novel Anti-Prostate Cancer Agents   [0113] 
Anti-Angiogenic Therapeutic Drugs for the Treatment of Human Cancer   [0116] 
Cytokine Signals Through PI-3 Kinase Pathway Modulate Th17 Cytokine Production by CCR6+ Human Memory T Cells   [0121] 
CCR5 is a Receptor for Staphylococcus aureus Leukotoxin ED   [0124]  [0133]  [0141]  [0143]  [0147]  [0147]  [0147]  [0148]  [0153]  [0159]  [0160]  [0160]  [0161]  [0161]  [0161]  [0161] 
Staphylococcus aureus Leucocidin ED Contributes to Systemic Infection by Targeting Neutrophils and Promoting Bacterial Growth in Vivo   [0128]  [0135]  [0135]  [0135]  [0136]  [0137]  [0138]  [0147]  [0160]  [0161] 
Mol. Microbiol.   [0133]  [0133] 
Nature   [0133] 
PNAS   [0133]  [0133] 
The Staphylococcus aureus LukAB Cytotoxin Kills Human Neutrophils by Targeting the CD11b Subunit of the Integrin Mac-1   [0138]  [0147] 
Reemergence of Antibiotic-Resistant Staphylococcus aureus in the Genomics Era   [0147] 
Understanding How Leading Bacterial Pathogens Subvert Innate Immunity to Reveal Novel Therapeutic Targets   [0147] 
Bacterial Survival Amidst an Immune Onslaught: The Contribution of the Staphylococcus aureus Leukotoxins   [0147] 
Staphylococcal Toxin   [0147] 
Staphylococcus aureus Panton-Valentine Leukocidin Causes Necrotizing Pneumonia   [0147] 
Crystal Structure of the Octameric Pore of Staphylococcal Gamma-Hemolysin Reveals the Beta-Barrel Pore Formation Mechanism by Two Components   [0147] 
Staphylococcus aureus Bicomponent Gamma-Hemolysins, HlgA, HlgB, and HlgC, Can Form Mixed Pores Containing All Components   [0147] 
Characterization of a Novel Structural Member, LukE-LukD, of the Bi- Component Staphylococcal Leucotoxins Family   [0147] 
Staphylococcus aureus Elaborates Leukocidin AB to Mediate Escape From Within Human Neutrophils   [0147] 
The Staphylococcal Toxin Panton-Valentine Leukocidin Targets Human C5a Receptors   [0147]  [0149] 
Identification of a CCR5-Expressing T Cell Subset That is Resistant to R5-Tropic HIV Infection   [0147] 
The Functional Significance Behind Expressing Two IL-8 Receptor Types on PMN   [0150]  [0150]  [0150] 
The CXCR1 Tail Mediates Beta1 Integrin-Dependent Cell Migration Via MAP Kinase Signaling   [0151] 
Neutrophils in Innate Host Defense Against Staphylococcus aureus Infections   [0153]  [0161] 
Differential Activation and Regulation of CXCR1 and CXCR2 by CXCL8 Monomer and Dimer   [0154]  [0154] 
The Functional Significance Behind Expressing Two IL-8 Receptor Types on PMN   [0154] 
Chemokine: Receptor Structure, Interactions, and Antagonism   [0154] 
The Staphylococcal Toxin Panton-Valentine Leukocidin Targets Human C5a Receptors   [0155] 
Ion Channels and Bacterial Infection: The Case of Beta-Barrel Pore-Forming Protein Toxins of Staphylococcus aureus   [0155] 
IL-17 is Essential for Host Defense Against Cutaneous Staphylococcus aureus Infection in Mice   [0161] 
Th1-Th17 Cells Mediate Protective Adaptive Immunity Against Staphylococcus aureus and Candida Albicans Infection in Mice   [0161] 
Staphylococcus aureus Leucocidin ED Contributes to Systemic Infection by Targeting Neutrophils and Promoting Bacterial Growth In Vivo   [0164] 
CCR5 Is a Receptor for Staphylococcus aureus Leukotoxin ED   [0164] 
Staphylococcus aureus Leukotoxin ED Targets the Chemokine Receptors CXCR1 and CXCR2 to Kill Leukocytes and Promote Infection   [0164]  [0164]