Description  Claims  Drawing  Cited references 

US62345641   [0001] 
US62345697B   [0001] 
US62346374   [0001] 
EP1992705A1   [0006] 

Methods   [0006] 
Analytical and Bioanalytical Chemistry   [0006] 
Fluorescent Energy Transfer Nucleic Acid Probes: Designs and Protocols   [0024] 
Nucl. Acids Res   [0024] 
Immunoassay Methods   [0268] 
Enzyme Immunoassay and Enzyme-Linked Immunosorbent Assay   [0268] 
Enzyme Immunoassay (EIA)/Enzyme-Linked Immunosorbent Assay (ELISA)   [0268]  [0268] 
Recent Progress in Noncompetitive Hapten Immunoassays: A review   [0268] 
Sensitivity and Specificity: Twin Goals of Proteomics Assays   [0268]  [0268] 
Enhanced Sensitive Immunoassay'' Noncompetitive Phage AntiImmune Complex Assay for the Determination of Malachite Green and Leucomalachite Green   [0268] 
Open-Sandwich Enzyme Immunoassay for One-Step Noncompetitive Detection of Corticosteroid 11-Deoxycortisol   [0268]  [0268] 
Recent Development of Sandwich Assay based on Nanobiotechnologies for Proteins, Nucleic Acids, Small Molecules, and Ions   [0268] 
New Technologies Provide Quantum Changes in the Scale, Speed, and Success of SELEX Methods and Aptamer Characterization   [0268]  [0268] 
Challenges and opportunities for small molecule aptamer development   [0268] 
Nucleic Acid Ligands with Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents   [0268] 
In vitro selection of RNA molecules that bind specific ligands   [0268] 
Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase   [0268]  [0268] 
Applications of Aptamers as Sensors   [0268]  [0268] 
Aptamers as therapeutics   [0268] 
Optimizing Cros-reactivity with Evolutionary Search for Sensors   [0268] 
Capture-SELEX: Selection of DNA Aptamers for Aminoglycoside Antibiotics   [0268] 
Selection of fluorescent aptamer beacons that light up in the presence of zinc   [0268]  [0268] 
In vitro selection of structure-switching signaling aptamers   [0268] 
A simple and rapid approach for measurement of dissociation constants of DNA aptamers against proteins and small molecules via automated microchip electrophoresis   [0268] 
Structure-switching signaling aptamers   [0268] 
Toward third-generation aptamers: Spiegelmers and their therapeutics prospects   [0268]  [0268] 
Turning mirror-image oligonucleotides into drugs: the evolution of Spiegelmer therapeutics   [0268] 
Bioactive and Nuclease-resistant L-DNA Ligand of Vasopressin   [0268] 
An L-RNA-based aquaretic agent that inhibits vasopressin in vivo   [0268] 
Recognition and Sensing of Low-Epitope Targets via Ternary Complexes with Oligonucleotides and Synthetic Receptors   [0268] 
Challenges and opportunities for small molecule aptamer development   [0268] 
Nucleic Acid Ligands with Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents   [0268] 
In vitro selection of RNA molecules that bind specific ligands   [0268] 
Selection in vitro of an RNA enzyme that specifically cleaves singlestranded DNA   [0268] 
Aptamers as therapeutics   [0268] 
Supramolecular Analytical Chemistry   [0268] 
Supramolecular Chemistry in Water   [0268] 
Supramolecular Chemistry: From Molecules to Nanomaterials   [0268] 
Supramolecular Chemistry   [0268] 
Cyclic polyethers and their complexes with metal salts   [0268] 
Chiral, hinged, and functionalized multiheteromacrocycles   [0268] 
Diaza-polyoxa- macrocycles et macrobicycles   [0268] 
Thermodynamics and kinetics of adaptive binding in the malachite green RNA aptamer   [0268] 
Adaptive Recognition by Nucleic Acids   [0268] 
Conformational dynamics of an ATP-binding DNA aptamer: a single molecule study   [0268] 
Turning mirror-image oligonucleotides into drugs: the evolution of Spiegelmer therapeutics   [0268] 
Bioactive and Nuclease-resistant L-DNA Ligand of Vasopressin.   [0268] 
An L-RNA-based aquaretic agent that inhibits vasopressin in vivo.   [0268] 
Interaction of three-way DNA junctions with steroids   [0268] 
Cross-reactive arrays based on three-way junctions   [0268] 
Optimizing Cros-reactivity with Evolutionary Search for Sensors   [0268] 
Sepsis: multiple abnormalities, heterogenous responses, and evolving understanding   [0268] 
Arterial norepinephrine changes in patients with septic shock   [0268] 
Elevated plasma vasopressin concentrations during endotoxin and E. coli shock   [0268] 
Vasopressin deficiency contributes to the vasodilation of septic shock   [0268] 
Low plasma vasopressin/norepinephrine ratio predicts septic shock   [0268] 
Cortisol levels and mortality in severe sepsis   [0268] 
Finnsepsis Study Group ''Freel cortisol in sepsis and septic shock   [0268] 
Diagnosis of Adrenal Insufficiency in Severe Sepsis and Septic Shock   [0268] 
Aldosterone secretion in patients with septic shock: a prospective study   [0268] 
Modulation of the renin-angiotensin-aldosterone system in sepsis: a new therapeutic approach?   [0268] 
Severe sepsis: Low expression of renin-angiotensin system is associated with poor prognosis   [0268] 
Cardiac troponin and heart failure in the era of high-sensitivity assays   [0268] 
High-Sensitivity Troponin Assays: Evidence, Indications, and Reasonable Use   [0268] 
Immunoassay Methods   [0268] 
Enzyme Immunoassay and Enzyme-Linked Immunosorbent Assay   [0268] 
Recent Progress in Noncompetitive Hapten Immunoassays: A review   [0268] 
Brain Natriuretic Peptide Measurement in Acute Coronary Syndromes   [0268] 
Nucleic acid selection and the challenge of combinatorial chemistry   [0268] 
Theoretical principles of in vitro selection using combinatorial nucleic acid libraries   [0268] 
Enhanced Sensitive Immunoassay'' Noncompetitive Phage AntiImmune Complex Assay for the Determination of Malachite Green and Leucomalachite Green   [0268] 
Recent Development of Sandwich Assay based on Nanobiotechnologies for Proteins, Nucleic Acids, Small Molecules, and Ions   [0268] 
Self-assembling aptameric sensors   [0268] 
DNA and RNA Can Be Equally Efficient Catalysts for Carbon-Carbon Bond Formation   [0268] 
Towards XNA nanotechnology: new materials from synthetic genetic polymers   [0268] 
RNA cleavage by a DNA enzyme with extended chemical functionality   [0268] 
Bridging the gap between proteins and nucleic acids: a metal-independent RNAseA mimic with two protein-like functionalities   [0268] 
Generation of high-affinity DNA aptamers using an expanded genetic alphabet   [0268] 
Efficacy of base-modification on target binding of small molecule DNA aptamers   [0268] 
An in vitro selection scheme for oligonucleotide probes to discriminate between closely related DNA sequences   [0268] 
A protocol for the in vitro selection of specific oligonucleotide probes for high-resolution DNA typing   [0268] 
In vitro selection of oligonucleotides that bind doublestranded DNA in the presence of triplex-stabilizing agents   [0268] 
Aptamers targeted to an RNA hairpin show improved specificity compared to that of complementary oligonucleotides   [0268] 
Riboswitches Based on Kissing Complexes for the Detection of Small Ligands   [0268] 
An aptamer targeting the apical-loop domain modulates pri-miRNA processing   [0268] 
The Molecular Interactions that Stabilize RNA Tertiary Structure: RNA Motifs, Patterns, and Networks   [0268] 
Analysis and classification of RNA tertiary structures   [0268] 
Reconstitution of hairpin ribozyme activity following separation of functional domains   [0268] 
Ribozyme structures and mechanisms   [0268] 
Self-assembled DNA nanostructures for distance dependent multivalent ligand-protein binding   [0268] 
Dynamic combinatorial chemistry   [0268] 
Specific binding of aminoglycoside antibiotics to RNA   [0268] 
Fluorescent Sensors based on aptamer self-assembly   [0268] 
Aptamer-based folding fluorescent sensor for cocaine   [0268] 
Aptamer-based colorimetric sensor for cocaine   [0268] 
Modular allosteric sensors   [0268] 
Capture-SELEX: Selection of DNA Aptamers for Aminoglycoside Antibiotics   [0268] 
In vitro selection of structure-switching signaling aptamers   [0268] 
A simple and rapid approach for measurement of dissociation constants of DNA aptamers against proteins and small molecules via automated microchip electrophoresis   [0268] 
Structure-switching signaling aptamers   [0268] 
Label-free microfluidic characterization of temperature dependent biomolecular interactions   [0268] 
Microfluidic Aptameric Affinity Sensing of Vasopressin for Clinical Diagnostic and Therapeutic Applications   [0268] 
An Aptameric Microfluidic System for Specific Purification, Enrichment and Mass Spectrometric Detection of Biomolecules   [0268] 
Isolation of thermally sensitive protein-binding oligonucleotides on a microchip   [0268] 
Necessary sample size for method comparison studies based on regression analysis   [0268] 
Evaluating Agreement Between Two Analytical Methods in Clinical Chemistry   [0268] 
Performance of Deming regression analysis in case of misspecified analytic error ratio in method comparison studies   [0268] 
Application of the Bland-Altman plot for interpretation of method-comparison studies: a critical investigation of its practice   [0268] 
Determination of Neurotransmitter Levels in Models of Parkinson' s Disease by HPLC-ECD   [0268] 
A more sensitive and specific radioenzymatic assay for catecholamines   [0268] 
Chronic microsensors for longitudinal subsecond dopamine detection in behaving animals   [0268] 
In vitro selection of dopamine RNA ligands   [0268] 
Dopamine-mediated autocrine inhibitory circuit regulating human insulin secretion in vitro   [0268] 
Utilising the left helical conformation of L-DNA for analyzing different marker types on a single universal microarrays platform   [0268] 
Methods   [0268] 
In-Line Probing Analysis of Riboswitches   [0268] 
The Plasma Protein Binding of Amphetamine, Catecholamines and Related Compounds   [0268] 
Normal Hormone Reference Ranges. Greenspan's Basic & Clinical Endocrinology   [0268] 
Plasma Norepinephrine, Epinephrine, and Dopamine Levels in End-Stage Renal Disease   [0268] 
Urine and Plasma Catecholamine and Cortisol Concentrations after Myocardial Revascularization   [0268] 
Mfold web server for nucleic acid folding and hybridization prediction   [0268] 
NUPACK: analysis and design of nucleic acid systems   [0268] 
Development and validation of a highly sensitive LC-MS/MS assay for the quantification of arginine vasopressin in human plasma and urine: Application in preterm neonates and child   [0268] 
Therapeutic Strategies for High-Dose Vasopressor-Dependent Shock   [0268] 
Aldosterone control in critically ill patients: ACTH, metoclopramide, and atrial natriuretric peptide   [0268] 
Serum Aldosterone Concentrations and Urine Output in Oliguric Intensive Care Unit Patients Receiving Low-Dose Dopamine   [0268] 
Circulating Aldosterone Levels are Unexpectedly Low in Children with Actute Meningococcal Disease   [0268] 
The Adrenal Cortex   [0268] 
Dehydroepiisoandreosterone, dehydroepiisoandrosterone-sulfate, and cortisol concentrations in intensive care unit patients   [0268] 
Dehydroepiandrosterone sulphate in critical illness: effect of dopamine   [0268]