Abstract     Description     Claims     Drawing  

US61844844   [0001] 

CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III   [0003]  [0129] 
Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria   [0003]  [0129] 
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity   [0003]  [0129] 
The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli   [0003] 
CRISPR-Cas systems in bacteria and archaea: versatile small RNAs for adaptive defense and regulation   [0003]  [0129] 
Phage response to CRISPR-encoded resistance in Streptococcus thermophilus   [0003] 
Nature Reviews, Microbiology   [0056]  [0061] 
Science   [0061]  [0064] 
Nature   [0062] 
Nature Biotechnology   [0070] 
Current Biology   [0073] 
Cell   [0075] 
Nature Methods   [0077] 
Nature Methods   [0077] 
Biology of the Cell / Under the Auspices of the European Cell Biology Organization   [0079] 
Nature Biotechnology   [0080] 
Nature Biotechnology   [0081] 
Proceedings of the National Academy of Sciences of the United States of America   [0084] 
Nature Methods   [0084] 
Nature Methods   [0087] 
Nature Protocols   [0098] 
RNA-guided genetic silencing systems in bacteria and archaea   [0129] 
Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease   [0129] 
Multiplex genome engineering using CRISPR/Cas systems   [0129] 
Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs   [0129] 
RNA-guided human genome engineering via Cas9   [0129] 
One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering   [0129] 
RNA-guided editing of bacterial genomes using CRISPR-Cas systems   [0129] 
Breaking the code of DNA binding specificity of TAL-type III effectors   [0129] 
3rd ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering   [0129] 
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases   [0129] 
Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain   [0129] 
A simple cipher governs DNA recognition by TAL effectors   [0129] 
Gene targeting using zinc finger nucleases   [0129] 
Highly efficient endogenous human gene correction using designed zinc-finger nucleases   [0129] 
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression   [0129] 
3rd Positive and negative regulation of endogenous genes by designed transcription factors   [0129] 
Determinants of specificity in two-component signal transduction   [0129] 
The second wave of synthetic biology: from modules to systems   [0129] 
Diversity, activity, and evolution of CRISPR loci in Streptococcus thermophilus   [0129] 
Processing-Independent CRISPR RNAs Limit Natural Transformation in Neisseria meningitidis   [0129] 
Enzymatic assembly of DNA molecules up to several hundred kilobases   [0129] 
Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system   [0129] 
JCat: a novel tool to adapt codon usage of a target gene to its potential expression host   [0129]