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2010-12-08T16:16:43+01:00
2010-11-22T22:39:06Z
2010-12-08T16:16:43+01:00
Jouve S.A., EPO - Publication - KB, TaggedPDF v1.27
EP-0009054-A1-19800402
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EP-0009054-A1-19800402
The case involves N-pyrazinecarbonyl-N'-substituted- sulfamoylguanidines and processes for making the same. The compounds are depicted in formular I.whereinR' is hydrogen, lower alkyl having from 1 to 5 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms, lower alkenyl having from 2 to 3 carbon atoms;R2 is hydrogen, lower alkyl having from 1 to 5 carbon atoms;R1 and R2 can be joined to form, with the nitrogen atom to which they are attached, a heterocyclic ring having 3 to 6 carbon atoms therein;R2 is hydrogen, lower alkyl having from 1 to 5 carbon atoms;R4 is hydrogen, lower alkyl having from 1 to 5 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms;R5 is hydrogen, lower alkyl having from 1 to 5 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms;X is halo; and the pharmaceutically acceptable non-toxic acid addition salts thereof.The compounds are excellent eukalemic agents possessing diuretic and natriuretic properties.
The case involves N-pyrazinecarbonyl-N'-substituted- sulfamoylguanidines and processes for making the same. The compounds are depicted in formular I.whereinR' is hydrogen, lower alkyl having from 1 to 5 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms, lower alkenyl having from 2 to 3 carbon atoms;R2 is hydrogen, lower alkyl having from 1 to 5 carbon atoms;R1 and R2 can be joined to form, with the nitrogen atom to which they are attached, a heterocyclic ring having 3 to 6 carbon atoms therein;R2 is hydrogen, lower alkyl having from 1 to 5 carbon atoms;R4 is hydrogen, lower alkyl having from 1 to 5 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms;R5 is hydrogen, lower alkyl having from 1 to 5 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms;X is halo; and the pharmaceutically acceptable non-toxic acid addition salts thereof.The compounds are excellent eukalemic agents possessing diuretic and natriuretic properties.
en
European Patent Office
EP0009054
EP 0009054
C07D 241/32
A61K 31/495
N-Pyrazinecarbonyl-N'-substituted-sulfamoyl-guanidine and processes for preparing same
N-Pyrazinecarbonyl-N'-substituted-sulfamoyl-guanidine and processes for preparing same - European Patent Office - EP 0009054 A1
N-Pyrazinecarbonyl-N'-substituted-sulfamoyl-guanidine and processes for preparing same - European Patent Office - EP 0009054 A1
Adobe PDF Library 8.0
"EP0009054"; "EP 0009054"; "C07D 241/32"; "A61K 31/495"; "N-Pyrazinecarbonyl-N'-substituted-sulfamoyl-guanidine and processes for preparing same"
1.4
1
B
18
EP
0009054
A1
1980-04-02
78100928
1978-09-19
C07D 241/32
A61K 31/495
Merck Co., Inc.
Cragoe, Edward Jethro, Jr.
Woltersdorf, Otto William, Jr.
Abitz, Walter, Dr.-Ing. et al
N-Pyrazinecarbonyl-N'-substituted-sulfamoyl-guanidine and processes for preparing same
N'-substituierte N-Pyrazincarbonyl-sulfamoylguanidine und Verfahren zu ihrer Herstellung
N-Pyrazinecarbonyl-N'-substituted-sulfamoyl-guanidine and processes for preparing same
N-Pyrazinecarbonyl-sulfamoylguanidines substituées en N' et procédés pour leur préparation
The case involves N-pyrazinecarbonyl-N'-substituted- sulfamoylguanidines and processes for making the same. The compounds are depicted in formular I.whereinR' is hydrogen, lower alkyl having from 1 to 5 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms, lower alkenyl having from 2 to 3 carbon atoms;R2 is hydrogen, lower alkyl having from 1 to 5 carbon atoms;R1 and R2 can be joined to form, with the nitrogen atom to which they are attached, a heterocyclic ring having 3 to 6 carbon atoms therein;R2 is hydrogen, lower alkyl having from 1 to 5 carbon atoms;R4 is hydrogen, lower alkyl having from 1 to 5 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms;R5 is hydrogen, lower alkyl having from 1 to 5 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms;X is halo; and the pharmaceutically acceptable non-toxic acid addition salts thereof.The compounds are excellent eukalemic agents possessing diuretic and natriuretic properties.
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