BACKGROUND OF THE INVENTION
1. Field of the Invention
[0001] The present invention relates to novel muramyl peptide derivatives. The muramyl peptide
derivatives of the present invention acts on in vivo immunomechanism of human beings
and livestock (in particular cells relevant to immune responses) and are useful as
immunoregulating agents.
2. Description of the Prior Art
[0002] Muramyl peptides are known to possess various biological activities. That is, they
possess in vitro activities such as;
(1) the action on cells related to immune responses (for example, monocytes or macrophages,
B cells, T cells, natural killer (NK) cells and the like),
(2) the action on cells other than those mentioned above (for example, platelets,
endothelial cells, fibroblasts and the like), and
(3) the action which activates complement systems.
[0003] Further they show in vivo activities such as (1) immunoregulating action, and (2)
enhancement of natural resistance [see Saishin Igaku,
43, No. 6, pp. 1268-1276 (1988) in Japan].
[0004] Known muramyl peptide derivatives are, for example, B30-muramyl dipeptide [Kusumoto
et al; Tetrahedron letters,
49 pp. 4899-4902(1978)], muramyl dipetide-lysine [Matsumoto et al, Immunostimulants,
pp. 79-97 (1987)] and those discribed in Japanese Published Unexamined Patent Application
Nos. 172399/1983, 20297/1984 and 275299/1986.
[0005] However, it is still desired to develop compounds other than the known muramyl dipeptide
derivatives which have more excellent activity and less toxicity.
SUMMARY OF THE INVENTION
[0006] According to the present invention, a muramyl dipeptide derivative is provided, which
is represented with the following formula (I):
wherein "Ala" is
"isoGln" is
R₁ is R₃O- or R₃S- [R₃ is
(k is an integer from 8 to 12; q is an integer from 10 to 22) or R₃ is
(m is an integer from 11 to 17; n is an integer from 11 to 17)]; and R₂ is a hydrogen
atom or-CO-(CH₂)
p-CH₃ (p is an integer from 8 to 22).
[0007] The present invention also provides an immunoregulating composition comprising a
compound of the formula (I) and a pharmaceutically acceptable carrier.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
[0008] In the formula (I), examples of the groups R₃ in the group -OR₃ or -SR₃ include 3-dodecanoyloxydodecanoyl,
3-tridecanoyloxydodecanoyl, 3-tetradecanoyloxydodecanoyl, 3-pentadecanoyloxydodecanoyl,
3-hexadecanoyloxydodecanoyl, 3-heptadecanoyloxydodecanoyl, 3- octadecanoyloxydodecanoyl,
3-nonadecanoyloxydodecanoyl, 3-eicosanoyloxydodecanoyl, 3-docosanoyloxydodecanoyl,
3-heneicosanoyloxydodecanoyl, 3-tricosanoyloxydodecanoyl, 3-tetracosanoyloxydodecanoyl,
3-dodecanoyloxytridecanoyl, 3-tridecanoyloxytridecanoyl, 3-tetradecanoyloxytridecanoyl,
3-pentadecanoyloxytridecanoyl, 3-hexadecanoyloxytridecanoyl, 3-heptadecanoyloxytridecanoyl,
3-octadecanoyloxytridecanoyl, 3-nonadecanoyloxytridecanoyl, 3-eicosanoyloxytridecanoyl,
3-docosanoyloxytridecanoyl, 3-heneicosanoyloxytridecanoyl, 3-tricosanoyloxytridecanoyl,
3-tetracosanoyloxytridecanoyl, 3-dodecanoyloxytetradecanoyl, 3-tridecanoyloxytetradecanoyl,
3-tetradecanoyloxytetradecanoyl, 3-pentadecanoyloxytetradecanoyl, 3-hexadecanoyloxytetradecanoyl,
3-heptadecanoyloxytetradecanoyl, 3-octadecanoyloxytetradecanoyl, 3-nonadecanoyloxytetradecanoyl,
3-eicosanoyloxytetradecanoyl, 3-docosanoyloxytetradecanoyl, 3-heneicosanoyloxytetradecanoyl,
3-tricosanoyloxytetradecanoyl, 3-tetracosanoyloxytetradecanoyl, 3-dodecanoyloxypentadecanoyl,
3-tridecanoyloxypentadecanoyl, 3-tetradecanoyloxypentadecanoyl, 3-pentadecanoyloxypentadecanoyl,
3-hexadecanoyloxypentadecanoyl, 3-heptadecanoyloxypentadedanoyl, 3-octadecanoyloxypentadecanoyl,
3-nonadecanoyloxypentadecanoyl, 3-eicosanoyloxypentadecanoyl, 3-docosanoy loxypentadecanoyl,
3-heneicosanoyloxypentadecanoyl, 3-tricosnoyloxypentadecanoyl, 3-tetracosanoyloxypentadecanoyl,
3-dodecanoyloxyhexadecanoyl, 3-tridecanoyloxyhexadecanoyl, 3-tetradecanoyloxyhexadecanoyl,
3-pentadecanoyloxyhexadecanoyl, 3-hexadecanoyloxyhexadecanoyl, 3-heptadecanoyloxyhexadecanoyl,
3-octadecanoyloxyhexadecanoyl, 3-nonadecanoyloxyhexadecanoyl, 3-eicosanoyloxyhexadecanoyl,
3-docosanoyloxyhexadecanoyl, 3-heneicosanoyloxyhexadecanoyl, 3-tricosanoyloxyhexadecanoyl,
3-tetracosanoyloxyhexadecanoyl, 2-dodecyltetradecanoyl, 2-tridecyltetradecanoyl,
2-tetradecyltetradecanoyl, 2-pentadecyltetradecanoyl, 2-hexadecyltetradecanoyl, 2-heptadecyltetradecanoyl,
2-octadecyltetradecanoyl, 2-tetradecylpentadecanoyl, 2-pentadecylpentadecanoyl, 2-hexadecylpentadecanoyl,
2-heptadecylpentadecanoyl, 2-octadecylpentadecanoyl, 2-dodecylhexadecanoyl, 2-tridecylhexadecanoyl,
2-tetradecylhexadecanoyl, 2-pentadecylhexadecanoyl, 2-hexadecylhexadecanoyl, 2-heptadecylhexadecanoyl,
2-octadecylhexadecanoyl, 2-dodecylpentadecanoyl, 2-tridecylpentadecanoyl, 2-tetradecylpentadecanoyl,
2-pentadecylpentadecanoyl, 2-hexadecylpentadecanoyl, 2-heptadecylpentadecanoyl, 2-octadecylpentadecanoyl,
2-dodecylhexadecanoyl, 2-tridecylhexadecanoyl, 2-tetradecylhexadecanoyl, 2-pentadecylhexadecanoyl,
2-hexadecylhexadecanoyl, 2-heptadecylhexadecanoyl, 2-octadecylhexadecanoyl, 2-dodecylheptadecanoyl,
2-tridecylheptadecanoyl, 2-tetradecylheptadecanoyl, 2-pentadecylheptadecanoyl, 2-hexadecylheptadecanoyl,
2-octadecylheptadecanoyl, 2-dodecylocta- decanoyl, 2-tridecyloctadecanoyol, 2-tetradecylocta-
decanoyl, 2-pentadecyloctadecanoyl, 2-hexadecylocta- decanoyl, 2-heptadecyloctadecanoyl,
2-octadecylocta- decanoyl, 2-dodecylnonadecanoyl, 2-tridecylnona- decanoyl, 2-tetradecylnonadecanoyl,
2-pentadecylnona- decanoyl, 2-hexadecylnonadecanoyl, 2-heptadecylnona- decanoyl, 2-octadecylnonadecanoyl,
2-dodecyleicosanoyl, 2-tridecyleicosanoyl, 2-tetradecyleicosanoyl, 2-pentadecyleicosanoyl,
2-hexadecyleicosanoyl, 2-heptadecyleicosanoyl and 2-octadecyleicosanoyl groups.
[0009] Preferred groups of R₃ are 3-tetradecanoyloxytetradecanoyl, 3-hexadecanoyloxytetradecanoyl,
3-octadecanoyloxytetradecanoyl, 3-tetracosanoyloxytetradecanoyl and 2-tetradecylhexadecanoyl
groups.
[0010] Examples of R₂ include hydrogen atom, decanoyl, undecanoyl, dodecanoyl, tridecanoyl,
tetradecanoyl, pentadecanoyl, hexadecanoyl, heptadecanoyl, octadecanoyl, nonadecanoyl,
eicosanoyl, docosanoyl, heneicosanoyl, tricosanoyl and tetracosanoyl groups.
[0011] R₂ is preferably hydrogen atom or tetradecanoyl group.
[0012] Preferably, "Ala" is an L-alanine residue, and "isoGln" is a residue derivated from
D-isoglutamine.
[0013] The compounds of the formula (I) of the present invention are basically muramyl dipeptide
derivatives, in which the muramyl dipeptide moiety has preferably the same steric
configuration as that of the muramyl dipeptide moiety in natural muramyl dipeptides.
Namely, the moieties of muraminic acid and dipeptide in the present muramyl dipeptides
have D-steric configuration and L-alanine-D-isoglutamine configuration, respectively.
However, the muramyl dipeptides of the present invention may be those having other
possible steric configurations.
[0014] The group -OR₃ or -SR₃ in the definition of the formula (I) preferably combines with
the saccharide moiety in the form of α-bond and β-bond, respectively.
[0015] The acyloxyacyl group in R₃ has an asymmetric carbon atom and may be in the form
of D- or L-isomer, or racemic mixture.
[0016] Interesting compounds belonging to the formula (I) in the present invention include:
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-(2-tetradecylhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0(2-tetradecylhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-tetradecanoyl-1-0-(2-tetradecylhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-0-(2-tetradecylhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-(2-tetradecylhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-(2-tetradecylhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-tetradecanoyl-1-S-(2-tetradecylhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-S-(2-tetradecylhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-tetradecanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-((3R)-3-tetradecanolyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-tetradecanoyl-1-0-((3R)-3-tetradecanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-0-((3R)-3-tetradecanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-tetradecanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-((3R)-3-tetradecanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-tetradecanoyl-1-S-((3R)-3-tetradecanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-S-((3R)-3-tetradecanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-hexadecanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-((3R)-3-hexadecanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-hexadecanoyloxytetradecanoyl-6-0-tetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-hexadecanoyloxytetradecanoyl)-6-0-octadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-hexadecanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-((3R)-3-hexadecanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-hexadecanoyloxytetradecanoyl)-6-0-tetradecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-hexadecanoyloxytetradecanoyl)-6-0-octadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-octadecanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-((3R)-3-hexadecanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-octadecanoyloxytetradecanoyl)-6-0-tetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-0-((3R)-3-octadecanoyloxytetradecanoyl)-α-D-gluco
pyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-octadecanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutmine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-((3R)-3-octadecanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-octadecanoyloxytetradecanoyl)-6-0-tetradecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-S-((3R)-3-octadecanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-tetracosanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-((3R)-3-tetracosanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-tetracosanoyloxytetradecanoyl)-6-0-tetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-0-((3R)-3-tetracosanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-tetracosanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-((3R)-tetracosanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-tetracosanoyloxytetradecanoyl)-6-0-tetradecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-S-((3R)-3-tetracosanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-(2-tetradecylhexadecanoyl)-α-D-glucopyranos-3-yl}-d-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-0-(2-tetradecylhexadecanoyl)-α-D-glucpyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-(2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-S-(2-tetradecylhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methyester
N-[2-0-(2-Acetamido-2,3-dideoxy-6-0-hyxadecanoyl-1-S-(2-tetradecylhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methyester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-dodecanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-((3R)-3-dodecanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-((3R)-dodecanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-dodecanoyloxytetradecanoyl)-6-0-tetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-dodecanoyloxytetradecanoyl)-6-0-hexadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-dodecanoyloxytetradecanoyl)-6-0-octadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-dodecanoyloxytetradecnaoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-((3R)-3-dodecanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-S-((3R)-3-dodecanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-dodecanoyloxytetradecanoyl)-6-0-tetradecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-dodecanoyloxytetradecanoyl)-6-0-hexadecanoyl-1-thio-β-
D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-dodecanoyloxytetradecanoyl-6-0-octadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-dodecanoyl-1-0-((3R)-3-tetradecanoyloxytetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-0-((3R)-3-tetradecanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-S-((3R)-3-tetradecanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-S-((3R)-3-tetradecanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1- 0-((3R)-3-hexadecanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-0-((3R)-3-hexadecanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-S-((3R)-3-hexadecanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-S-((3R)-3-hexadecanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-((3R)-3-hexadecanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-0-((3R)-3-octadecanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-S-((3R)-3-octadecanoyloxytetradecanoyl)-1-thio-β-D-
glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine methylester
N-[2-0-(2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-S-((3R)-3-octadecanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-eicosanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-
L-alanyl-D-isoglutamine methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-((3R)-3-eicosanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-((3R)-3-eicosanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-eeicosanoyloxytetradecanoyl)-6-0-tetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-eicosanoyloxytetradecanoyl)-6-0-hexadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-eicosanoyloxytetrdecanoyl)-6-0-octadecanoyl-α-D-gluco
pyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-eicosanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-((3R)-3-eicosanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-((3R)-3-eicosanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-eicosanoyloxytetradecanoyl)-6-0-tetradecanoyl1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-eicosanoyloxytetradecanoyl)-6-0-hexadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-eicosanoyloxytetradecanoyl)-6-0-octadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-docosanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-1-actoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-((3R)-3-docosanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-docosanoyloxytetradecanoyl)-6-0-decanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-docosanoyloxytetradecanoyl)-6-0-tetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-docosanoyloxytetradecanoyl-6-0-hexadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-docosanoyloxytetradecanoyl)-6-0-octadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-docosanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-
3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-docosanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamlne
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-docosanoyloxytetradecanoyl)-6-0-dodecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-docosanoyloxytetradecanoyl)-6-0-tetradecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-docosanoyloxytetradecanoyl)-6-0-hexadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-docosanoyloxytetradecanoyl)-6-0-octadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-((3R)-3-tetracosanoyloxytetradecaoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-0-((3R)-3-tetracosanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-S-((3R)-3-tetracosanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-S-((3R)-3-tetracosanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-(2-dodecyltetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-(2-dodecyltetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamldo-2,3-dideoxy-6-0-dodecanoyl-1-0-(2-dodecyltetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-(2-dodecyltetradecanoyl)-6-0-tetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-(2-dodecyltetradecanoyl)-6-0-hexadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-(2-dodecyltetradecanoyl)-6-0-octadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-(2-dodecyltetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-(2-dodecyltetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-S-(2-dodecyltetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-(2-dodecyltetradecanoyl)-6-0-tetradecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-(2-dodecyltetradecanoyl)-6-0-hexadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-(2-dodecyltetradecanoyl)-6-0-octadecanoyl-1-thio-β-D-gluco
pyranos-3-yl)-D-lactoyl]-L-alanyl-D-isoglutamine methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-(2-hexadecyloctadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-(2-hexadecyloctadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-(2-hexadecyloctadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-(2-hexadecyloctadecanoyl)-6-0-tetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-0-(2-hexadecyloctadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-(2-hexadecyloctadecanoyl)-6-0-octadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-(2-hexadecyloctadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-(2-hexadecyloctadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-S-(2-hexadecyloctadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-(2-hexadecyloctadecanoyl)-6-0-tetradecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-S-(2-hexadecyloctadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-(2-hexadecyloctadecanoyl)-6-0-octadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-(2-octadecyleicosanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-(2-octadecyleisocanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-(2-octadecyleicosanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-(2-octadecyleicosanoyl)-6-0-tetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-0-(2-octadecyleicosanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-0-(2-octadecyleicosanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamlne
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-(2-octadecyleicosanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-(2-octadecyleicosanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-S-(2-octadecyleicosanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-(2-octadecyleicosanoyl)-6-0-tetradecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-S-(2-octadecyleicosanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-S-(2-octadecyleicosanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]
L-alanyl-D-isoglutamine methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-(2-dodecylhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-(2-dodecylhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-(2-dodecylhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-(2-dodecylhexadecanoyl)-6-0-tetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-(2-dodecylhexadecanoyl)-6-0-hexadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-(2-dodecylhexadecanoyl)-6-0-octadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-(2-dodecylhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-(2-dodecylhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-S-(2-dodecylhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-(2-dodecylhexadecanoyl)-6-0-tetradecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-(2-dodecylhexadecanoyl)-6-0-hexadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-(2-dodecylhexadecanoyl)-6-0-octadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-(2-dodecyloctadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-(2-dodecyloctadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-
alanyl-D-isoglutamine methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-(2-dodecyloctadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-(2-dodecyloctadecanoyl)-6-0-tetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-(2-dodecyloctadecanoyl)-6-0-hexadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-(2-dodecyloctadecanoyl)-6-0-octadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-(2-dodecyloctadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-(2-dodecyloctadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-docanoyl-1-S-(2-dodecyloctadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-(2-dodecyloctadecanoyl)-6-0-tetradecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-(2-dodecyloctadecanoyl)-6-0-hexadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-(2-dodecyloctadecanoyl)-6-0-octadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-(2-dodecyleicosanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-(2-dodecyleicosanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-
D-isoglutamine methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-(2-dodecyleicosanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-(2-dodecyleicosanoyl)-6-0-tetradecnaoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-(2-dodecyleicosanoyl)-6-0-hexadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-(2-dodecyleicosanoyl)-6-0-octadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-(2-dodecyleicosanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-(2-dodecyleicosanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-S-(2-dodecyleicosanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-(2-dodecyleicosanoyl)-6-0-tetradecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-(2-dodecyleicosanoyl)-6-0-hexadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-(2-dodecyleicosanoyl)-6-0-octadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-dodecanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-docanoyl-1-0-((3R)-3-dodecanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-((3R)-3-dodecanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-dodecanoyloxydodecanoyl)-6-0-tetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-dodecanoyloxydodecanoyl)-6-0-hexadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-dodecanoyloxydodecanoyl)-6-0-octadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-dodecanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-docanoyl-1-S-((3R)-3-dodecanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-S-((3R)-3-dodecanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-dodecanoyloxydodecanoyl)-6-0-tetradecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-dodecanoyloxydodecanoyl)-6-0-hexadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-dodecanoyloxydodecanoyl)-6-0-octadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-tetradecanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-((3R)-3-tetadecanoyloxydodecanoyl)-α-D-glucopyrano-s-3-
yl}-D-lactoyl]-L-alanyl-D-isoglutamine methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-((3R)-3-tetradecanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-tetradecanoyl-1-0-((3R)-3-ttradecanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-0-((3R)-3-tetradecanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-0-((3R)-3-tetradecanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-tetradecanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-((3R)-3-tetradecanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-S-((3R)-3-tetradecanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-tetradecanoyl- 1-S-((3R)-3-tetradecanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-S-((3R)-3-tetradecanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-S-((3R)-3-tetradecanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-hexadecanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-((3R)-3-hexadecanoyloxydodecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-((3R)-3-hexadecanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-hexadecanoyloxydodecanoyl)-6-0-tetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl1-0-((3R)-3-hexadecanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-hexadecanoyloxydodecanoyl)-6-0-octadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-hexadecanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-((3R)-3-hexadecanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-S-((3R)-3-hexadecanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-hexadecanoyloxydodecanoyl)-6-0-tetradecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-S-((3R)-3-hexadecanoyloxydodecanoyl)-1-thio-β-D-
glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-hexadecanoyloxydodecanoyl)-6-0-octadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-octadecanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido 2,3-dideoxy-6-0-decanoyl-1-0-((3R)-3-octadecanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-((3R)-3-octadecanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-octadecanoyloxydodecanoyl)-6-0-tetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-0-((3R)-3-octadecanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-0-((3R)-3-octadecanoyloxydodecanoyl)-α-D-gluco
pyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-octadecanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-((3R)-3-octadecanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-S-((3R)-3-octadecanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-octadecanoyloxydodecanoyl)-6-0-tetradecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-S-((3R)-3-octadecanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-S-((3R)-3-octadecanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-eicosanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-((3R)-3-eicosanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-((3R)-3-eicosanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-eicosanoyloxydodecanoyl)-6-0-tetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-eicosanoyloxydodecanoyl)-6-0-hexadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-eicosanoyloxydodecanoyl)-6-0-octadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-eicosanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-((3R)-3-eicosanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-S-((3R)-3-eicosanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl)-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-eicosanoyloxydodecanoyl)-6-0-tetradecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-eicosanoyloxydodecanoly)-6-0-hexadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-eicosanoyloxydodecanoyl)-6-0-octadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-docosanoyloxydodecanol)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy--6-0-decanoyl- 1-0-((3R)-3-docosanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-docosanoyloxydodecanoyl)-6-0-dodecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine-methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-docosanoyloxydodecanoyl)-6-0-tetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-docosanoyloxydodecanoyl)-6-0-hexadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-docosanoyloxydodecanoyl)-6-0-octadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-docosanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1- S-((3R)-3-docosanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-docosanoyloxydodecanoyl)-6-0-dodecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-docosanoyloxydodecanoyl)-6-0-tetradecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-docosanoyloxydodecanoyl)-6-0-hexadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-docosanoyloxydodecanoyl)-6-0-octadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-tetracosanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-((3R)-3-tetracosanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-((3R)-3-tetracosanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-tetracosanoyloxydodecanoyl)-6-0-tetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-0-((3R)-3-tetracosanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-0-((3R)-3-tetracosanoyloxydodecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-tetracosanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-((3R)-3-tetracosanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl- 1-S-((3R)-3-tetracosanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-tetracosanoyloxydodecanoyl)-6-0-tetradecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-S-((3R)-tetracosanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-S-((3R)-3-tetracosanoyloxydodecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-dodecanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-((3R)-3-dodecanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-((3R)-3-dodecanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3- dodecanoyloxyhexadecanoyl)-6-0-tetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-dodecanoyloxyhexadecanoyl)-6-0-hexadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-dodecanoyloxyhexadecanoyl)-6-0-octadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-dodecanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-((3R)-dodecanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-S-((3R)-3-dodecanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-dodecanoyloxyhexadecanoyl)-6-0-tetradecanoyl-1-thio-β-
D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-dodecanoyloxyhexadecanoyl)-6-0-hexadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-dodecanoyloxyhexadecanoyl)-6-0-octadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-tetradecanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-((3R)-3-tetradecanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-lsoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-((3R)-3-tetradecanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-tetradecanoyl-1-0-((3R)-3-tetradecanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl- 1-0-((3R)-3-tetradecanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-0-((3R)-3-tetradecanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-tetradecanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-((3R)-3-tetradecanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-S-((3R)-3-tetradecanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-tetradecanoyl-1-S-((3R)-tetradecanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl- 1-S-((3R)-3-tetradecanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-S-((3R)-3-tetradecanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-hexadecanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-((3R)-3-hexadecanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-((3R)-3-hexadecanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-hexadecanoyloxyhexadecanoyl)-6-0-tetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl- 1-0-((3R)-3-hexadecanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-hexadecanoyloxyhexadecanoyl)-6-0-octadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-hexadecanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-((3R)-3-hexadecanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-S-((3R)-3-hexadecanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-hexadecanoyloxyhexadecanoyl)-6-0-tetradecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-S-((3R)-3-hexadecanoyloxyhexadecanoyl)-1-thio-β-D-
glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-hexadecanoyloxyhexadecanoyl)-6-0-octadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-octadecanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-((3R)-3-octadecanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-((3R)-3-octadecanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-octadecanoyloxyhexadecanoyl)-6-0-tetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-0-((3R)-3-octadecanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-0-((3R)-3-octadecanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-octadecanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-((3R)-3-octadecanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-S-((3R)-3-octadecanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-octadecanoyloxyhexadecanoyl)-6-0-tetradecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-S-((3R)-3-octadecanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-S-((3R)-3-octadecanoyloxyhexadecanoyl)-1-thio-β-D-
glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-eicosanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-((3R)-3-eicosanoyloxyhexadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-((3R)-3-eicosanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-eicosanoyloxyhexadecanoyl)-6-0-tetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-eicosanoyloxyhexadecanoyl)-6-0-hexadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-eicosanoyloxyhexadecanoyl)-6-0-octadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-eicosanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamlne
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-((3R)-3-eicosanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-S-((3R)-3-eicosanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-eicosanoyloxyhexadecanoyl)-6-0-tetradecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-eicosanoyloxyhexadecanoyl)-6-0-hexadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-eicosanoyloxyhexadecanoyl)-6-0-octadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-docosanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-((3R)-3-docosanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-docosanoyloxyhexadecanoyl)-6-0-dodecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-docosanoyloxyhexadecanoyl)-6-0-tetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-docosanoyloxyhexadecanoyl)-6-0-hexadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-docosanoyloxyhexadecanoyl)-6-0-octadecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-docosanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-((3R)-3-docosanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-docosanoyloxyhexadecanoyl)-6-0-dodecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-docosanoyloxyhexadecanoyl)-6-0-tetradecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-docosanoyloxyhexadecanoyl)-6-0-hexadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-docosanoyloxyhexadecanoyl)-6-0-octadecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-tetracosanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-((3R)-3-tetracosanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-0-((3R)-3-tetracosanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-tetracosanoyloxyhexadecanoyl)-6-0-tetradecanoyl-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-0-((3R)-3-tetracosanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-0-((3R)-3-tetracosanoyloxyhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-tetracosanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-((3R)-3-tetracosanoyloxyhexadecanoyl)-1-thio-β-D-gluco
pyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-dodecanoyl-1-S-((3R)-3-tetracosanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-tetracosanoyloxyhexadecanoyl)-6-0-tetradecanoyl-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-hexadecanoyl-1-S-((3R)-3-tetracosanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester and
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-S-((3R)-3-tetracosanoyloxyhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester.
[0017] The compounds of the present invention can be basically prepared by the following
process.
[0018] In the formulae, X is OH or SH; R₁ and R₂ are defined as above.
[0019] The above mentioned process consists of two acylation steps (the acylations at 6th
and lst positions of the glucopyranose moiety) and one deacetonation step.
[0020] The two acylation steps can be conducted by reacting a compound of the formula (II)
or (I′) with a specific acylating agent (R₂H, R₃H or its reactive derivative). These
steps are generally carried out in an anhydrous organic solvent (for example, dimethylformamide
or dioxane) and at room temperature or a slightly elevated temperature. When R₂H or
R₃H (a free acid) is used, it is conducted in the presence of an appropriate condensing
agent (for example, dicyclohexylcarbodiimide, N-cyclohexyl-N′-morpholinoethylcarbodiimide,
N-cyclohexyl-N′-(4-diethylaminocyclohexyl)-carbodiimide or N,N′-diethylcarbodiimide).
Examples of reactive derivatives of R₂H or R₃H are conventional reactive derivatives
used in acylation, such as mixed acid anhydrides, active esters, acid halides and
the like. The deacetonating step can be readily conducted under an acid hydrolysis
condition (e.g., using 80% acetic acid aqueous solution) at a slightly elevated temperature.
[0021] The compounds of the formula (II) are known or can be readily prepared by known methods.
[0022] The compounds obtained by the above process may be purified by a conventional method
such as a column chromatography using almina or silica gel, recrystallization and
the like.
[0023] The compounds of the formula (I) of the present invention have an action for enhancing
function of cells relevant to in vivo immune response and an action for increasing
the number of said cells, and hence they are useful as an immunoregulating agent.
The immunoregulating agent of the present invention can be used to enhance in vivo
activities of vaccines such as BCG vaccine, hepatitis vaccine, influenza virus vaccine
or the like, various antibacterial agents or anti-tumor agents.
[0024] The immunoregulating composition of the present invention comprises a compound of
the formula (I) and a pharmaceutically acceptable carrier. The composition may be
any dosage form for oral and parenteral administrations.
[0025] The compositions for oral administration are generally dosage forms such as powders,
tablets, emulsions,capsules, granules and liquid prepartions (including liquid extracts,
syrups and the like).
[0026] Examples of carriers for powders or other orally administrable solid preparations
include lactose, starch, dextrin, calcium phosphate, calcium carbonate, synthetic
or natural aluminium silicate, magnesium oxide, dried aluminium hydroxide, magnesium
stearate, sodium bicarbonate, dried yeast and the like, and those for liquid preparations
include water, glycerine, propylene glycol, simple syrup, ethanol, fatty oil, ethylene
glycol, polyethylene glycol, sorbitol and the like. A typical example of the composition
for parenteral administration is an injection. Liquid carriers for the injection include
sterile distilled water. When a compound of the formula (I) is less soluble in water,
an appropriate solubilizer is used. Each of the above preparations can be prepared
by conventional methods.
[0027] When the compounds of the formula (II) of the present invention are used for enhancement
of antitumor agents, they may be orally or parenterally administered to an adult human
in an amount of 150 to 250µg/day in one dose. When used for enhancement of vaccines,
they may be administered to an adult human in an amount of 0.5 to 2.0mg/1 to 2 weeks
in one dose. For treatment of hepatitis, they may be orally or parenterally administered
to an adult human 1 to 3 times for 3 months in an amount of 0.5 to 2.0mg in one dose.
For enhancement of antibacterial agents, they may be used to an adult human in an
amount 20 to 100µg/day in one dose.
[0028] The immunoregulating agents of the present invention may be generally used by formulating
themselves only as described above. But they may be formulated together with an agent
to be enhanced its action.
[0029] Further, the immunoregulating agents of the present invention can be used for not
only humans but also other mammals such as pigs, bovines, sheeps, dogs, and cats.
[0030] The present invention is illustrated with following examples.
Example 1
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-(2-tetradecylhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0031] The compound of the formula (III) wherein R₁ is 2-tetradecylhexadecanoyloxy group
(279.4mg, 0.281mmol) was dissolved in 80% acetic acid aqueous solution (8ml) and the
resultant was allowed to stand for 2 hours at 45°C. After confirming the completion
of the reaction with T.L.C.(CH₂Cl₂ : MeOH = 10 : 1), the resultant was concentrated
under reduced pressure to obtain quantitatively the title compound (266.2mg).
mp : 147.0-148.0°C
[α]
: +44.38°(c=1.050, CH₂Cl : MeOH=1 : 1)
IR γmax(KBr)cm⁻¹ : 3350, 2930, 2850, 1740, 1650, 1520
NMR(CD₃OD-CHCl₃)δ(ppm) : 0.88(t,6H,J=6.6Hz), 1.26(s,48H), 1.38-1.43(m,6H), 1.51-1.62(m,4H),
1.93(s,3H), 3.70(s,3H), 6.16(d,1H,J=4.0Hz)
Example 2
N-{2-0-[2-Acetamido-2,3-dideoxy-1-S-(2-tetradecylhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl]-D-lactoyl}-L-alanyl-D-isoglutamine
methylester
[0032] The compound of the formula (III) wherein R₁ is 2-tetradecylhexadecanoylthio group
(133.7mg) was dissolved in 80% acetic acid aqueous solution (15ml), which was allowed
to react for 2 hours at 45°C. After confirming the completion of the reaction with
T.L.C., the resultant was concentrated under reduced pressure and crystallized from
ether to obtain quantitatively the title compound (127.0mg, crystals).
mp : 130.0-131.0°C
[α]
: +46.79°(c=1,201, CH₂Cl₂ : MeOH=1 : 1)
IRγ max(KBr)cm⁻¹ : 3300, 2920, 2850, 1720, 1630, 1530
Example 3
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3- tetradecanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0033] The compound of the formula (III) wherein R₁ is 3-tetradecanoyloxytetradecanoyloxy
group (409.1mg, 0.411mmol) was dissolved in 80% acetic acid aqueous solution (15ml)
and allowed to stand for an hour at 45°C. In the same manner as that in Example 1,
the title compound was quantitatively obtained (386.9mg).
mp : 133.8-134.6°C
[α]
: +44.74° (c=1.180, CHCl₃ : MeOH=1 : 1)
IR γmax(KBr)cm⁻¹ : 3700-3140, 2930, 2850, 1740, 1250, 1630, 1540
NMR(CDCl₃)δ : 0.89(t,6H,J=2.2Hz), 1.27(m,36H), 1.43(m,6H), 1.60(m,4H), 2.00(s,3H),
2.10-2.30(m,4H), 2.44-2.67(m,6H), 3.68(s,3H), 5.31(m,1H), 6.05(d,1H)
Example 4
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-tetradecanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0034] The compound of the formula (III) wherein R₁ is 3-tetradecanoyloxytetradecanoylthio
group (580.1mg, 0.5808mmol) was dissolved in 80% acetic acid aqueous solution (12ml)
and allowed to stand for an hour at 45°C. After confirming the completion of the raction
with T.L.C. (CH₂Cl₂: MeOH=10 : 1), the resultant was concentrated under reduced pressure.
The resulting syrup was lyophilized to obtain quantitatively the title compound (555.2mg,
crystals).
mp : 110-111°C
[α]
: +26.68°(c=0.787, CH₂Cl₂ : MeOH=2 : 1)
IR γmax(KBr)cm⁻¹ : 3650-3130, 3300, 2940, 2860, 1740, 1650, 1550,
NMR(CDCl₃-CD₃OD)δ : 0.88 (t,6H,J=6.6Hz), 1.25 (m,36H), 1.35 (d,3H,J=7.0Hz), 1.39 (d,3H,J=7.3Hz),
1.43-1.58 (m,4H), 1.93(s,3H), 1.93-2.04 (m,2H), 2.09-2.87(m,6H), 3.71(s,3H), 4.05(t,1H,J=
10.4Hz), 4.28-4.33(m,1H), 4.31(q,1H,J=7.0Hz), 4.38-4.43 (m,1H), 5.12(d,1H,J=11.0Hz)
5.17-5.26(m,1H)
Example 5
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-(2-tetradecylhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0035] The compound of the formula (I) wherein R₁ is 2-tetradecylhexadecanoyloxy group (143.3mg,
0.150mmol) was dissolved in a mixture of dry dioxane (1.3ml) and dry N,N-dimethylformamide
(DMF, 1.3ml). To the solution were added decanoic acid (29.6mg, 0.180mmol), dicyclohexylcarbodiimide
(DCC, 61.7mg, 0.300mmol) and dimethylaminopyridine (DMAP, 9.1mg, 0.075mmol), and the
resultant was stirred for 14 hours at room temperature. After the completion of the
reaction, the reaction mixture was concentrated under reduced pressure. The resulting
syrup was subjected to a column chromatography [Wakogel® C-200 eluted with CH₂Cl₂/MeOH
((a) 150 : 1 and (b) 20 : 1)] and the eluate eluted with the eluent (b) was concentrated
under reduced pressure. The resultant syrup was subjected to a column chromatography
[active alumina 90 eluted with CH₂Cl₂/MeOH ((a′) 150 : 1 and (b′) 20 : 1)], to remove
DMAP and the eluate eluted with the eluent (b′) gave the title compound (121.3mg,
yield: 72.6%).
mp : 116.3-117.0°C
[α]
: +42.56°(C=0.726, CHCl₃ : MeOH=2 : 1)
IR γmax(KBr)cm⁻¹ : 3650-3150, 2940, 2870, 1740, 1650, 1540
NMR(CDCl₃)δ : 0.88(t,6H,J=6.8Hz), 0.92(t,3H,J=7.1Hz), 1.25(m,62H), 1.39(d,3H,J=6.6Hz),
1.41(d,3H,J=6.6Hz), 1.51-1.60(m,6H), 1.90-2.23(m,2H), 1.94(s,3H), 2.33(t,2H,J-7.5Hz),
2.39-2.50(m,3H), 3.69(s,3H), 6.18(d,1H,J=3.7Hz)
Example 6
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-tetradecanoyl-1-0-(2-tetradecylhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0036] The compound of the formula (I′) wherein R₁ is 2-tetradecylhexadecanoyloxy group
(139.7mg, 0.147mmol) is dissolved in a mixture of dry dioxane (2ml) and dry DMF (2ml).
To the solution were added tetradecanoic acid (40.0mg, 0.176mmol), DCC(60.2mg, 0.294mmol)
and DMAP(8.9mg, 0.074mmol). The resultant was stirred for 12 hours at room temperature
and then treated in the same manner as that in Example 5 to obtain the title compound
(105.4mg, yield: 61.7%).
mp : 116.8-117.7°C
[α]
: +29.22°(c=1.054, CH₂Cl₂)
IR γmax(KBr)cm⁻¹ : 3700-3100, 2940, 2860, 1740, 1660, 1540
NMR(CDCl₃)δ : 0.88(t,9H,J=6.4Hz), 1.25(m,7H), 1.38(d,3H, J=6.6Hz), 1.41(d,3H, J=7.3Hz),
1.49-1.60(m,6H), 1.93(s,3H), 2.03-2.21(m,2H), 2.32(t,2H,J=7.7Hz), 2.38-2.74(m,3H),
3.68(s,3H), 6.17(d,1H,J=3.7Hz)
Esample 7
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-0-(2-tetradecylhexadecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0037] The compound of the formula (I′) wherein R₁ is 2-tetradecylhexadecanoyloxy group
(122.7mg, 0.129mmol) was dissolved in a mixture of dry dioxane (1.5ml) and dry DMF(0.5ml).
To the solution were added octadecanoic acid (44.5mg, 0.155mmol), DCC(53.7mg, 0.258mmol)
and DMAP(7.9mg, 0.065mmol). The resultant was stirred for 14 hours and then treated
in the same manner as that in Example 5 to obtain the title compound(119.0mg, yield:
75.6%).
mp : 118.7-120.0°C
[α]
: +39.45°(c=0.621, CHCl₃ : MeOH=2 : 1)
IR γmax(KBr)cm⁻¹ : 3650-3150, 2930, 2860, 1740, 1650, 1540
NMR(CDCl₃)δ : 0.88(t,9H,J=6.6Hz), 1.25(m,78H), 1.39(d,3H,J=6.6Hz), 1.41(d,3H,J=6.6Hz),
1.49-1.60(m,6H), 1.94(s,3H), 1.90-2.26(m,2H), 2.32(t,2H,J=7.3Hz), 2.39-2.50(m,3H),
3.69(s,3H), 6.18(d,1H,J=3.7Hz)
Example 8
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-(2-tetradecylhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0038] The compound of the formula (I′) wherein R₁ is 2-tetradecylhexadecanoylthio (128.4mg,
0.134mmol) was dissolved in a mixture of dry dioxane (1.5ml) and dry DMF (1.0ml).
To the solution were added decanoic acid (27.4mg, 0.161mmol), DCC(54.6mg, 0.268mmol)
and DMAP(8.1mg, 0.067mmol). The resultant was stirred for 6.5 hours at room temperature.
After confirming the completion of the reaciton with T.L.C. (10 : 1), the resultant
was lyophilized and subjected to a column chromatography [Wakogel® C-200 eluted with
CH₂Cl₂/MeOH ((a) 150 : 1 and (b) 50 : 1)]. The eluate eluted with the eluent (b) gave
the title compound (99.6mg, yield: 66.8%).
mp : 98.6-99.4°C
[α]
: +17.69°(c=0.797, CH₂Cl₂: MeOH=2 : 1)
IR γmax(KBr)cm⁻¹ : 3500-3200, 2950, 2880, 1750, 1640, 1560
NMR(CDCl₃-CD₃OD)δ : 0.88(t,6H,J=6.6Hz), 0.92(t,3H,J=7.1Hz), 1.25(m,56H), 1.34(d,3H,J=6.6Hz),
1.40(d,3H,J=7.0Hz), 1.58-1.71(m,6H), 1.90(s,3H), 1.94-2.24(m,2H), 2.33(t,2H,J=7.5Hz),
2.42-2.52(m,3H), 3.69(s,3H), 5.11(d,1H,J=10.6Hz)
Example 9
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-tetradecanoyl-1-S-(2-tetradcylhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0039] The compound of the formula (I′) wherein R₁ is 2-tetradecylhexadecanoylthio group
(125.0mg, 0.131mmol) was dissolved in a mixture of dry dioxane (1.5ml) and dry DMF
(1.0ml). To the solution were added tetradecanoic acid (35.3mg, 0.157mmol), DCC(53.1mg,
0.262mmol) and DMAP (7.9mg, 0.066mmol). The resultant was stirred for 3 hours at room
temperature and then treated in the same manner as that in Example 8 to obtain the
title compound (125.8mg, yield: 82.5%).
mp : 99.0-100.4°C
[α]
: +2.13°(c=2.16, CH₂Cl₂)
IR γmax(KBr)cm⁻¹ : 3650-3200, 2930, 2860, 1740, 1650, 1550
NMR(CDCl₃)δ : 0.85-0.95(m,9H), 1.25(m,68H), 1.36(d,3H,J=6.6Hz), 1.41(d,3H,J=7.3Hz),
1.47-1.76(m,6H), 1.88-2.32(m,2H), 1.94(s,3H), 2.35(t,2H,J=7.9Hz), 2.47-2.53(m,3H),
3.70(s,3H), 5.12(d,1H,J=10.3Hz)
Example 10
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-S-(2-tetradecylhexadecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0040] The compound of the formula (I′) wherein R₁ is 2-tetradecylhexadecanoylthio (122.4mg,
0.128mmol) was dissolved in a mixture of dry dioxane (1.5ml) and dry DMF (1.0ml).
To the solution were added octadecanoic acid (43.0mg, 0.145mmol), DCC(52.0mg, 0.245mmol)
and DMAP (7.7mg, 0.064mmol). The resultant was stirred for 4 hours at room temperature
and treated in the same manner as that in Example 8 to obtain the title compound (102.7mg,
yield : 65.6%).
mp : 99.3-101.0°C
[α]
: +2.06° (c=0.376, CH₂Cl₂ MeOH=2 : 1)
IR γmax(KBr)cm⁻¹ : 3600-3150, 2920, 2840, 1740, 1640, 1540
NMR(CDCl₃-CD₃OD)δ : 0.88(t,9H,J=6.6Hz), 1.26(m,76H), 1.35(d,3H,J=6.6Hz), 1.40(d,3H,J=7.3Hz),
1.58-1.61(m,6H), 1.88(s,3H), 1.92-2.26(m,2H), 2.33(t,2H,J=7.7Hz), 2.41-2.55(m,3H),
3.69(s,3H), 4.40(q,1H), 5.10(d,1H,J=11.0Hz)
Example 11
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-0-((3R)-3-tetradecanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0041] The compound of the formula (I′) wherein R₁ is 3-tetradecanoyloxytetradecanoyloxy
group (116.9mg, 0.121mmol) was dissolved in a mixture of dioxane (1.5ml) and dry DMF
(0.5ml). To the solution were added decanoic acid (24.3mg, 0.145mmol), DCC (48.4mg,
0.242mmol) and DMAP (7.2mg, 0.161mmol). The resultant was stirred for 8 hours at room
temeperature. After confirming, the completion of the reaction with T.L.C. (CH₂Cl₂
MeOH=10 : 1), the resultant was concentrated under reduced pressure. The resulting
syrup was subjected to a column chromatography [Wakogel® C-200 eluted with CH₂Cl₂/MeOH
((a) 150 : 1 and (b) 35 : 1)]. The eluate eluted with the eluent (b) gave the title
compound (80.4mg, yield : 59.6%).
mp : 72.0-72.8°C
[α]
: +27.86°(c=0.804, CH₂Cl₂)
IR γmax(Film)cm⁻¹ : 3700-3100, 2930, 2850, 1740, 1650, 1540
NMR(CDCl₃)δ : 0.88(t,9H,J=6.6Hz), 1.25-1.27(m,48H), 1.43(d,3H, J=6.6Hz), 1.45(d,3H,J=7.0Hz),
1.61(m,6H), 2.00(s,3H), 2.04-2.24(m,2H), 2.30(t,2H, J=7.5Hz), 2.32-2.67(m,6H), 3.69(s,3H),
4.21(q,1H,J=6.6Hz), 5.29(m,1H), 6.05(d,1H,J=3.3Hz)
Example 12
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-tetradecanoyl-1-0-((3R)-3-tetradecanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester.
[0042] The compound of the formula (I′) wherein R₁ is 3-tetradecanoyloxytetradecanoyloxy
(108.6mg, 0.115mmol) was dissolved in a mixture of dry dioxane (1.5ml) and dry DMF
(0.5ml). To the solution were added tetradecanoic acid (30.1mg, 0.137mmol), DCC(45.3mg,
0.228mmol) and DMAP (6.7mg, 0.057mmol). The mixture was allowed to react for 14 hours
at room temperature. The resultant was treated in the same manner as that in Example
11 to obtain the title compound (99.1mg, yield: 74.6%).
mp : 72.5-73.6°C
[α]
: +26.51°(c=1.388,CH₂Cl₂)
IR γmax(film)cm⁻¹ : 3700-3150, 2930, 2850, 1740, 1660, 1540
NMR(CDCl₃)δ : 0.88(t,9H,J=6.6Hz), 1.25-1.38(m,56H), 1.43(d,3H,J=6.6Hz), 1.45(d,3H,J=7.0Hz),
1.60(m,6H), 1.99(s,3H), 2.06-2.24(m,2H), 2.30(t,2H,J=7.5Hz), 2.32-2.66(m,6H), 3.69(s,3H),
4.21(q,1H,J=7.0Hz), 5.30(m,1H), 6.05(d,1H,J=3.3Hz)
Example 13
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-0-((3R)-3-tetradecanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0043] The compound of the formula (I′) wherein R₁ is 3-tetradecanoyloxytetradecanoyl group
(108.8mg, 0.114mmol) was dissolved in a mixture of dry dioxane (1.5ml) and dry DMF
(0.5ml). To the solution were added octadecanoic acid (37.6mg, 0.137mmol), DCC (45.4mg,
0.228mmol) and DMAP (6.7mg, 0.057mmol). The resultant was stirred for 14 hours at
room temperature and then treated in the same manner as that in Example 11 to obtain
the title compound (95.6mg, yield: 68.5%).
mp : 68.1-69.0°C
[α]
: +26.15°(c=1.338, CH₂Cl₂)
IR γmax(film)cm⁻¹ : 3700-3150, 2930, 2850, 1740, 1650, 1540
NMR(CDCl₃)δ : 0.88(t,9H,J=6.6Hz), 1.25-1.39(m,64H), 1.43(d,3H,J=6.6Hz), 1.44(d,3H,J=7.0Hz),
1.58-1.60(m,6H), 1.99(s,3H), 2.02-2.22(m,2H), 2.30(t,2H,J=7.5Hz), 2.32-2.67(m,6H),
3.69(s,3H), 4.21(q,1H,J=6.6Hz), 5.30(m,1H), 6.05(d,1H,J=3.3Hz)
Example 14
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-decanoyl-1-S-((3R)-R-tetradecanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0045] The compound of the formula (I) wherein R₁ is 3-tetradecanoyloxytetradecanoylthio
(239.2mg, 0.250mmol) was dissolved in a mixture of dry dioxane (0.5ml) and dry DMF
(0.5ml). To the solution were added decanoic acid (51.6ml, 0.300mmol), DCC (102.9mg,
0.50mmol) and DMAP (15.2mg, 0.499mmol), and the resultant was stirred for 2 hours
at room temperature. After confirming the completion of the reaction with T.L.C. (CH₂Cl₂
MeOH=10 : 1), DC urea of a reaction by-product was filtered off and washed with dioxane.
The filtrate and washings were combined and then lyophilized. The amorphous material
thus obtained was subjected to a column chromatography [Wakogel® C-200 eluted with
CH₂Cl₂/MeOH ((a) 200 : 1, (b) 70 : 1, (c) 60 : 1 and (d) 40 : 1)]. The eluate eluted
with the eluent (c) gave the title compound (111.6mg, yield: 40.2%).
mp : 138.6 - 139.9°C
[α]
: +17.09° (c=0.702, CH₂Cl₂ : MeOH = 2:1)
IRγmax(film)cm⁻¹ : 3650-3020, 3250, 2930, 2850, 1740, 1660, 1540
NMR(CDCl₃)δ: 0.87(t,9H,J=5.7Hz), 1.25(m,52H), 1.39(d,3H,J=6.6Hz), 1.58(m,6H), 1.95(s,3H),
2.10-2.28(m,2H), 2.34(6,2H,J=7.7Hz), 2.47-2.91(m,6H), 3.69(s,3H), 5.13(d,1H,J=11.0Hz),
5.11-5.21(m,1H)
Example 15
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-tetradecanoyl-1-S-((3R)-3-tetradecanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0046] The compound of the formula (I′) wherein R₁ is 3-tetradecanoyloxytetradecanoylthio
(206.5mg, 0.215 mmol) was dissolved in dry dioxane (0.5ml) and dry DMF (0.5ml). To
the solution were added tetradecanoic acid (59.0mg, 0.259 mmol), DCC (88.9mg, 0.431
mmol) and DMAP (13.1mg, 9.1077 mmol). The resultant was stirred for 2.5 hours at room
temperature and then treated in the same manner as that in Example 14 to obtain the
title compound (95.6mg, yield: 38.0%).
mp : 136.1 - 137.7°C
[α]
: +17.57°(c=0.956, CH₂Cl₂:MeOH = 2:1)
IR γmax (film)cm⁻¹: 3650-3120, 3300, 2930, 2860, 1740, 1640, 1540
NMR(CDCl₃)δ: 0.88(t,9H,J=6.6Hz), 1.25(m,56H), 1.39(d,3H,J=7.0Hz), 1.42(d,3H,J=7.0Hz),
1.57(m,6H), 1.97(s,3H), 2.01-2.28(m,2H), 2.34(t,2H,J=7.7Hz), 3.71(s,3H), 5.13(d,1H,J=11.0Hz),
5.11-5.23(m,1H)
Example 16
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-S-((3R)-3-tetradecanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0047] The compound of the formula (I′) wherein R₁ is 3-tetradecanoyloxytetradecanoylthio
(203.2mg, 0.212 mmol) was dissolved in a mixture of dry dioxane (0.5ml) and dry DMF
(0.5ml). To the solution were added octadecanoic acid (63.1mg, 0.254 mmol), DCC (87.5mg,
0.424 mmol) and DMAP (12.9mg, 0.106 mmol). The resultant was stirred for 3 hours at
room temperature and then treated in the same manner as that in Example 14 to obtain
the title compound (112.2mg, yield: 43.2%).
mp : 133.7 - 134.5°C
[α]
: +17.46° (c=1.122, CH₂Cl₂:MeOH = 2:1)
IR γmax(film)cm⁻¹ : 3700-3150, 3320, 2960, 2900, 1750, 1680, 1580
NMR(CDCl₃)δ: 0.87(6,9H,J=5.5Hz), 1.25(m,6.6H), 1.39(d,3H,J=5.9Hz), 1.57(m,6H), 1.95(s,3H),
1.95-2.18(m,2H), 2.25-2.90(m,6H), 2.38(t,2H,J=7.1Hz), 3.69(s,3H), 5.13(d,1H,J=11.0Hz),
5.11-5.20(m,1H)
Example 17
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-hexadecanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0048] The compound of the formula (III) wherein R₁ is 3-hexadecanoyloxytetradecanoyloxy
(408.1mg, 0.410 mmol) was dissolved in 80% acetic acid aqueous solution (15ml), which
was allowed to stand for 1.5 hours at 45°C. In the same manner as that in Example
4, the title compound (391.7mg) was quantitatively obtained from the above solution.
m.p. : 134.2 - 135.5°C
[α]
: +47.38° (c=0.878, CH₂Cl₂:MeOH = 1:1)
IR γmax (cm)⁻¹ : 3700-3100(OH), 3300(NH) 2920, 2850(CH) 1740(ester) 1650, 1530(amido)
NMR(CDCl₃)δ : 0.88(t,9H,JMeCH₂6Hz,3MeCH₂), 1.25(m,40H,20CHz), 1.42(d,3H,J
MeCH7.3Hz,MeC of Ala), 1.45(d,3H,J
MeCH7.3Hz,HeC of Lac), 1.57-1.60(m,6H,3MeCh₂), 1.95-2.17(m,2H,CH₂CH of Gln), 2.00(S,3H,AcN),
2.30(t,2H,JCH₂CH₂7.5Hz,CH₂CO of Gln), 2.37-2.66(m,6H,3CH₂CO), 3.68(S,3H,COOMe), 5.30-5.42(m,1H,H-3
of C₁₇-O-C₁₆), 6.03(d,1H,J
1.2,3.3Hz,H-1),
Example 18
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-0-((3R)-3-hexadecanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0049] The compound of the formula (I′) wherein R₁ is 3-hexadecanoyloxytetradecanoyloxy
(191.1mg, 0.200mmol) was dissolved in a mixture of dry dioxane (3.0ml) and dry DMF
(1.0ml). To the solution were added octadecanoic acid (74.0mg, 0.260mmol), DDC(82.5mg,
0.400mmol) and DMAP (12.2mg, 0.100mmol). The resultant was stirred for 16 hours at
room temperature. In the same manner as that in Example 11, the title compound (193.1mg,
yield : 78.9%) was obtained.
mp : 69.5-71.0°C
[α]
: +40.69°(C=1.504, CH₂Cl₂ : MeOH=2 : 1)
IR γmax(cm⁻¹): 3700-3130(OH), 3300(NH), 2930, 2860(CH), 1740(ester), 1660, 1540(amido),
NMR(CDCl₃) : 0.88(t,9H,JMeCH₂6.6Hz,3MeCH₂), 1.25(m,68H,34CH₂), 1.43(d,3H,JMeCH5.9Hz,MeC
of Ala), 1.45(d,3H,JMeCH5.9Hz,MeC of Lac), 1.60(m,6H,3MeCH₂), 1.99(s,3H,AcN), 2.19-2.66(m,8H,CH₂CH
of Gln,3CH₂CO), 2.35(t,2H,JCH₂CH₂7.7Hz,CH₂CO of Gln), 3.69(s,3H,COOMe), 5.30(m,1H,H-3
of C₁₄OC₁₆), 6.05(d,1H,J
1.2, 2.9Hz,H-1)
Example 19
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-hexadecaonyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0050] The compound of the formula (III) wherein R₁ is 3-hexadecanoyloxytetradecanoylthio
(586.6mg, 0.580mmol) was dissolved in 80% acetic acid aqueous solution (12ml), which
was allowed to stand for an hour at 45°C. In the same manner as that in Example 4,
the title compound (563.4mg) was quantitatively obtained.
mp : 94.6-95.8°C
[α]
: +28 06(C=1.112, CH₂Cl₂. : MeOH=1 : 1)
IR γmax(cm⁻¹) : 3680-3130(OH), 3300(NH), 2940, 2870(CH), 1740(ester), 1650, 1550(amido)
NMR(CDCl₃) : 0.88(t,6H,JMeCH₂6.4Hz,2MeCH₂), 1.27(m,40H,20CH₂), 1.37(d,3H,JMeCH7.0Hz,MeC
of Lac), 1.41(d,3H,JMeCH7.0Hz,MeC of Ala), 1.60(m,4H,2MeCH₂), 1.91(s,3H,AcN), 1.91-2.02(m,1H,CHCH₂
of Gln), 2.21-2.90(m,6H,CH₂CO of Gln,2CH₂CO), 3.70(s,3H,COOMe), 4.05(t,1H,J
6a,6b,10.3Hz,H-6a), 4.22-4.26(m,2H,CH of Lac and Ala), 4.34-4.39(m,1H,CH of Gln), 5.13(d,1H,J
1.210.6Hz,H-1), 5.21-5.25(m,1H,H-3 of C₁₄OC₁₆)
Example 20
N-[2-0-{2-Acetamldo-2,3-dideoxy-6-0-octadecanoyl-1-S-((3R)-3-hexadecanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0051] The compound of the formula (I′) wherein R₁ is 3-hexadecanoyloxytetradecanoylthio(340.0mg,
0.350mmol) was dissolved in a mixture of dry dioxane (4.0ml) and dry DMF(1.5ml). To
the solution were added octadecanoic acid(129.4mg, 0.455mmol), DCC(144.4mg, 0.700mmol)
and DMAP(21.4mg, 0.175mmol). The resultant was stirred for 3 hours at room temperature.
In the same manner as that in Example 14, the title compound (203.1mg, yield : 46.8%)
was obtained.
mp : 171.2-172.8°C
[α]
: +17.01°(C=0.723, CH₂Cl₂ : MeOH=2 : 1)
IR γmax(cm⁻¹) : 3320, 3270(NH, OH), 2920, 2850(CH), 1740(ester), 1650, 1540(amido)
NMR(CDCl₃) : 0.87(t,9H,JMeCH5.3Hz,3MeCH₂), 1.25(m,70H,35CH₂), 1.39(d,3H,JMeCH6.6Hz,MeC
of Ala), 1.58(m,6H,3MeCH₂), 1.94(s,3H,AcN), 2.22-2.91(m,2H,CH₂CO of Gln), 2.32(t,2H,JCH₂CH₂7.7Hz,CH₂CO
of Gln), 3.69(s,3H,COOMe), 5.13(d,1H,J
1.211.0Hz,H-1), 5.11-5.20(m,1H,H-3 of C₁₄-O-C₁₆)
Example 21
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-octadecanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0052] The compound of the formula (III) wherein R₁ is 3-octadecanoyloxytetradecanoyloxy(388.9mg,
0.380mmol) was dissolved in 80% acetic acid aqueous solution(15ml), which was allowed
to stand for 2 hours at 45°C. In the same manner as that in Example 4, the title compound
(373.7mg) was quantitatively obtained(373.7mg).
mp : 187-188.5°C
[α]
: +47.11°(C=0.900, CH₂Cl₂ : MeOH=1 : 1)
IR γmax(cm⁻¹) : 3700-3100(OH), 3300(NH), 2910, 2850(CH), 1740(ester), 1650, 1540(amido)
NMR(CDCl₃) : 0.88(t,9H,JMe₁CH₂7.0Hz,3MeCH₂), 1.25(m,44H,22CH₂), 1.41(d,3H,JMeCH7.8Hz,MeC
of Ala), 1.44(d,3H,JMeCH7.8Hz,MeC of Lac), 1.99(s,3H,AcN), 1.94-2.04(m,2H,CH₂CH of
Gln), 2.30(t,2H,JCH₂CH₂8.0
z,CH₂CO of Gln), 2.27-2.46(m,6H,3CH₂CO), 3.70(s,3H,COOMe), 5.30(m,1H,H-3 of C₁₄OC₁₈),
6.05(d,1H,J₁₂7.8Hz,H-1)
Example 22
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-0-((3R)-3-octadecanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0053] The compound of the formula (I′) wherein R₁ is 3-octadecanoyloxytetradecanoyloxy(177,0mg,
0.18mmol) was in a mixture of dry dioxane(3.0ml) and dry DMF(1.0ml). To the solution
were added octadecanoic acid(66.6mg, 0.234mmol), DCC(74.3mg, 0.360mmol) and DMAP(11.0mg,
0.090mmol). The resultant was stirred for 16 hours at room temperature. In the same
manner as that in Example 11, the title compound (164.0mg, 72.8%) was obtained.
mp : 106-108.5°C
[α]
: +38.46°(C=0.624, CH₂Cl₂ : MeOH=1 : 1)
IR γmax(cm⁻¹) : 3700-3150(H), 3300(NH), 2930, 2860(CH), 1740(ester), 1660, 1540(amido)
NMR(CDCl₃) : 0.88(t,9H,JCH₂CH₂66Hz,3MeCH₂), 1.25(m,72H,36CH₂), 1.43(d,3H,JMeCH6.2Hz,MeC
of Lac), 1.59(m,6H,3MeCH₂), 1.99(s,3H,AcN), 2.01-2.20(m,8H,CH₂CH of Gln,3CH₂CO), 2.30(t,2H,JCH₂CH₂7.7Hz,CH₂CO
of Gln), 3.69(s,3H,COOMe), 5.30(m,1H,H-3 of C₁₄OC₁₈), 6.05(d,1H,J
1.23.0Hz,H-1)
Example 23
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-octadecanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0054] The compound of the formula (III) wherein R₁ is 3-octadecanoyloxytetradecanoylthio(634.1mg,
0.610mmol) was dissolved in 80% acetic acid acqueous solution(15ml), which was allowed
to stand for an hour at 45°C. In the same manner as that in Example 4, the title compound
(609.6mg) was quantitatively obtained.
mp : 112.5-113.8°C
[α]
: +24.62°(C=0.600, Ch₂Cl₂ : MeOH=1 : 1)
IR γmax(cm⁻¹) : 3400-3100(OH), 3260(NH), 2910, 2850(CH), 1740(ester), 1640, 1530(amido)
NMR(CDCl₃) : 0.88(t,6H,JMeCH₂,4.0Hz,2MeCH₂), 1.25(m,44H,22CH₂), 1.33(d,3H,JMeCH7.3Hz,MeC
of Lac), 1.36(d,3H,JMeCH7.3Hz,MeC of Ala), 1.58(m,4H,2MeCH₂), 1.92(s,3H,AcN), 1.91-2.04(m,2H,CHCH₂
of Gln), 2.26(m,6H,CH₂CO of Gln,2CH₂CO), 3.69(s,3H,COOMe), 4.02-4.09(t,1H,J
6a,6b8.7Hz,H-6a), 4.28(m,1H,CH of Gln), 5.08(d,1H,J
1.24.0Hz,H-1), 5.21(m,1H,H-3 of C₁₄-O-C₁₈)
Example 24
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl- 1-S-((3R)-3-octadecanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0055] The compound of the formula (I′) wherein R₁ is 3-octadecanoyloxytetradecanoylthio(400.0mg,
0.400mmol) was dissolved in a mixture of dry dioxane (4.0ml) and dry DMF(1.5ml). To
the solution were added octadecanoic acid(147.9mg, 0.520mmol), DCC(165.1mg, 0.800mmol)
and DMAP(24.4mg, 0.200mmol), and the resultant was stirred for 3.5 hours at room temperature.
In the same manner as that in Example 14, the title compound (258.6mg, yield : 51.0%)
was obtained.
mp : 123.1-124.5°C
[α]
: +17.01°(C=0.723, CH₂Cl₂ : MeOH=2 : 1)
IR γmax(cm⁻¹) : 3650-3150(OH), 3300(NH), 2930, 2850(CH), 1730(ester), 1650, 1550(amido)
NMR(CDCl₃) : 0.88(t,9H,JMeCH₂5.5Hz,3MeCH₂), 1.25(m,74H,37CH₂), 1.34(d,3H,JMeCH6.6Hz,MeC
of Ala), 1.44-1.67(m,6H,3MeCH₂), 1.85(s,3H,AcN), 2.17-2.79(m,2H,CH₂CHof Gln), 2.31(t,2H,JCHh₂CH₂8.4Hz,CH₂CO
of Gln), 3.70(s,3H,COOMe), 5.10(d,1H,J
1.210.6Hz,H-1), 5.14(m,1H,H-3 of C₁₄OC₁₈)
Example 25
N-[2-0-{2-Acetamido-2,3-dideoxy-1-0-((3R)-3-tetracosanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0056] The compound of the formula (III) wherein R₁ is 3-tetracosanoyloxytetradecanoyloxy(465.2mg,
0.420mmol) was dissolved in 80% acetic acid aqueous solution (15ml), which was allowed
to stand for an hour at 45°C. In the same manner as that in Example 4, the title compound(448.3mg)
was quantitatively obtained.
mp : 183.5-185°C
[α]
: +34.13° (C=0.920, CH₂Cl₂ : MeOH=2 : 1)
IR γmax(cm⁻¹) : 3700-3120(OH), 3300(NH), 2930, 2850(CH), 1740(ester), 1660, 1540(amido)
NMR(CDCl₃) : 0.89(t,9H,JMeCH₂6.6Hz,3MeCH₂), 1.25(m,56H,28CH₂), 1.41(d,3H,JMeCH6.9Hz,MeC
of Ala), 1.44(d,3H,JMeCH6.9Hz,MeC of Lac), 1.60(m,6H,3MeCH₂), 1.99(s,3H,AcN), 1.94-2.01(m,2H,CH₂CHof
Gln), 2.20-2.39(m,6H,3CH₂CO), 2.29(t,2H,JCH₂CH₂13Hz,CH₂OO of Gln), 3.69(s,3H,COOMe),
5.30(m,1H,H-3 of C₁₄OC₂₄), 6.05(d,1H,J
1.22.9Hz,H-1)
Example 26
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-0-((3R)-3-tetracosanoyloxytetradecanoyl)-α-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0057] The compound of the formula (I′) wherein R₁ is 3-tetracosanoyloxytetradecanoyloxy
(234.8mg, 0.220mmol) was dissolved in a mixture of dry dioxane (3.0ml) and dry DMF(1.0ml).
To the solution were added octadecanoic acid (81.3mg, 0.286mmol), DCC (90.8mg, 0.440mmol)
and DMAP(13.4mg, 0.110mmol), and the resultant was stirred for 12 hours at room temperature.
In the same manner as that in Example 11, the title compound (200.7mg, yield : 68.3%)
was obtained.
mp : 66.5-68°C
[α]
: +34.11° (c=0.680, CH₂Cl₂ : MeOH=1 : 1)
IR γmax(cm⁻¹) : 3700-3100(OH), 3300(NH), 2930, 2850(CH), 1760(ester), 1660, 1540(amido)
NMR(CDCl₃) : 0.88(t,9H,JCH₂CH₂6.6Hz,3MeCH₂), 1.25(m,88H,44CH₂), 1.43(d,3H,JMeOH6.6Hz,MeC
of Ala), 1.44(d,3H,JMeOH7.0Hz,MeC of Lac), 1.61(m,6H,3MeCH₂), 2.00(m,8H,CH₂CH of Gln,3CH₂CO),
1.99(s,3H,AcN), 2.33(t,2H,JCH₂CH₂4.2Hz,CH₂CO of Gln). 3.65(s,3H,COOMe), 4.20(q,1H,JMe₁CH,Hz,MeCH
of Ala), 5.29(m,1H,H-3 of C₁₄OC₂₄), 6.04(d,1H,J
1.233Hz,1-H)
Example 27
N-[2-0-{2-Acetamido-2,3-dideoxy-1-S-((3R)-3-tetracosanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0059] The compound of the formula (III) wherein R₁ is 3-tetracosanoyloxytetradecanoylthio
(617.9mg, 0.550mmol) was dissolved in 80% acetic acid aqueous solution (12ml), which
was allowed to stand for an hour at 45°C. In the same manner as that in Example 4,
the title compound (595.9mg) was quantitatively obtained.
mp : 168.5-170.1°C
[α]
: +5.18° ( C=0.772, CH₂Cl₂ MeOH=1 : 1)
IR γmax(cm⁻¹) : 3500-3200(OH), 3280(NH), 2910, 2850(CH), 1720(ester), 1630, 1540(amido)
NMR(CDCl₃) : 0.88(t,6H,JMe₁CH₂ Hz,2MeCH₂) 1.25(m,56H,28CH₂), 1.30(d,3H,JMeCH8.3Hz,MeC
of Lac), 1.34(d,3H,JMeCH7.5Hz,MeC of Ala), 1.58(m,4H,2MeCH₂), 1.97-1.91(m,2H,2MeCH₂),
1.94(s,3H,AcN), 2.25(m,6H,CHCH₂ of Gln), 3.69(s,3H,COOMe), 4.05(t,1H,J
6a,6b10.1Hz,H-6a), 4.24-4.28(m,1H,CH of Gln), 5.09(d,1H,J
1.210.8Hz,H-1), 5.13-5.19(m,1H,H-3 of C₁₄-O-C₂₄)
Example 28
N-[2-0-{2-Acetamido-2,3-dideoxy-6-0-octadecanoyl-1-S-((3R)-3-tetracosanoyloxytetradecanoyl)-1-thio-β-D-glucopyranos-3-yl}-D-lactoyl]-L-alanyl-D-isoglutamine
methylester
[0060] The compound of the formula (I′) wherien R₁ is 3-tetracosanoyloxytetradecanoylthio
(411.8mg, 0.380mmol) was dissolved in a mixture of dry dioxane (4.0ml) and dry DMF
(1.5ml). To the solution were added octadeconoic acid (140.5mg, 0.494mmol), DCC(156.8mg,
0.760mmol) and DMAP (23.2mg, 0.190mmol), and the resultant was stirred for 3 hours
at room temperature. In the same manner as that in Example 14, the title compound
(223.5mg, yield:43.5%) was obtained. mp : 147.5-149.0°C
[α]
: +17.40° ( C=0.632,CH₂Cl₂ MeOH=1 : 1)
IR γmax(cm⁻¹) : 3600-3200(OH), 3300(NH), 2950, 2880(CH), 1750(ester), 1660, 1560(amido)
NMR(CDCl₃) : 0.88(t,9H,JMeCH5.5Hz,3MeCH₂), 1.25(m,86H,43CH₂), 1.35(d,3H,JMeCH6.3Hz,MeC
of Ala), 1.57(m,6H,3MeCH₂), 1.90(s,3H,AcN), 2.05-2.90(m,2H,CH₂CH of Gln), 2.35(t,2H,JCH₂CH₂7.8Hz,CH₂CO
of Gln), 3.68(s,3H,COOMe), 5.13(d,1H,J
1.211.0Hz,H-1), 5.15(m,1H,H-3 of C₁₄OC₂₄)
[0061] Pharmacological activities of the compounds of the present invention are shown as
follows.
(1) Hepatitis-vaccine enhancing activity (adjuvant activity)
[0062] A compound of the present invneiton was dissolved in lipidmicrosphere (1mg/ml). On
the other hand, a solution of hepatitis B virus surface antigen (HBs) in physiological
saline was prepared (50µg/ml). The above solutions in equal amounts were mixed to
prepare a test solution. A control solution was prepared by the exclusion of the compound
of the present invention from said test solution. A mixture of a suspension of aluminium
hydroxide gel in physiological saline (1mg/ml) and said hepatitis vaccine preparation
in equal amounts was prepared as another control solution. The test solution (0.2ml)
was intraperitoneally administered to each mouse in one group consisting of seven
female CDF₁ mice.
[0063] Blood samples were collected from the fundus ocluli vein of each mouse every week
after the administration and then centrifuged to obtain serums. Three weeks after
the administration, 0.2ml of the test liquid was intraperitoneally administered again
to each mouse for secondary stimulation. Then blood collecting was conducted every
week to obtain serums after the application of the secondary stimulation, in the same
manner as that described above.
[0064] The amount of the IgG antibodies against the hepatitis B virus surface antigens (HBs)
in the serums thus obtained was determined with an ELISA method. The results are shown
in Table 1.
(2) Influenza HA vaccine enhancing activity (adjuvant activity)
[0065] A compound of the present invention was dissolved in lipidmicrosphere (1mg/ml). On
the other hand, a solution of influenza HA vaccine (B/nagasaki/1/87 strain) in physiological
saline was prepared (100 ccA/ml). The above solutions in equal amounts were mixed
to prepare a test solution. A control solution was made by the exclusion of the compound
of the present inveniton from said test liquid. A mixture of a suspension of aluminium
hydroxide gel in physiological saline(1mg/ml) and said influenza HA vaccine preparation
in equal amounts was prepared as another control liquid. The test solution (0.2ml)
was intraperitoneally administered to each mouse in one group consisting of seven
female CDF₁ mice.
[0066] Blood samples were collected from the fundus oculi vein of each mouse every week
after the administration and then centrifuged to obtain serums. Three weeks after
the aministration, 0.2ml of the test liquid was intraperitoneally administered again
to each mouse for secondary stimulation. Then, blood collecting was conducted every
week to obtain serums after the application of the secondary stimulation, in the same
manner as that described above.
[0067] The amount of the IgG antibodies against the influenza HA vaccine (B/Nagasaki/1/87
strain) in the serums thus obtained was determined with an ELISA mehtod. The results
are shown in Table 2.
(3) Activation of macrophages (an effect which inhibits the growth of tumor cells)
[0068] A compound of the present invention was dissolved in lipidmicrosphere to obtain a
solution in a concentration of 500µg/ml, and 0.2ml of such solution was intraperitoneally
administered to each mouse in one group consisting of seven female CDF₁ mice. Intraperitoneal
macrophages obtained three days after the administration and L-1210 mouse leukemia
cells were mixed in the ratio of cell numbers of 20 : 1, respectively. Two hundred
µl of the mixture was placed in each well of one sheet of 96 well microtiter plate.
After 72 hours, the increase of the cell number in each well was determined by a MTT
assay method. The ratio of the cell number for the mixture of the L-1210 cells and
the macrophage relative to the cell number for the L-1210 cells only(growth inhibitory
ratio) was determined, and the results are shown in Table 3.
Table 3
Test material |
Growth inhibitory ratio of L-1210 mouse leukemia cells(%) |
Example 1 |
40.0 |
2 |
41.3 |
3 |
42.6 |
4 |
45.2 |
5 |
57.8 |
6 |
63.0 |
7 |
90.2 |
8 |
57.9 |
9 |
58.5 |
10 |
76.6 |
11 |
59.7 |
12 |
79.0 |
13 |
39.7 |
14 |
96.4 |
15 |
87.5 |
16 |
76.3 |
Control |
9.1 |