(19)

(11)

EP 1 077 682 A2

(12)

(88) Date of publication A3: 17.02.2000 (43) Date of publication: 28.02.2001 Bulletin 2001/09 (21) Application number: 99922302.7 (22) Date of filing: 13.05.1999

(51) International Patent Classification (IPC)7: A61K 9/20, A61K 31/445 (86) International application number: PCT/GB9901/520 (87) International publication number: WO 9958/113 (18.11.1999 Gazette 1999/46)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: RO SI (30) Priority: 13.05.1998 GB 9810181 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford,Middlesex TW8 9EP (GB)	(72) Inventors: ELDER, David Philip,SmithKline Beecham Pharm. Harlow,Essex CM19 5AW (GB) LEONARD, Graham Stanley,SmithKline Beecham Pharm. Harlow,Essex CM19 5AW (GB) (74) Representative: West, Vivien  SmithKline Beecham plcCorporate Intellectual Property,Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)