(19)

(11)

EP 1 089 794 A2

(12)

(88) Date of publication A3: 04.01.2001 (43) Date of publication: 11.04.2001 Bulletin 2001/15 (21) Application number: 99935376.6 (22) Date of filing: 30.06.1999

(51) International Patent Classification (IPC)7: A61P 19/00, A61P 19/02, C07K 14/47, C07K 16/18, C12N 15/12, C12N 15/62, C12Q 1/68, G01N 33/68 (86) International application number: PCT/US9914/829 (87) International publication number: WO 0000/161 (06.01.2000 Gazette 2000/01)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 30.06.1998 US 91318 P (71) Applicant: THE PROCTER & GAMBLE COMPANY Cincinnati,Ohio 45202 (US)	(72) Inventors: TINDAL, Michael, Howard Wyoming, OH 45215 (US) WANG, Richard, Lee West Chester, OH 45069 (US) (74) Representative: Clemo, Nicholas Graham et al Patent Department,Procter & Gamble Technical Centres Limited,Rusham Park,Whitehall Lane Egham, Surrey TW20 9NW Egham, Surrey TW20 9NW (GB)