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EP 4 061 385 A1

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(43) Date of publication: 28.09.2022 Bulletin 2022/39 (21) Application number: 19926735.2 (22) Date of filing: 18.12.2019

(51) International Patent Classification (IPC):  A61K 35/17(2015.01) C12N 15/09(2006.01) C12N 15/49(2006.01) C07K 14/54(2006.01) A61K 39/00(2006.01) C12N 15/24(2006.01) C12N 15/63(2006.01) C07K 16/28(2006.01) (52) Cooperative Patent Classification (CPC): A61K 35/17; C07K 16/2863; A61K 39/0011; A61K 2039/5156; C07K 16/283; C12N 2740/16043; C12N 5/0646; C12N 2510/00; C12N 2501/2312; C12N 2501/2318; C12N 2501/599; C07K 14/70535; C07K 14/7051; C07K 14/5434; C07K 14/70596; C07K 14/70517; C07K 14/70578; C07K 14/71; C07K 2319/00; C07K 2319/02; C07K 2319/03; C07K 2319/33 (86) International application number: PCT/TR2019/051103 (87) International publication number: WO 2021/101467 (27.05.2021 Gazette 2021/21)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: KH MA MD TN (30) Priority: 19.11.2019 TR 201918028 (71) Applicants: Acibadem Mehmet Ali Aydinlar Üniversitesi Atasehir/Istanbul (TR) Acibadem Labmed Saglik Hizmetleri Anonim Sirketi 34752 Atasehir/Istanbul (TR) Ovali, Ercüment 34758 Atasehir/Istanbul (TR)

(72) Inventors: OVALI, Ercüment 34758 Atasehir/Istanbul (TR) DILEK KANÇAGI, Derya 34752 Istanbul (TR) TASTAN, Cihan 34752 Istanbul (TR) (74) Representative: Yamankaradeniz, Kemal  Destek Patent, Inc. Maslak Mah., Büyükdere Cad., No: 243, Kat: 13, Spine Tower, Sariyer, 34485 Istanbul 34485 Istanbul (TR)