| (19) |
 |
|
(11) |
EP 0 000 650 A3 |
| (12) |
EUROPEAN PATENT APPLICATION |
| (88) |
Date of publication A3: |
|
04.04.1979 Bulletin 1979/07 |
| (43) |
Date of publication A2: |
|
07.02.1979 Bulletin 1979/03 |
| (22) |
Date of filing: 21.07.1978 |
|
|
| (84) |
Designated Contracting States: |
|
BE CH DE FR GB NL SE |
| (30) |
Priority: |
25.07.1977 US 818918
|
| (71) |
Applicant: Monsanto Company |
|
() |
|
| (72) |
Inventors: |
|
- Fields, Joseph Edward
()
- Slocombe, Robert Jackson
()
|
|
| |
|
| (54) |
Non-activating polyelectrolytes for separation of blood coagulation factors |
(57) The invention relates to polyelectrolytes and their use in the separation of blood
proteins.
Blood coagulation factors such as Factor VIII are separated from admixture with other
blood proteins without producing activation of said coagulation factor by contacting
with a water-insoluble, cross-linked polyelectrolyte copolymer of (a) C2-18unsaturated
monomer and (b) C4-12 unsaturated polycarboxylic acid or anhydride, in which 2-100%
of the carboxyl sites are substituted with amine-imides and substantially all the
free anhydrides are blocked with alkoxyalkylamine to form alkoxyalkylimide units.