(19)

(11)

EP 0 020 481 A1

(12)

(43) Date of publication: 07.01.1981 Bulletin 1981/01 (21) Application number: 79901311.0 (22) Date of filing: 17.09.1979

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) C07K 5/ 06( . ) A61K 38/ 04( . ) C07K 14/ 00( . ) (86) International application number: PCT/US1979/000752 (87) International publication number: WO 1980/000789 (01.05.1980 Gazette 1980/10)

(84) Designated Contracting States: CH DE FR GB NL SE (30) Priority: 23.10.1978 US 19780953516 23.05.1979 US 19790041679 (71) Applicant: ABBOTT LABORATORIES North Chicago, Illinois 60064 (US)	(72) Inventors: CHU, Daniel Tim-Wo Lake Villa, IL 60046 (US) MARTIN, Jerry Roy Waukegan, IL 60085 (US) THOMAS, Alford Mitchell Wadsworth, IL 60083 (US) WIDEBURG, Norman Earl Waukegan, IL 60085 (US) (74) Representative: de Haas, Michel, et al  Cabinet Beau de Loménie 55 rue d'Amsterdam F-75008 Paris F-75008 Paris (FR)