(19)

(11)

EP 0 039 349 A1

(12)

(43) Date of publication: 11.11.1981 Bulletin 1981/45 (21) Application number: 80902007.0 (22) Date of filing: 23.09.1980

(51) International Patent Classification (IPC):  A61K 35/ 16( . ) (86) International application number: PCT/US1980/001231 (87) International publication number: WO 1981/000813 (02.04.1981 Gazette 1981/08)

(84) Designated Contracting States: AT CH DE FR GB LI LU NL SE (30) Priority: 24.09.1979 US 19790077993 (71) Applicant: SCRIPPS CLINIC AND RESEARCH FOUNDATION La Jolla California 92037 (US)	(72) Inventor: KATZ, David H. La Jolla, CA 92037 (US)