(19)

(11)

EP 0 046 790 A1

(12)

(43) Date of publication: 10.03.1982 Bulletin 1982/10 (21) Application number: 81900705.0 (22) Date of filing: 23.02.1981

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 38/ 21( . ) A61K 51/ 00( . ) C07K 14/ 52( . ) C07K 14/ 575( . ) C07K 14/ 62( . ) C07K 16/ 00( . ) C12N 15/ 85( . ) C12P 21/ 00( . ) C12R 1/ 91( . ) A61K 38/ 00( . ) A61K 39/ 00( . ) C07K 14/ 00( . ) C07K 14/ 555( . ) C07K 14/ 61( . ) C07K 14/ 745( . ) C12N 5/ 10( . ) C12N 15/ 87( . ) C12P 21/ 02( . ) (86) International application number: PCT/US1981/000239 (87) International publication number: WO 1981/002425 (03.09.1981 Gazette 1981/21)

(84) Designated Contracting States: AT CH DE FR GB LI LU NL SE (30) Priority: 25.02.1980 US 19800124601 (71) Applicant: AXEL, Richard New York, NY 10025 (US)	(72) Inventor: AXEL, Richard New York, NY 10025 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 D-81634 München D-81634 München (DE)