(19)

(11)

EP 0 081 575 A1

(12)

(43) Date of publication: 22.06.1983 Bulletin 1983/25 (21) Application number: 82902304.0 (22) Date of filing: 17.06.1982

(51) International Patent Classification (IPC):  A61K 39/ 02( . ) (86) International application number: PCT/US1982/000816 (87) International publication number: WO 1983/000017 (06.01.1983 Gazette 1983/01)

(84) Designated Contracting States: DE FR GB NL SE (30) Priority: 22.06.1981 US 19810275446 (71) Applicant: UNIVERSITY OF ILLINOIS FOUNDATION Urbana, IL 61801 (US)	(72) Inventors: RISTIC, Miodrag Champaign, IL 61801 (US) LEVY, Michael G. Champaign, IL 61820 (US) (74) Representative: Ellis, John Clifford Holgate, et al  MEWBURN ELLIS & CO. 2/3 Cursitor Street London EC4A 1BQ London EC4A 1BQ (GB)