(19)

(11)

EP 0 084 052 A1

(12)

(43) Date of publication: 27.07.1983 Bulletin 1983/30 (21) Application number: 82902559.0 (22) Date of filing: 12.07.1982

(51) International Patent Classification (IPC):  A61K 9/ 107( . ) A61K 9/ 52( . ) A61K 9/ 127( . ) (86) International application number: PCT/US1982/000932 (87) International publication number: WO 1983/000294 (03.02.1983 Gazette 1983/04)

(84) Designated Contracting States: AT CH DE FR GB LI LU NL SE (30) Priority: 23.07.1981 US 19810286239 (71) Applicant: ARTHUR D. LITTLE, INC. Cambridge, Massachusetts 02140-2390 (US)	(72) Inventor: YESAIR, David W. Newbury, MA 01922 (US) (74) Representative: Warren, Anthony Robert, et al  BARON & WARREN, 18 South End, Kensington London W8 5BU London W8 5BU (GB)