(19)
(11) EP 0 090 972 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
01.08.1984 Bulletin 1984/31

(43) Date of publication A2:
12.10.1983 Bulletin 1983/41

(21) Application number: 83102602

(22) Date of filing: 16.03.1983
(84) Designated Contracting States:
BE CH DE FR GB IT LI NL

(30) Priority: 17.03.1982 JP 4068782
17.03.1982 JP 4068882
17.03.1982 JP 4068982
17.03.1982 JP 4069082
17.03.1982 JP 4069182
17.03.1982 JP 4069282
17.03.1982 JP 4068682

(71) Applicant: Asahi Kasei Kogyo Kabushiki Kaisha
 ()

(72) Inventors:
  • Ibuki, Tadayuki
     ()
  • Sugihara, Taisuke
     ()
  • Kawakubo, Hiromu
     ()
  • Sone, Takanori
     ()

   


(54) Indazole derivatives


(57) A compound of the formula (I):

wherein

W, and W2 each independently is a hydrogen atom or a

group wherein Y is a n-C1-6 alkvlene group or a n-C1-6 alkylene group having a C1-6 alkyl group substituent; and R, and R2 each independently is a hydrogen atom or a C1-5 alkyl group, and

group in

group may form a saturated heterocyclic ring selected from the group consisting of morphohno. pyrrolidino, piperidino, homopiperidino and piperazino groups. and the saturated heterocyclic ring except the morpholino group may have at least one C1-4 alkyl group, hydroxyl group or halogen atom as a substituent;

Z, is a hydrogen atom, a chlorine atom, a bromine atom, an iodine atom, a hydroxyl group, an amino group, a C1-3 alkyl group or a methoxy group;

Z2 is a hydrogen atom or an amino group;

when W, and W2 are both hydrogen atoms, Z, is a hydroxyl group or an iodine atom and Z2 is hydrogen atom, or Z, and 22 are both amino groups;

When Z, and 22 are both hydrogen atoms, the

group in either W, or W2 is a morpholino group;

when Z, is a chlorine atom, a hydroxyl group, an iodine atom, a methyl group or a methoxy group, Z2 is a hydrogen atom;

when Z, is an amino group, Z2 is a hydrogen atom or an amino group;

when Z, is a methyl group, a methoxy group or an amino group, Z, is in the 5-position; when Z, is an iodine atom, Z, is in the 5- or 7-position; and when Z, and Z2 are both amino groups. Z, and Z2 are in the 5- and 7-positions; and the physiologically acceptable acid addition salt thereof.







Search report