(57) Novel piperidine derivatives are disclosed having hypotensive activity, as well as
pharmaceutical preparations containing them. The novel compounds are of the formula
wherein A is a hydroxyl group, a halogen atom, a C,-C5 alkyl group, a C1-C5 alkoxy group, a C2-C5 alkenyloxy group, a C1-C5 alkinyloxy group, a C1-C5 alkylthio group, a carboxyl group, a C1-C5 alkoxycarbonyl group, a nitro group, an amino group, a C1-C5 alkylamino group, a C,-C5 alkanoylamino group, a sulfamoyl group, a mono- or di- (C1-C5 alkyl) aminosulfonyl group, a C1-C5 alkylsulfonyl group, a carbamoyl group, a cyano group or a trifluoromethyl group;
when m is 2 or more, A may be the same or different groups, or two A groups may combine
to form a C,-C5 alkylenedioxy group; m is 0 or an integer of 1-5; Q is a carbonyl group or a hydroxymethylene
group; R is a hydrogen atom or an alkyl group having 1-4 carbon atoms; X and Y are
defined as follows: i) when Y = H, X represents
ii) when Y = CH3, X represents
and when
X represents a hydrogen atom and their pharmacologically acceptable acid addition
salts.
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