(19)

(11)

EP 0 093 774 A1

(12)

(43) Date of publication: 16.11.1983 Bulletin 1983/46 (21) Application number: 83900139.0 (22) Date of filing: 17.11.1982

(51) International Patent Classification (IPC):  C07K 16/ 20( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1982/001618 (87) International publication number: WO 1983/001785 (26.05.1983 Gazette 1983/13)

(84) Designated Contracting States: AT BE CH DE FR GB LI LU NL SE (30) Priority: 17.11.1981 US 19810322241 (71) Applicant: BRIGHAM AND WOMEN'S HOSPITAL Boston, MA 02115 (US)	(72) Inventors: DAVID, John R. Jamaica Plain, MA 02130 (US) PRATT, Diane McMahon Roslindale, MA 02131 (US)