(19)

(11)

EP 0 101 731 A1

(12)

(43) Date of publication: 07.03.1984 Bulletin 1984/10 (21) Application number: 83901271.0 (22) Date of filing: 23.02.1983

(51) International Patent Classification (IPC):  A61K 39/ 15( . ) C07K 16/ 10( . ) (86) International application number: PCT/US1983/000235 (87) International publication number: WO 1983/002895 (01.09.1983 Gazette 1983/20)

(84) Designated Contracting States: AT CH DE FR GB LI NL SE (30) Priority: 23.02.1982 US 19820351643 (71) Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE Cambridge, MA 02138 (US)	(72) Inventor: FIELDS, Bernard N. West Newton, MA 02165 (US)