(19)
(11) EP 0 103 445 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
17.10.1984 Bulletin 1984/42

(43) Date of publication A2:
21.03.1984 Bulletin 1984/12

(21) Application number: 83305093

(22) Date of filing: 02.09.1983
(84) Designated Contracting States:
CH DE FR GB IT LI SE

(30) Priority: 03.09.1982 JP 15280982
21.09.1982 JP 16308282

(71) Applicant: TEIJIN LIMITED
 ()

(72) Inventors:
  • Noyori, Ryoji
     ()
  • Suzuki, Masaaki
     ()
  • Kurozumi, Seizi
     ()
  • Kawagishi, Toshio
     ()

   


(54) Process for production of prostaglandins E or F, and novel 7-(carbo- or thiocarbo-acyloxy) prostaglandins E or F


(57) A novel process for the production of prostaglandins E or F which comprises subjecting a 7-(thio-carboacyloxy)prostaglandin to selective deoxygenation reaction to split off the 7-(thioacyloxy) group, and thereafter, as required, subjecting the reaction product to reduction, deprotection and/or hydrolysis.
The present invention also provide a 7-(carboacyloxy or thiocarboacyloxy)prostaglandin E or F represented by the formula:

wherein

R1 represents H, C1-10 alkyl, or tri(C1-7 hydrocarbon)silyl,

R2 represents a C1-1 alkyl 5- or 6-membered cycloalkyl which may be substituted,

R5 represents H or CH3, each of R3 and R4 is H, OH or a protected hydroxyl, the symbol .... represents a single or double bond,

A represents

or

,

B represents -CH2CH2, -CH=CH- or -C≡C-, and

Z represents carboacyl or thiocarboacyl.





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