(19)

(11)

EP 0 103 636 A1

(12)

(43) Date of publication: 28.03.1984 Bulletin 1984/13 (21) Application number: 83901458.0 (22) Date of filing: 14.03.1983

(51) International Patent Classification (IPC):  A61K 9/ 00( . ) A61K 9/ 22( . ) C07D 307/ 77( . ) C07D 489/ 08( . ) A61K 9/ 20( . ) A61K 31/ 485( . ) C07D 489/ 00( . ) (86) International application number: PCT/US1983/000333 (87) International publication number: WO 1983/003197 (29.09.1983 Gazette 1983/23)

(84) Designated Contracting States: AT BE CH DE FR GB LI LU NL SE (30) Priority: 16.03.1982 US 19820358820 04.02.1983 US 19830464110 (71) Applicant: ROCKEFELLER UNIVERSITY New York, NY 10021 (US)	(72) Inventors: KREEK, Mary Jeanne New York, NY 10021 (US) FISHMAN, Jack New York, NY 10021 (US) (74) Representative: Weinhold, Peter, Dr.  Siegfriedstrasse 8 D-8000 München 40 D-8000 München 40 (DE)