| (19) |
 |
|
(11) |
EP 0 106 028 A3 |
| (12) |
EUROPEAN PATENT APPLICATION |
| (88) |
Date of publication A3: |
|
30.10.1985 Bulletin 1985/44 |
| (43) |
Date of publication A2: |
|
25.04.1984 Bulletin 1984/17 |
| (22) |
Date of filing: 08.07.1983 |
|
|
| (84) |
Designated Contracting States: |
|
BE CH DE FR GB IT LI LU NL SE |
| (30) |
Priority: |
14.10.1982 US 434302
|
| (71) |
Applicant: PENNWALT CORPORATION |
|
() |
|
| (72) |
Inventor: |
|
- Raghunathan, Yegnaswami
()
|
|
| |
|
| (54) |
Novel diuretic/antihypertensive compositions and methods of preparation |
(57) A combination tablet containing metolazone and triamterene is useful in diuretic
therapy and the treatment of hypertension. The composition is advantageous in the
prevention of hypokalemia, a common side effect of diuretic therapy and possesses
enhanced dissolution properties. Proper selection of the excipient formulation permits
preparation of the tablets by direct compression.