(19)

(11)

EP 0 111 560 A1

(12)

(43) Date of publication: 27.06.1984 Bulletin 1984/26 (21) Application number: 83902361.0 (22) Date of filing: 14.06.1983

(51) International Patent Classification (IPC):  A61K 9/ 22( . ) A61K 9/ 62( . ) A61K 9/ 50( . ) A61K 31/ 60( . ) (86) International application number: PCT/US1983/000928 (87) International publication number: WO 1984/000004 (05.01.1984 Gazette 1984/01)

(84) Designated Contracting States: AT BE CH DE FR GB LI LU NL SE (30) Priority: 14.06.1982 US 19820388183 (71) Applicant: Key Pharmaceuticals, Inc. Miami, Florida 33169 (US)	(72) Inventor: CHARLES, Hsiao Cooper City, FL 33328 (US) (74) Representative: Werner, Hans-Karsten, Dr., et al  Patentanwälte Von Kreisler-Selting-Werner Postfach 10 22 41 D-50462 Köln D-50462 Köln (DE)