(19)

(11)

EP 0 118 536 A1

(12)

(43) Date of publication: 19.09.1984 Bulletin 1984/38 (21) Application number: 83902974.0 (22) Date of filing: 07.09.1983

(51) International Patent Classification (IPC):  A61K 31/ 145( . ) A61K 31/ 195( . ) A61K 31/ 505( . ) A61K 31/ 165( . ) A61K 31/ 365( . ) A61K 31/ 60( . ) (86) International application number: PCT/US1983/001343 (87) International publication number: WO 1984/000887 (15.03.1984 Gazette 1984/07)

(84) Designated Contracting States: AT BE CH DE FR GB LI LU NL SE (30) Priority: 07.09.1982 US 19820415185 (71) Applicant: THE BETH ISRAEL HOSPITAL ASSOCIATION Boston, MA 02109 (US)	(72) Inventor: ALTSCHULE, Mark, D. Brookline, MA 02146 (US)