(19)

(11)

EP 0 119 209 A1

(12)

(43) Date of publication: 26.09.1984 Bulletin 1984/39 (21) Application number: 83902587.0 (22) Date of filing: 05.07.1983

(51) International Patent Classification (IPC):  C12Q 1/ 68( . ) (86) International application number: PCT/US1983/001029 (87) International publication number: WO 1984/001174 (29.03.1984 Gazette 1984/09)

(84) Designated Contracting States: AT BE CH DE FR GB LI LU NL SE (30) Priority: 20.09.1982 US 19820420129 (71) Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE Cambridge, MA 02138 (US)	(72) Inventors: WIRTH, Dyann, Fergus Cambridge, MA 02138 (US) MCMAHON-PRATT, Diane Portland, CT 06480 (US)