(19)

(11)

EP 0 122 267 A1

(12)

(43) Date of publication: 24.10.1984 Bulletin 1984/43 (21) Application number: 83903133.0 (22) Date of filing: 02.09.1983

(51) International Patent Classification (IPC):  A61K 35/ 14( . ) C07K 16/ 12( . ) A61M 1/ 28( . ) (86) International application number: PCT/US1983/001373 (87) International publication number: WO 1984/001505 (26.04.1984 Gazette 1984/11)

(84) Designated Contracting States: BE DE FR GB SE (30) Priority: 21.10.1982 US 19820435806 (71) Applicant: MINNEAPOLIS MEDICAL RESEARCH FOUNDATION INC. Minneapolis, MN 55415 (US)	(72) Inventors: KEANE, William, F. Edina, MN 55435 (US) PETERSON, Phillip, K. Minneapolis, MN 55410 (US) (74) Representative: MacGregor, Gordon, et al  ERIC POTTER CLARKSON St. Mary's Court St. Mary's Gate Nottingham, NG1 1LE Nottingham, NG1 1LE (GB)