ATBECHDEFRGBITLILUNLSE0122494EUROPEAN PATENT APPLICATIONA319861126EP8410303019840320830783119830322GB831043719830418GB1986112619864819841024198443 6C 07D 401/04 A 6C 07D 403:04 B 6C 07D 413:04 B 6C 07D 417:04 B 6A 61K 31:53 B 6C 07D 253:06 BenTriazine derivatives, processes for preparation thereof and pharmaceutical compositions comprising the samefrDérivés de triazine, leur procédé de préparation et les compositions pharmaceutiques les contenantsdeTriazin-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische ZusammensetzungenFUJISAWA PHARMACEUTICAL CO., LTD.Teraji, TsutomuShiokawa, YouichiOkumura, KazuoSato, YoshinariATBECHDEFRGBITLILUNLSE19861126198648

New triazine derivatives represented by the formula: wherein

R' is a 1, 2, 3, 4-tetrahydroauinolyl,
2-oxo-1, 2, 3, 4-tetrahydroquinolyl,
2-oxo-1, 2-dihydroquinolyl,
indolyl,
2-oxoindolinyl,
benzothiazolyl,
2-oxobenzothiazolinyl,
3,4-dihydro-1H-2, 1-benzothiazinyl in which the S atom optionally oxidized, or
3-oxo-2, 3-dihydro-4H-1, 4-benzoxazinyl, each of which may have one or more substituentis) selected from lower alkyl. hydroxy (lower) alkyl, lower alkylamino, lower alkanoyl, cyclic lower alkanoyl, lower alkoxy (lower) alkyl, lower alkylamino (lower) alkanoyl, benzyl, benryloxy (lower)-alkyl, lower alkoxycarbonyl (lower) alkyl and
4-(2-hydroxyethyl) piperazin-1-yl-carbonylmethyl;
R² is a hydrogen, lower alkenyl, benzyl, carboxy (lower)-alkyl or lower alkoxycarbonyl (lower) alkyl;
R³ and R⁴, which may be the same or different, are each hydrogen or lower alkyl or together represent a bond; provided that when R' is 2-oxo-1, 2,3, 4-tetrahydroquinolyl which is unsubstituted or substituted by a lower alkyl, then, R⁴ is a hydrogen or R² is a lower alkenyl, benzyl, carboxy (lower) alkyl or lower alkoxycarbonyl (lower) alkyl; and pharmaceutically acceptable salt thereof, which are useful in the treatment of hypertension, thrombosis and ulcer in human beings and animals.