(19)

(11)

EP 0 122 926 A1

(12)

(43) Date of publication: 31.10.1984 Bulletin 1984/44 (21) Application number: 83903269.0 (22) Date of filing: 16.09.1983

(51) International Patent Classification (IPC):  A61K 35/ 24( . ) A61K 38/ 00( . ) C07K 14/ 47( . ) A61K 35/ 28( . ) A61K 38/ 20( . ) (86) International application number: PCT/US1983/001439 (87) International publication number: WO 1984/001090 (29.03.1984 Gazette 1984/09)

(84) Designated Contracting States: AT BE CH DE FR GB LI LU NL SE (30) Priority: 20.09.1982 US 19820419995 25.08.1983 US 19830526356 (71) Applicant: ENDORPHIN, INC. Seattle Washington 98101 (US)

(72) Inventors: HOUCK, John, C. Seattle, WA 98199 (US) PATT, Leonard, M. Seattle, WA 98125 (US) (74) Representative: Weinhold, Peter, Dr.  Patentanwälte Dipl.-Ing. P. Wirth Dr. V. Schmied-Kowarzik Dipl.-Ing. G. Dannenberg Dr. P. Weinhold Dr. D. Gudel Dipl.-Ing. S. Schubert Siegfriedstr. Patentanwälte Dipl.-Ing. P. Wirth Dr. V. Schmied-Kowarzik Dipl.-Ing. G. Dannenberg Dr. P. Weinhold Dr. D. Gudel Dipl.-Ing. S. Schubert Siegfriedstr. (DE)