(19)

(11)

EP 0 126 119 A1

(12)

(43) Date of publication: 28.11.1984 Bulletin 1984/48 (21) Application number: 83903679.0 (22) Date of filing: 18.10.1983

(51) International Patent Classification (IPC):  A61K 39/ 018( . ) (86) International application number: PCT/US1983/001609 (87) International publication number: WO 1984/001716 (10.05.1984 Gazette 1984/12)

(84) Designated Contracting States: AT CH DE FR GB LI (30) Priority: 03.11.1982 US 19820438641 (71) Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURI Columbia Missouri 65201 (US)	(72) Inventors: BUENING, Gerald, Mathew Columbia, MO 65201 (US) CARSON, Charles, Andrew Columbia, MO 65201 (US)