| (19) |
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(11) |
EP 0 132 082 A3 |
| (12) |
EUROPEAN PATENT APPLICATION |
| (88) |
Date of publication A3: |
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23.10.1985 Bulletin 1985/43 |
| (43) |
Date of publication A2: |
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23.01.1985 Bulletin 1985/04 |
| (22) |
Date of filing: 04.07.1984 |
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| (84) |
Designated Contracting States: |
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AT BE CH DE FR GB IT LI LU NL SE |
| (30) |
Priority: |
08.07.1983 US 512088
|
| (71) |
Applicant: WARNER-LAMBERT COMPANY |
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() |
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| (72) |
Inventors: |
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- Bunge, Richard H.
()
- Hurley, Timothy R.
()
- Tunac, Josefino B.
()
- French, James C.
()
- Smitka, Tim A.
()
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| |
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| (54) |
Antibiotic/antitumor compounds and their production |
(57) A purified isolate of an actinomycete identified as ATCC 39363 is capable of producing
a complex of sulfur-containing antibiotic compounds having antitumor activity.
Antibiotic compounds CL-1577A and CL-1577B and their closely related congeners are
produced by cultivating isolate ATCC 39363 under aerobic conditions in a culture medium
containing assimilable sources of carbon and nitrogen until a substantial quantity
of the CL-1577 complex is produced, and subsequently isolating the complex or one
or more of the compounds.
The antibiotic compounds CL-1577A, CL-1577B, their congeners, and pharmaceutical compositions
comprising these substances together with a suitable carrier are also disclosed.