(19)

(11)

EP 0 133 437 A1

(12)

(43) Date of publication: 27.02.1985 Bulletin 1985/09 (21) Application number: 84900801.0 (22) Date of filing: 18.01.1984

(51) International Patent Classification (IPC):  A61K 31/ 07( . ) A61K 31/ 355( . ) A61K 33/ 30( . ) A61K 36/ 886( . ) A61K 31/ 315( . ) A61K 31/ 59( . ) A61K 36/ 185( . ) C07D 233/ 64( . ) (86) International application number: PCT/US1984/000080 (87) International publication number: WO 1984/002845 (02.08.1984 Gazette 1984/18)

(84) Designated Contracting States: AT BE CH DE FR GB LI LU NL SE (30) Priority: 21.01.1983 US 19830460007 (71) Applicant: ADVANCED DRUG TECHNOLOGY CORPORATION Indianapolis, IN 46260 (US)	(72) Inventor: BILTON, Gerald, L. Zionsville, IN 46077 (US)