(57) There are described compounds of formula I,
in which
Z is R2CH (COOH) NH- or R1SCH2-,
R1is hydrogen or R8CO-,
R8 is alkyl C1 to 10 or phenyl,
R is hydrogen, alkyl C1 to 6, or alkyl C1 to 6 substituted by phenyl, -NH2, -COOH or by alkyl C1 to 6 thio,
R2 is hydrogen, alkyl C1 to 10, cycloalkyl C3 to 10, phenyl, phenylalkyl C7 to 12, alkoxy
C1 to 6 - alkyl C1 to 6, alkyl C1 to 6 - thioalkyl C1 to 6, phenyloxyalkyl C7 to 12
or phenylthioalkyl C7 to 12,
R. and R5, which may be the same or different, are each hydrogen, alkyl C1 to 10, cycloalkyl
C3 to 10, phenylalkyl C7 to 12, or phenyl; the phenyl and phenylalkyl each optionally
being substituted by one or more alkyl C1 to 6, alkoxy C1 to 6 or halogen groups,
or
R. and R5 together form a - (CH2),,- or - (CW2)5- chain, and
R6 is hydrogen, alkyl C1 to 6 or phenylalkyl C7 to 12, and pharmaceutically acceptable
salts and esters thereof.
There are also described processes for making the compounds and their formulation
and use as pharmaceuticals, eg. angiotensin converting enzyme inhibitors.
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