(19)
(11) EP 0 146 370 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
23.04.1986 Bulletin 1986/17

(43) Date of publication A2:
26.06.1985 Bulletin 1985/26

(21) Application number: 84308764

(22) Date of filing: 14.12.1984
(84) Designated Contracting States:
AT BE CH DE FR IT LI LU NL SE

(30) Priority: 16.12.1983 GB 8333580
28.09.1984 GB 8424607

(71) Applicant: JOHN WYETH & BROTHER LIMITED
 ()

(72) Inventor:
  • Crossley, Roger
     ()

   


(54) Imidazoquinolines containing other heterocyclic groups


(57) @ The invention provides novel imidazoquinolines, processes for their preparation and pharmaceutical compositions containing them. The compounds have Formula I

wherein A is a C1-C4 straight or branched alkylene chain which may be saturated or unsaturated, B is a C2-C4 straight or branched alkylene chain which may be saturated or unsaturated, R' and R2 are the same or different and are hydrogen, alkyl, alkoxy, alkoxyalkyl, hydroxyalkyl, hydroxy, halogen, nitro, carboxy, carboxylic ester, carbamoyl, carbamoyloxy, cyano, acyl, acylamino or trifluoromethyl, Het is a heterocyclic group chosen from imidazolyl, imidazolinyl, benzimidazolyl, thiazolyl, thiazolinyl, quinolyl, piperidyl, pyridyl, benzothiazolyl and pyrimidyl, any of which heterocyclic groups may be substituted, and x is 0 or 1, and pharmaceutically acceptable salts thereof.
The compounds are anti-ulcer/anti-secretory agents.





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