(19)

(11)

EP 0 146 563 A1

(12)

(43) Date of publication: 03.07.1985 Bulletin 1985/27 (21) Application number: 84901866.0 (22) Date of filing: 13.04.1984

(51) International Patent Classification (IPC):  G01N 33/ 50( . ) C07K 14/ 005( . ) C07K 14/ 415( . ) C07K 16/ 00( . ) C12N 15/ 00( . ) C12Q 1/ 00( . ) G01N 33/ 53( . ) G01N 33/ 577( . ) A61K 39/ 00( . ) C07K 14/ 195( . ) C07K 14/ 575( . ) C07K 19/ 00( . ) C12N 15/ 02( . ) C12Q 1/ 70( . ) G01N 33/ 574( . ) G01N 33/ 76( . ) (86) International application number: PCT/US1984/000572 (87) International publication number: WO 1984/004598 (22.11.1984 Gazette 1984/27)

(84) Designated Contracting States: AT BE CH DE FR GB LI LU NL SE (30) Priority: 06.05.1983 US 19830492210 (71) Applicant: The Trustees of Columbia University in the City of New York New York, NY 10027 (US)	(72) Inventors: CANFIELD, Robert, E. New York, NY 10025 (US) ARMSTRONG, Elmo, G. Bronx, NY 10471 (US) EHRLICH, Paul, H. New York, NY 10032 (US) BIRKEN, Steven Dumont, NJ 07628 (US) (74) Representative: Henkel, Feiler, Hänzel & Partner  Möhlstrasse 37 D-81675 München D-81675 München (DE)