(19)

(11)

EP 0 153 403 A1

(12)

(43) Date of publication: 04.09.1985 Bulletin 1985/36 (21) Application number: 84903307.0 (22) Date of filing: 15.08.1984

(51) International Patent Classification (IPC):  A61K 51/ 04( . ) C07C 57/ 58( . ) (86) International application number: PCT/US1984/001320 (87) International publication number: WO 1985/000753 (28.02.1985 Gazette 1985/05)

(84) Designated Contracting States: AT BE CH DE FR GB LI NL SE (30) Priority: 17.08.1983 US 19830524173 06.08.1984 US 19840638431 (71) Applicant: MALLINCKRODT, INC.(a Missouri corporation) St. Louis Missouri 63134 (US)	(72) Inventors: WHITE, David, H. Florissant, MO 63031 (US) DEAN, Richard, T. Chesterfield, MO 63017 (US) (74) Representative: Eyles, Christopher Thomas  BATCHELLOR, KIRK & CO. 2 Pear Tree Court Farringdon Road London, EC1R 0DS London, EC1R 0DS (GB)