(19)
(11) EP 0 156 331 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
20.08.1986 Bulletin 1986/34

(43) Date of publication A2:
02.10.1985 Bulletin 1985/40

(21) Application number: 85103436

(22) Date of filing: 22.03.1985
(84) Designated Contracting States:
AT BE CH DE FR GB IT LI NL SE

(30) Priority: 27.03.1984 JP 6039984

(71) Applicant: KAKEN PHARMACEUTICAL CO., LTD.
 ()

(72) Inventors:
  • Nakano, Jun
     ()
  • Nagahara, Michiko
     ()
  • Hayashida, Mitsuo
     ()
  • Suzuki, Yuji
     ()
  • Maruyama, Yohichi
     ()
  • Hori, Toshimitsu
     ()
  • Sakai, Akira
     ()

   


(54) Benzuforan derivatives, processes for preparing the same and antihypertensive agents containing the same


(57) A [2-hydroxy-3-(4-phenylpiperazinyl)propoxy) benzofuran derivative having the formula (I):

wherein X is acetyl, carbamoyl, cyano, a lower alkoxycarbonyl, carboxyl or 1-hydroxyethyl group, R is hydrogen atom, a lower alkoxy group, a lower alkyl group or a halogen atom;. R is attached to an arbitrary position of ortho-position, meta-position and para-position to N-phenyl group, and a group having the formula:

is attached to an arbitrary position of 4, 5, 6 and 7 positions to benzofuran ring orthe salt thereof, a process for preparing the same and an antihypertensive agent containing the same as an effective component. The benzofuran derivative has a strong a-adrenergic blockade effect and calcium antagonistic effect with a more decreased side-effect.





Search report