(19)

(11)

EP 0 158 642 A1

(12)

(43) Date of publication: 23.10.1985 Bulletin 1985/43 (21) Application number: 84903224.0 (22) Date of filing: 13.08.1984

(51) International Patent Classification (IPC):  C12M 3/ 00( . ) C12N 13/ 00( . ) C12N 1/ 02( . ) H01L 31/ 18( . ) (86) International application number: PCT/US1984/001263 (87) International publication number: WO 1985/001514 (11.04.1985 Gazette 1985/09)

(84) Designated Contracting States: AT BE CH DE FR GB LI LU NL SE (30) Priority: 26.09.1983 US 19830535779 (71) Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION Iowa City, Iowa 52242 (US)	(72) Inventors: RHEAD, William, J. Iowa City, IA 52242 (US) FRITCHMAN, Kathie, S. Solon, IA 52333 (US) STOUT, Ferris, M. Roosevelt, NJ 08555 (US) MELTON, Hewlett Pleasanton, CA 94566 (US)